دورية أكاديمية
Etiology, Presentation, and Risk Factors for Diarrheal Syndromes in 3 Sub-Saharan African Countries After the Introduction of Rotavirus Vaccines From the Vaccine Impact on Diarrhea in Africa (VIDA) Study.
| العنوان: | Etiology, Presentation, and Risk Factors for Diarrheal Syndromes in 3 Sub-Saharan African Countries After the Introduction of Rotavirus Vaccines From the Vaccine Impact on Diarrhea in Africa (VIDA) Study. |
|---|---|
| المؤلفون: | Buchwald AG; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA., Verani JR; Division of Global Health Protection, Centers for Disease Control and Prevention, Nairobi, Kenya., Keita AM; Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, Mali., Jahangir Hossain M; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia., Roose A; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sow SO; Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, Mali., Omore R; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya., Doh S; Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, Mali., Jones JCM; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia., Nasrin D; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA., Zaman SMA; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia., Okoi C; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia., Antonio M; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia., Ochieng JB; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya., Juma J; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya., Onwuchekwa U; Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, Mali., Powell H; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA., Platts-Mills JA; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA., Tennant SM; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Kotloff KL; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Apr 19; Vol. 76 (76 Suppl 1), pp. S12-S22. |
| نوع المنشور: | Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Rotavirus Vaccines* , Cryptosporidiosis*/complications , Cryptosporidium* , Dysentery*/complications, Infant ; Child ; Humans ; Child, Preschool ; Case-Control Studies ; Diarrhea/epidemiology ; Diarrhea/prevention & control ; Diarrhea/etiology ; Risk Factors ; Kenya/epidemiology ; Anti-Bacterial Agents |
| مستخلص: | Background: Diarrheal disease is heterogeneous, including watery diarrhea (WD) and dysentery, some cases of which become persistent diarrhea (PD). Changes in risk over time necessitate updated knowledge of these syndromes in sub-Saharan Africa. Methods: The Vaccine Impact on Diarrhea in Africa (VIDA) study was an age-stratified, case-control study of moderate-to-severe diarrhea among children <5 years old in The Gambia, Mali, and Kenya (2015-2018). We analyzed cases with follow-up of about 60 days after enrollment to detect PD (lasting ≥14 days), examined the features of WD and dysentery, and examined determinants for progression to and sequelae from PD. Data were compared with those from the Global Enteric Multicenter Study (GEMS) to detect temporal changes. Etiology was assessed from stool samples using pathogen attributable fractions (AFs), and predictors were assessed using χ2 tests or multivariate regression, where appropriate. Results: Among 4606 children with moderate-to-severe diarrhea, 3895 (84.6%) had WD and 711 (15.4%) had dysentery. PD was more frequent among infants (11.3%) than in children 12-23 months (9.9%) or 24-59 months (7.3%), P = .001 and higher in Kenya (15.5%) than in The Gambia (9.3%) or Mali (4.3%), P < .001; the frequencies were similar among children with WD (9.7%) and those with dysentery (9.4%). Compared to children not treated with antibiotics, those who received antibiotics had a lower frequency of PD overall (7.4% vs 10.1%, P = .01), and particularly among those with WD (6.3% vs 10.0%; P = .01) but not among children with dysentery (8.5% vs 11.0%; P = .27). For those with watery PD, Cryptosporidium and norovirus had the highest AFs among infants (0.16 and 0.12, respectively), while Shigella had the highest AF (0.25) in older children. The odds of PD decreased significantly over time in Mali and Kenya while increasing significantly in The Gambia. Conclusions: The burden of PD endures in sub-Saharan Africa, with nearly 10% of episodes of WD and dysentery becoming persistent. Competing Interests: Potential conflicts of interest. S. M. T. reports multiple grants paid to her institution from the National Institutes of Health, the Bill & Melinda Gates Foundation, Wellcome Trust, Affinivax, Lumen Biosciences, PATH, and the Medical Research Council. S. M. T. also reports payments as royalties related to intellectual property for Salmonella vaccines and Klebsiella/Pseudomonas vaccines; consulting fees and travel support from the University of Washington for a grant proposal; multiple planned, issued, and pending patents on Salmonella, Klebsiella, and Pseudomonas vaccines; and multiple unpaid committee roles with the American Society of Tropical Medicine and Hygiene. K. L. K. reports consultation fees and travel support from PATH and the University of Washington related to diarrheal diseases and grant support to her institution from the National Institute of Allergy and Infections Diseases, Institut Pasteur, and the Bill & Melinda Gates Foundation. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| References: | Scand J Infect Dis. 1990;22(3):259-67. (PMID: 2371542) Lancet. 2020 Oct 17;396(10258):1223-1249. (PMID: 33069327) J Infect Dis. 1997 Jun;175(6):1527-30. (PMID: 9180200) Clin Infect Dis. 2012 Dec;55 Suppl 4:S232-45. (PMID: 23169936) J Infect Dis. 2000 May;181(5):1643-51. (PMID: 10823764) BMC Public Health. 2021 Oct 23;21(1):1926. (PMID: 34688267) PLoS One. 2013 May 29;8(5):e64636. (PMID: 23734210) Gastroenterology. 2010 Oct;139(4):1156-64. (PMID: 20638937) Am J Epidemiol. 1997 Aug 1;146(3):273-82. (PMID: 9247012) Am J Trop Med Hyg. 2017 Jul;97(1):248-258. (PMID: 28719331) BMC Pediatr. 2022 Jul 1;22(1):385. (PMID: 35778675) J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S848-S855. (PMID: 34528677) Acta Paediatr Suppl. 1992 Sep;381:15-21. (PMID: 1421934) Clin Infect Dis. 2012 Dec;55 Suppl 4:S246-53. (PMID: 23169937) Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):65-8. (PMID: 10492794) Pediatr Infect Dis J. 1993 Sep;12(9):751-61; discussion 762-4. (PMID: 8414804) Paediatr Int Child Health. 2018 May;38(2):87-96. (PMID: 28475437) Lancet. 2021 Sep 4;398(10303):870-905. (PMID: 34416195) J Glob Health. 2019 Dec;9(2):020801. (PMID: 31673345) Pediatrics. 1984 Jun;73(6):799-805. (PMID: 6374599) PLoS One. 2010 Apr 28;5(4):e10386. (PMID: 20442848) Clin Infect Dis. 2023 Apr 19;76(Supplement_1):S5-S11. (PMID: 37074428) Bull World Health Organ. 1988;66(6):709-17. (PMID: 3266111) Acta Paediatr (Stockh). 1992 Sep;81 Suppl 381:3-6. (PMID: 12286021) Lancet. 2013 Jul 20;382(9888):209-22. (PMID: 23680352) Lancet. 2016 Sep 24;388(10051):1291-301. (PMID: 27673470) Lancet. 1988 Sep 3;2(8610):552-5. (PMID: 2900931) PLoS One. 2012;7(5):e36436. (PMID: 22590543) Int J Epidemiol. 1990 Sep;19(3):728-35. (PMID: 2262271) Cell Microbiol. 2019 Nov;21(11):e13067. (PMID: 31194282) BMC Infect Dis. 2016 Sep 06;16:477. (PMID: 27600526) Lancet. 1989 Aug 5;2(8658):319-22. (PMID: 2569114) Indian J Pediatr. 2012 Apr;79(4):472-7. (PMID: 21948223) Turk J Pediatr. 2009 Mar-Apr;51(2):133-40. (PMID: 19480324) Clin Infect Dis. 2012 Dec;55 Suppl 4:S294-302. (PMID: 23169941) Acta Paediatr. 2012 Oct;101(10):e452-7. (PMID: 22734659) EBioMedicine. 2021 Apr;66:103310. (PMID: 33862589) Lancet Glob Health. 2019 May;7(5):e568-e584. (PMID: 31000128) JAMA. 2016 Jun 28;315(24):2712-23. (PMID: 27357241) Vaccines (Basel). 2022 Mar 07;10(3):. (PMID: 35335035) J Pediatr Gastroenterol Nutr. 1991 Jan;12(1):82-8. (PMID: 2061784) Am J Trop Med Hyg. 1999 Nov;61(5):707-13. (PMID: 10586898) J Pediatr Gastroenterol Nutr. 2008 Aug;47(2):260-5. (PMID: 18664885) Am J Epidemiol. 1990 Jul;132(1):144-56. (PMID: 2192547) Indian J Gastroenterol. 2001 Mar-Apr;20(2):59-61. (PMID: 11305492) Am J Trop Med Hyg. 2003 Jun;68(6):671-7. (PMID: 12892051) |
| فهرسة مساهمة: | Keywords: diarrhea; dysentery; global; infection; persistent |
| المشرفين على المادة: | 0 (Rotavirus Vaccines) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20230419 Date Completed: 20230421 Latest Revision: 20230422 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10116565 |
| DOI: | 10.1093/cid/ciad022 |
| PMID: | 37074436 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
|---|---|
| DOI: | 10.1093/cid/ciad022 |