دورية أكاديمية
أعرض في EDS

Colonization and transmission of Staphylococcus aureus in schools: a citizen science project.

التفاصيل البيبلوغرافية
العنوان: Colonization and transmission of Staphylococcus aureus in schools: a citizen science project.
المؤلفون: van Tonder AJ; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., McCullagh F; Cottenham Village College, Cottenham, UK., McKeand H; Cottenham Village College, Cottenham, UK., Thaw S; St Bede's Inter-Church School, Cambridge, UK., Bellis K; Wellcome Sanger Institute, Hinxton, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Raisen C; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Lay L; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Aggarwal D; Wellcome Sanger Institute, Hinxton, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Holmes M; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Parkhill J; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Harrison EM; Wellcome Sanger Institute, Hinxton, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Kucharski A; Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK., Conlan A; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
المصدر: Microbial genomics [Microb Genom] 2023 Apr; Vol. 9 (4).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Microbiology Society Country of Publication: England NLM ID: 101671820 Publication Model: Print Cited Medium: Internet ISSN: 2057-5858 (Electronic) Linking ISSN: 20575858 NLM ISO Abbreviation: Microb Genom Subsets: MEDLINE
أسماء مطبوعة: Publication: Oct. 2015- : [London] : Microbiology Society
Original Publication: [London] : Society for General Microbiology, [2015]-
مواضيع طبية MeSH: Citizen Science* , Staphylococcal Infections*/microbiology, Child ; Humans ; Staphylococcus aureus/genetics ; Schools ; England
مستخلص: Aggregation of children in schools has been established to be a key driver of transmission of infectious diseases. Mathematical models of transmission used to predict the impact of control measures, such as vaccination and testing, commonly depend on self-reported contact data. However, the link between self-reported social contacts and pathogen transmission has not been well described. To address this, we used Staphylococcus aureus as a model organism to track transmission within two secondary schools in England and test for associations between self-reported social contacts, test positivity and the bacterial strain collected from the same students. Students filled out a social contact survey and their S. aureus colonization status was ascertained through self-administered swabs from which isolates were sequenced. Isolates from the local community were also sequenced to assess the representativeness of school isolates. A low frequency of genome-linked transmission precluded a formal analysis of links between genomic and social networks, suggesting that S. aureus transmission within schools is too rare to make it a viable tool for this purpose. Whilst we found no evidence that schools are an important route of transmission, increased colonization rates found within schools imply that school-age children may be an important source of community transmission.
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معلومات مُعتمدة: MR/S00291X/1 United Kingdom MRC_ Medical Research Council; 211864/Z/18/Z United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: MRSA; WGS; schools; social network analysis; transmission
تواريخ الأحداث: Date Created: 20230419 Date Completed: 20230421 Latest Revision: 20240313
رمز التحديث: 20240313
مُعرف محوري في PubMed: PMC10210949
DOI: 10.1099/mgen.0.000993
PMID: 37074324
قاعدة البيانات: MEDLINE
الوصف
تدمد:2057-5858
DOI:10.1099/mgen.0.000993