دورية أكاديمية
Alternate-day fasting induces metabolic and morphofunctional changes in the gastrointestinal tract of male rats.
| العنوان: | Alternate-day fasting induces metabolic and morphofunctional changes in the gastrointestinal tract of male rats. |
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| المؤلفون: | Beckmann APS; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, MT, Brasil., Gama LA; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, MT, Brasil., Machado MPR; Instituto de Biociências, Universidade Estadual Paulista, Botucatu, SP, Brasil.; Centro Universitário do Vale do Araguaia (UNIVAR), Barra do Garças, MT, Brasil., Alves WDL; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, MT, Brasil., Corá LA; Núcleo de Ciências Biológicas e Integradoras, NUCIB, Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brasil., Américo MF; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, MT, Brasil. |
| المصدر: | Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2023 Jul 01; Vol. 48 (7), pp. 535-543. Date of Electronic Publication: 2023 Apr 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 101264333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1715-5320 (Electronic) Linking ISSN: 17155312 NLM ISO Abbreviation: Appl Physiol Nutr Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Ottawa, ON : Canadian Science Publishing Original Publication: Ottawa, ON : National Research Council of Canada, c2006- |
| مواضيع طبية MeSH: | Gastrointestinal Tract* , Fasting*, Rats ; Male ; Animals ; Rats, Wistar ; Gastric Emptying ; Cholesterol ; Gastrointestinal Transit |
| مستخلص: | Alternate-day fasting (ADF) is a nutritional intervention with modulatory and overall protective effects, but its role in the gastrointestinal (GI) tract is still uncertain. The aim of this study was to investigate the influence of ADF on the metabolic patterns and morphofunctional motility of the GI tract in rats. Thirty-two male Wistar rats were allocated into groups: control for 15 days (CON 15, n = 8), control for 30 days (CON 30, n = 8), ADF for 15 days (ADF 15, n = 8), and ADF for 30 days (ADF 30, n = 8). Blood glucose, body weight, and food and water consumption were measured. Frequency and amplitude of gastric contractions as well as gastric emptying time, small intestinal transit time, and cecum arrival time were measured. Intestinal histomorphometric, relative weight of organs, lipidogram, and leptin levels were also evaluated. ADF decreased water consumption and food consumption. The weight gain decreased; however, the relative kidney weight increased. ADF triggered an increase in the amplitude of gastric contractions and accelerated gastric emptying. However, small intestinal transit time was delayed in both ADF groups. Total cholesterol, triglycerides, non-HDL cholesterol, and very low-density lipoprotein cholesterol levels decreased, whereas villus height, depth of the crypts and thickness of the circular, and longitudinal muscular layers of intestine increased after ADF. In conclusion, our results showed ADF exert an effect on both metabolism and GI motility and impacts on overall digestive functions. Competing Interests: The authors declare there are no competing interests. |
| فهرسة مساهمة: | Keywords: alternating current biosusceptometry; gastrointestinal transit; intermittent fasting; intestinal morphology; metabolic response |
| المشرفين على المادة: | 97C5T2UQ7J (Cholesterol) |
| تواريخ الأحداث: | Date Created: 20230419 Date Completed: 20230703 Latest Revision: 20230703 |
| رمز التحديث: | 20230703 |
| DOI: | 10.1139/apnm-2022-0356 |
| PMID: | 37073865 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1715-5320 |
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| DOI: | 10.1139/apnm-2022-0356 |