دورية أكاديمية
أعرض في EDS

Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice.

التفاصيل البيبلوغرافية
العنوان: Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice.
المؤلفون: Schweizer RM; Division of Biological Sciences, University of Montana, Missoula, Montana, USA., Ivy CM; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Natarajan C; School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA., Scott GR; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Storz JF; School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA., Cheviron ZA; Division of Biological Sciences, University of Montana, Missoula, Montana, USA.
المصدر: Molecular ecology [Mol Ecol] 2023 Jul; Vol. 32 (13), pp. 3483-3496. Date of Electronic Publication: 2023 Apr 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Blackwell Scientific Publications, c1992-
مواضيع طبية MeSH: Peromyscus*/genetics , Hypoxia*/metabolism, Animals ; Respiration ; Adaptation, Physiological/genetics ; Altitude
مستخلص: Phenotypic plasticity can play an important role in the ability of animals to tolerate environmental stress, but the nature and magnitude of plastic responses are often specific to the developmental timing of exposure. Here, we examine changes in gene expression in the diaphragm of highland deer mice (Peromyscus maniculatus) in response to hypoxia exposure at different stages of development. In highland deer mice, developmental plasticity in diaphragm function may mediate changes in several respiratory traits that influence aerobic metabolism and performance under hypoxia. We generated RNAseq data from diaphragm tissue of adult deer mice exposed to (1) life-long hypoxia (before conception to adulthood), (2) post-natal hypoxia (birth to adulthood), (3) adult hypoxia (6-8 weeks only during adulthood) or (4) normoxia. We found five suites of co-regulated genes that are differentially expressed in response to hypoxia, but the patterns of differential expression depend on the developmental timing of exposure. We also identified four transcriptional modules that are associated with important respiratory traits. Many of the genes in these transcriptional modules bear signatures of altitude-related selection, providing an indirect line of evidence that observed changes in gene expression may be adaptive in hypoxic environments. Our results demonstrate the importance of developmental stage in determining the phenotypic response to environmental stressors.
(© 2023 John Wiley & Sons Ltd.)
References: Nat Genet. 2010 Oct;42(10):851-8. (PMID: 20818383)
Respir Physiol Neurobiol. 2017 Jan;235:95-103. (PMID: 27989891)
Exp Hematol. 2011 Nov;39(11):1090-100. (PMID: 21782766)
Nucleic Acids Res. 2019 Jul 2;47(W1):W191-W198. (PMID: 31066453)
Respir Physiol Neurobiol. 2005 Nov 15;149(1-3):287-99. (PMID: 16203217)
Proc Natl Acad Sci U S A. 1984 Sep;81(17):5484-8. (PMID: 6591201)
J Exp Biol. 2020 Mar 11;223(Pt 5):. (PMID: 32054682)
Evolution. 1999 Aug;53(4):1280-1287. (PMID: 28565539)
Proc Biol Sci. 2020 May 27;287(1927):20192750. (PMID: 32429808)
BMC Bioinformatics. 2008 Dec 29;9:559. (PMID: 19114008)
Genome Res. 2021 Jun 8;:. (PMID: 34103331)
Respir Physiol Neurobiol. 2005 Feb 15;145(2-3):235-42. (PMID: 15705538)
Am J Hum Genet. 2007 May;80(5):988-93. (PMID: 17436254)
Front Physiol. 2021 Aug 11;12:718163. (PMID: 34456754)
J Cell Biol. 2006 Nov 6;175(3):383-8. (PMID: 17074887)
Annu Rev Anim Biosci. 2021 Feb 16;9:149-171. (PMID: 33228375)
Am J Physiol. 1999 Sep;277(3):L645-52. (PMID: 10484473)
Eur J Neurosci. 2007 Nov;26(10):2865-72. (PMID: 18001283)
Bioinformatics. 2014 Apr 1;30(7):923-30. (PMID: 24227677)
Science. 2010 Jul 2;329(5987):75-8. (PMID: 20595611)
J Exp Biol. 2017 Oct 15;220(Pt 20):3616-3620. (PMID: 28839010)
Respir Physiol Neurobiol. 2019 Jun;264:40-50. (PMID: 30999061)
Evolution. 2014 Jan;68(1):48-62. (PMID: 24102503)
Biochem Biophys Res Commun. 2009 Dec 18;390(3):451-7. (PMID: 19785986)
Bioinformatics. 2014 Aug 1;30(15):2114-20. (PMID: 24695404)
J Exp Biol. 2013 Apr 1;216(Pt 7):1160-6. (PMID: 23197099)
Ann Hum Genet. 2021 Mar;85(2):58-72. (PMID: 33026655)
Arch Biochem Biophys. 2003 Jun 1;414(1):91-100. (PMID: 12745259)
Annu Rev Ecol Evol Syst. 2019 Nov;50:503-526. (PMID: 33033467)
Comp Biochem Physiol A Mol Integr Physiol. 2015 Aug;186:66-74. (PMID: 25446936)
Curr Opin Cell Biol. 2020 Apr;63:57-67. (PMID: 31972475)
Proc Biol Sci. 2019 Jul 24;286(1907):20190841. (PMID: 31337307)
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8635-40. (PMID: 22586089)
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13698-703. (PMID: 14581612)
Neuropsychopharmacology. 2016 Feb;41(3):802-10. (PMID: 26171716)
Dev Cell. 2004 Dec;7(6):843-54. (PMID: 15572127)
J Mammal. 2019 May 23;100(3):910-922. (PMID: 31138949)
Nat Commun. 2021 Oct 26;12(1):6195. (PMID: 34702827)
Dev Cell. 2019 Oct 7;51(1):89-98.e4. (PMID: 31474563)
Bioinformatics. 2010 Jan 1;26(1):139-40. (PMID: 19910308)
Am J Med Genet A. 2019 Jul;179(7):1376-1382. (PMID: 31069960)
Mitochondrion. 2015 Sep;24:105-12. (PMID: 26235939)
Mol Biol Evol. 2021 Sep 27;38(10):4286-4300. (PMID: 34037784)
PLoS Genet. 2019 Nov 7;15(11):e1008420. (PMID: 31697676)
J Exp Biol. 2021 Jan 7;224(Pt 1):. (PMID: 33268530)
Acta Physiol (Oxf). 2017 Dec;221(4):266-282. (PMID: 28640969)
F1000Prime Rep. 2015 Mar 03;7:26. (PMID: 25926977)
J Appl Physiol (1985). 1991 Mar;70(3):1146-51. (PMID: 2032980)
Respir Physiol. 1968 Sep;5(2):269-78. (PMID: 5693199)
Mol Biol Evol. 2020 Aug 1;37(8):2309-2321. (PMID: 32243546)
PLoS One. 2013 Dec 30;8(12):e85157. (PMID: 24386461)
Am J Physiol Regul Integr Comp Physiol. 2015 May 1;308(9):R779-91. (PMID: 25695288)
J Physiol. 2000 Apr 15;524 Pt 2:525-37. (PMID: 10766931)
Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R421-7. (PMID: 19494172)
معلومات مُعتمدة: R01 HL159061 United States HL NHLBI NIH HHS; R15 HD103925 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: Peromyscus; RNAseq; high-altitude adaptation; hypoxia; phenotypic plasticity
تواريخ الأحداث: Date Created: 20230419 Date Completed: 20230628 Latest Revision: 20240702
رمز التحديث: 20240702
مُعرف محوري في PubMed: PMC10330314
DOI: 10.1111/mec.16953
PMID: 37073620
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-294X
DOI:10.1111/mec.16953