دورية أكاديمية
أعرض في EDS

Research article network analysis of polymicrobial chronic wound infections in Masanga, Sierra Leone.

التفاصيل البيبلوغرافية
العنوان: Research article network analysis of polymicrobial chronic wound infections in Masanga, Sierra Leone.
المؤلفون: Sandmann S; Institute of Medical Informatics, University of Münster, Münster, Germany., Nunes JV; Masanga Medical Research Unit (MMRU), Masanga, Sierra Leone.; Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Grobusch MP; Masanga Medical Research Unit (MMRU), Masanga, Sierra Leone.; Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Sesay M; Masanga Medical Research Unit (MMRU), Masanga, Sierra Leone., Kriegel MA; Section of Rheumatology and Clinical Immunology, Department of Medicine, University Hospital Münster, Münster, Germany.; Department of Translational Rheumatology and Immunology, Institute of Musculoskeletal Medicine, University of Münster, Münster, Germany.; Cells in Motion Interfaculty Centre, University of Münster, Münster, Germany.; Department of Immunobiology, Yale University School of Medicine, New Haven, USA., Varghese J; Institute of Medical Informatics, University of Münster, Münster, Germany., Schaumburg F; Institute of Medical Microbiology, University of Münster, Münster, Germany. frieder.schaumburg@ukmuenster.de.
المصدر: BMC infectious diseases [BMC Infect Dis] 2023 Apr 18; Vol. 23 (1), pp. 250. Date of Electronic Publication: 2023 Apr 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Coinfection*/epidemiology , Coinfection*/microbiology , Staphylococcal Infections*/microbiology , Wound Infection*/epidemiology , Wound Infection*/microbiology, Humans ; Staphylococcus aureus ; Sierra Leone/epidemiology ; Bacteria ; Klebsiella pneumoniae ; Pseudomonas aeruginosa
مستخلص: Background: Chronic wounds are frequently colonized or infected with multiple bacterial or fungal species, which can both promote or inhibit each other. Network analyses are helpful to understand the interplay of these species in polymicrobial infections. Our aim was to analyse the network of bacterial and fungal species in chronic wounds.
Methods: Swabs (n = 163) from chronic wound infections (Masanga, Sierra Leone, 2019-2020) were screened for bacterial and fungal species using non-selective agars. Some of these wounds were suspected but not confirmed Buruli ulcer. Species identification was done with MALDI-TOF mass spectrometry. Network analysis was performed to investigate co-occurrence of different species within one patient. All species with n ≥ 10 isolates were taken into account.
Results: Of the 163 patients, 156 had a positive wound culture (median of three different species per patient; range 1-7). Pseudomonas aeruginosa (n = 75) was the dominating species with frequent co-detections of Klebsiella pneumoniae (21 cases; OR = 1.36, 95%CI: 0.63-2.96, p = 0.47), Staphylococcus aureus (14 cases; OR = 1.06, 95%CI: 0.44-2.55, p = 1) and Proteus mirabilis (13 cases; OR = 0.84, 95%CI: 0.35-1.99, p = 0.69).
Conclusion: The culturome of chronic wounds in Sierra Leonean patients is highly diverse and characterized by the co-occurrence of P. aeruginosa, K. pneumoniae and S. aureus.
(© 2023. The Author(s).)
التعليقات: Erratum in: BMC Infect Dis. 2023 May 25;23(1):357. (PMID: 37231329)
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معلومات مُعتمدة: UL1 TR001863 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Africa; Community networks; Microbiome; Panton-Valentine leukocidin; Staphylococcus aureus, Pseudomonas aeruginosa; Wound infection
تواريخ الأحداث: Date Created: 20230418 Date Completed: 20230420 Latest Revision: 20240310
رمز التحديث: 20240310
مُعرف محوري في PubMed: PMC10112320
DOI: 10.1186/s12879-023-08204-0
PMID: 37072717
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-023-08204-0