دورية أكاديمية
Damage dynamics and the role of chance in the timing of E. coli cell death.
| العنوان: | Damage dynamics and the role of chance in the timing of E. coli cell death. |
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| المؤلفون: | Yang Y; Department of molecular Cell biology, Weizmann Institute of Science, 71600, Rehovot, Israel. yifan.yang@weizmann.ac.il.; Université de Paris - INSERM Unit 1284, Center for Research and Interdisciplinarity (CRI), Paris, F-75004, France. yifan.yang@weizmann.ac.il., Karin O; Department of molecular Cell biology, Weizmann Institute of Science, 71600, Rehovot, Israel., Mayo A; Department of molecular Cell biology, Weizmann Institute of Science, 71600, Rehovot, Israel., Song X; Université de Paris - INSERM Unit 1284, Center for Research and Interdisciplinarity (CRI), Paris, F-75004, France., Chen P; Université de Paris - INSERM Unit 1284, Center for Research and Interdisciplinarity (CRI), Paris, F-75004, France.; National Center for Nanoscience and Technology, 100190, Beijing, China., Santos AL; Université de Paris - INSERM Unit 1284, Center for Research and Interdisciplinarity (CRI), Paris, F-75004, France.; Department of Chemistry, Rice University, Houston, TX, 77005, USA., Lindner AB; Université de Paris - INSERM Unit 1284, Center for Research and Interdisciplinarity (CRI), Paris, F-75004, France., Alon U; Department of molecular Cell biology, Weizmann Institute of Science, 71600, Rehovot, Israel. uri.alon@weizmann.ac.il. |
| المصدر: | Nature communications [Nat Commun] 2023 Apr 18; Vol. 14 (1), pp. 2209. Date of Electronic Publication: 2023 Apr 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Escherichia coli*/metabolism, Cell Division ; Cell Death ; Stochastic Processes |
| مستخلص: | Genetically identical cells in the same stressful condition die at different times. The origin of this stochasticity is unclear; it may arise from different initial conditions that affect the time of demise, or from a stochastic damage accumulation mechanism that erases the initial conditions and instead amplifies noise to generate different lifespans. To address this requires measuring damage dynamics in individual cells over the lifespan, but this has rarely been achieved. Here, we used a microfluidic device to measure membrane damage in 635 carbon-starved Escherichia coli cells at high temporal resolution. We find that initial conditions of damage, size or cell-cycle phase do not explain most of the lifespan variation. Instead, the data points to a stochastic mechanism in which noise is amplified by a rising production of damage that saturates its own removal. Surprisingly, the relative variation in damage drops with age: cells become more similar to each other in terms of relative damage, indicating increasing determinism with age. Thus, chance erases initial conditions and then gives way to increasingly deterministic dynamics that dominate the lifespan distribution. (© 2023. The Author(s).) |
| References: | Trends Microbiol. 2020 Apr;28(4):304-314. (PMID: 31952908) Nat Commun. 2019 Dec 2;10(1):5495. (PMID: 31792199) Nat Rev Microbiol. 2021 Feb;19(2):123-132. (PMID: 33024310) Annu Rev Microbiol. 2004;58:161-81. (PMID: 15487934) Science. 2020 Jul 17;369(6501):325-329. (PMID: 32675375) Annu Rev Biochem. 2015;84:435-64. (PMID: 25784053) Science. 1960 Jul 1;132(3418):14-21. (PMID: 13835176) Cell Syst. 2019 Jul 24;9(1):64-73.e3. (PMID: 31326371) Nature. 2021 Dec;600(7888):290-294. (PMID: 34789881) Cell. 2008 Nov 14;135(4):679-90. (PMID: 19013277) Aging Cell. 2021 Mar;20(3):e13314. (PMID: 33559235) Geroscience. 2021 Feb;43(1):329-341. (PMID: 33236264) J Biochem. 2009 Oct;146(4):449-54. (PMID: 19454621) Mol Microbiol. 2007 Oct;66(1):100-9. (PMID: 17725563) Curr Biol. 2010 Jun 22;20(12):1099-103. (PMID: 20537537) PLoS Comput Biol. 2022 Sep 30;18(9):e1010415. (PMID: 36178967) PLoS Biol. 2010 Aug 10;8(8):e1000450. (PMID: 20711477) Annu Rev Microbiol. 2011;65:189-213. (PMID: 21639793) Sci Adv. 2019 May 29;5(5):eaaw2069. (PMID: 31149637) Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3076-81. (PMID: 18287048) Elife. 2019 Sep 13;8:. (PMID: 31518229) Cell Syst. 2016 Oct 26;3(4):333-345.e4. (PMID: 27720632) J Bacteriol. 2000 Oct;182(19):5551-5. (PMID: 10986260) Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Feb;89(2):022811. (PMID: 25353538) Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14914-9. (PMID: 19706382) J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):722-7. (PMID: 17634318) Mech Ageing Dev. 2005 Mar;126(3):439-43. (PMID: 15664632) Nat Genet. 2005 Aug;37(8):894-8. (PMID: 16041374) Nature. 2014 Jan 9;505(7482):169-73. (PMID: 24317695) Nat Commun. 2021 Apr 19;12(1):2321. (PMID: 33875652) PLoS Biol. 2019 May 23;17(5):e3000266. (PMID: 31120870) Nature. 2016 Feb 4;530(7588):103-7. (PMID: 26814965) Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2654-E2661. (PMID: 28292901) J Biol Chem. 2014 May 2;289(18):12356-64. (PMID: 24634211) J Bacteriol. 2016 Dec 13;199(1):. (PMID: 27795327) FEMS Microbiol Rev. 2020 Jan 1;44(1):54-72. (PMID: 31633151) |
| تواريخ الأحداث: | Date Created: 20230418 Date Completed: 20230420 Latest Revision: 20231119 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10113371 |
| DOI: | 10.1038/s41467-023-37930-x |
| PMID: | 37072447 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-37930-x |