دورية أكاديمية
Peak width of skeletonized mean diffusivity and cognitive performance in cerebral amyloid angiopathy.
العنوان: | Peak width of skeletonized mean diffusivity and cognitive performance in cerebral amyloid angiopathy. |
---|---|
المؤلفون: | Horn MJ; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Gokcal E; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Becker JA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States., Das AS; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., Schwab K; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Zanon Zotin MC; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States.; Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, Center for Imaging Sciences and Medical Physics, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Goldstein JN; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Rosand J; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Viswanathan A; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Polimeni JR; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States., Duering M; Medical Image Analysis Center (MIAC), Department of Biomedical Engineering, University of Basel, Basel, Switzerland., Greenberg SM; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Gurol ME; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States. |
المصدر: | Frontiers in neuroscience [Front Neurosci] 2023 Apr 03; Vol. 17, pp. 1141007. Date of Electronic Publication: 2023 Apr 03 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
مستخلص: | Background: Cerebral Amyloid Angiopathy (CAA) is a cerebral small vessel disease that can lead to microstructural disruption of white matter (WM), which can be measured by the Peak Width of Skeletonized Mean Diffusivity (PSMD). We hypothesized that PSMD measures would be increased in patients with CAA compared to healthy controls (HC), and increased PSMD is associated with lower cognitive scores in patients with CAA. Methods: Eighty-one probable CAA patients without cognitive impairment who were diagnosed with Boston criteria and 23 HCs were included. All subjects underwent an advanced brain MRI with high-resolution diffusion-weighted imaging (DWI). PSMD scores were quantified from a probabilistic skeleton of the WM tracts in the mean diffusivity (MD) image using a combination of fractional anisotropy (FA) and the FSL Tract-Based Spatial Statistics (TBSS) algorithm (www.psmd-marker.com). Within CAA cohort, standardized z-scores of processing speed, executive functioning and memory were obtained. Results: The mean of age and sex were similar between CAA patients (69.6 ± 7.3, 59.3% male) and HCs (70.6 ± 8.5, 56.5% male) ( p = 0.581 and p = 0.814). PSMD was higher in the CAA group [(4.13 ± 0.94) × 10 -4 mm 2 /s] compared to HCs [(3.28 ± 0.51) × 10 -4 mm 2 /s] ( p < 0.001). In a linear regression model corrected for relevant variables, diagnosis of CAA was independently associated with increased PSMD compared to HCs ( ß = 0.45, 95% CI 0.13-0.76, p = 0.006). Within CAA cohort, higher PSMD was associated with lower scores in processing speed ( p < 0.001), executive functioning ( p = 0.004), and memory (0.047). Finally, PSMD outperformed all other MRI markers of CAA by explaining most of the variance in models predicting lower scores in each cognitive domain. Discussion: Peak Width of Skeletonized Mean Diffusivity is increased in CAA, and it is associated with worse cognitive scores supporting the view that disruption of white matter has a significant role in cognitive impairment in CAA. As a robust marker, PSMD can be used in clinical trials or practice. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Horn, Gokcal, Becker, Das, Schwab, Zanon Zotin, Goldstein, Rosand, Viswanathan, Polimeni, Duering, Greenberg and Gurol.) |
References: | Lancet Neurol. 2013 Aug;12(8):822-38. (PMID: 23867200) J Neurosci. 2014 Nov 12;34(46):15425-36. (PMID: 25392509) Alzheimers Dement. 2020 Dec;16(12):1714-1733. (PMID: 33030307) J Neurosci. 2011 Jan 26;31(4):1204-12. (PMID: 21273405) Neuroimage Clin. 2020;27:102280. (PMID: 32521475) Neurology. 2016 Feb 9;86(6):505-11. (PMID: 26747886) Int J Stroke. 2023 Jan;18(1):78-84. (PMID: 35473418) AJNR Am J Neuroradiol. 2021 May;42(5):875-881. (PMID: 33664113) Stroke. 2020 Jan;51(1):29-37. (PMID: 31752614) Neuroimage. 2006 Jul 1;31(3):1116-28. (PMID: 16545965) Neurology. 2014 Jul 22;83(4):304-11. (PMID: 24951477) Alzheimers Dement (Amst). 2019 Feb 26;11:191-204. (PMID: 30859119) J Neurosci. 2010 Jun 2;30(22):7569-74. (PMID: 20519531) Front Neurosci. 2013 Mar 12;7:31. (PMID: 23486659) Front Neurosci. 2022 Nov 11;16:1051038. (PMID: 36440281) Neurology. 2017 Jun 6;88(23):2162-2168. (PMID: 28476760) J Intern Med. 2004 Sep;256(3):183-94. (PMID: 15324362) Neurology. 1993 Oct;43(10):2073-9. (PMID: 8413970) Neurology. 2021 Mar 23;96(12):e1646-e1654. (PMID: 33536272) Lancet Neurol. 2009 Feb;8(2):165-74. (PMID: 19161908) Brain. 2016 Dec;139(Pt 12):3151-3162. (PMID: 27645801) Neurology. 2010 Apr 27;74(17):1346-50. (PMID: 20421578) Neuroimage. 2008 Aug 15;42(2):1032-44. (PMID: 18602840) Neuroimage. 2019 Nov 15;202:116137. (PMID: 31473352) Brain. 2015 Jan;138(Pt 1):179-88. (PMID: 25367025) Neurology. 2001 Feb 27;56(4):537-9. (PMID: 11222803) Stroke. 2006 Jul;37(7):1759-64. (PMID: 16763176) Neurology. 1984 Jul;34(7):939-44. (PMID: 6610841) Ann Neurol. 2013 Apr;73(4):529-36. (PMID: 23424091) J Am Heart Assoc. 2019 Feb 5;8(3):e011288. (PMID: 30717612) Neuroimage. 2009 Mar;45(1 Suppl):S173-86. (PMID: 19059349) Brain. 2015 Aug;138(Pt 8):2126-39. (PMID: 26115675) Hum Brain Mapp. 2016 Jan;37(1):300-10. (PMID: 26466741) Neuroimage. 2016 Jan 15;125:1063-1078. (PMID: 26481672) Stroke. 2018 Oct;49(10):2330-2336. (PMID: 30355109) Ann Neurol. 2016 Oct;80(4):581-92. (PMID: 27518166) Front Psychiatry. 2020 May 04;11:342. (PMID: 32425831) |
معلومات مُعتمدة: | K23 NS083711 United States NS NINDS NIH HHS; R01 NS114526 United States NS NINDS NIH HHS |
فهرسة مساهمة: | Keywords: cerebral amyloid angiopathy (CAA); cerebral small vessel disease; cognitive functions; diffusion-weighted imaging; peak width of skeletonized mean diffusivity (PSMD) |
تواريخ الأحداث: | Date Created: 20230420 Latest Revision: 20240308 |
رمز التحديث: | 20240308 |
مُعرف محوري في PubMed: | PMC10106761 |
DOI: | 10.3389/fnins.2023.1141007 |
PMID: | 37077322 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1662-4548 |
---|---|
DOI: | 10.3389/fnins.2023.1141007 |