دورية أكاديمية
Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice.
العنوان: | Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice. |
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المؤلفون: | Schweizer RM; Division of Biological Sciences, University of Montana, Missoula, Montana, USA., Ivy CM; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Natarajan C; School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA., Scott GR; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Storz JF; School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA., Cheviron ZA; Division of Biological Sciences, University of Montana, Missoula, Montana, USA. |
المصدر: | Molecular ecology [Mol Ecol] 2023 Jul; Vol. 32 (13), pp. 3483-3496. Date of Electronic Publication: 2023 Apr 19. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford, UK : Blackwell Scientific Publications, c1992- |
مواضيع طبية MeSH: | Peromyscus*/genetics , Hypoxia*/metabolism, Animals ; Respiration ; Adaptation, Physiological/genetics ; Altitude |
مستخلص: | Phenotypic plasticity can play an important role in the ability of animals to tolerate environmental stress, but the nature and magnitude of plastic responses are often specific to the developmental timing of exposure. Here, we examine changes in gene expression in the diaphragm of highland deer mice (Peromyscus maniculatus) in response to hypoxia exposure at different stages of development. In highland deer mice, developmental plasticity in diaphragm function may mediate changes in several respiratory traits that influence aerobic metabolism and performance under hypoxia. We generated RNAseq data from diaphragm tissue of adult deer mice exposed to (1) life-long hypoxia (before conception to adulthood), (2) post-natal hypoxia (birth to adulthood), (3) adult hypoxia (6-8 weeks only during adulthood) or (4) normoxia. We found five suites of co-regulated genes that are differentially expressed in response to hypoxia, but the patterns of differential expression depend on the developmental timing of exposure. We also identified four transcriptional modules that are associated with important respiratory traits. Many of the genes in these transcriptional modules bear signatures of altitude-related selection, providing an indirect line of evidence that observed changes in gene expression may be adaptive in hypoxic environments. Our results demonstrate the importance of developmental stage in determining the phenotypic response to environmental stressors. (© 2023 John Wiley & Sons Ltd.) |
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معلومات مُعتمدة: | R01 HL159061 United States HL NHLBI NIH HHS; R15 HD103925 United States HD NICHD NIH HHS |
فهرسة مساهمة: | Keywords: Peromyscus; RNAseq; high-altitude adaptation; hypoxia; phenotypic plasticity |
تواريخ الأحداث: | Date Created: 20230419 Date Completed: 20230628 Latest Revision: 20240702 |
رمز التحديث: | 20240702 |
مُعرف محوري في PubMed: | PMC10330314 |
DOI: | 10.1111/mec.16953 |
PMID: | 37073620 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1365-294X |
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DOI: | 10.1111/mec.16953 |