دورية أكاديمية
أعرض في EDS

Peak width of skeletonized mean diffusivity and cognitive performance in cerebral amyloid angiopathy.

التفاصيل البيبلوغرافية
العنوان: Peak width of skeletonized mean diffusivity and cognitive performance in cerebral amyloid angiopathy.
المؤلفون: Horn MJ; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Gokcal E; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Becker JA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States., Das AS; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., Schwab K; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Zanon Zotin MC; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States.; Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, Center for Imaging Sciences and Medical Physics, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Goldstein JN; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Rosand J; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Viswanathan A; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Polimeni JR; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States., Duering M; Medical Image Analysis Center (MIAC), Department of Biomedical Engineering, University of Basel, Basel, Switzerland., Greenberg SM; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States., Gurol ME; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States.
المصدر: Frontiers in neuroscience [Front Neurosci] 2023 Apr 03; Vol. 17, pp. 1141007. Date of Electronic Publication: 2023 Apr 03 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Background: Cerebral Amyloid Angiopathy (CAA) is a cerebral small vessel disease that can lead to microstructural disruption of white matter (WM), which can be measured by the Peak Width of Skeletonized Mean Diffusivity (PSMD). We hypothesized that PSMD measures would be increased in patients with CAA compared to healthy controls (HC), and increased PSMD is associated with lower cognitive scores in patients with CAA.
Methods: Eighty-one probable CAA patients without cognitive impairment who were diagnosed with Boston criteria and 23 HCs were included. All subjects underwent an advanced brain MRI with high-resolution diffusion-weighted imaging (DWI). PSMD scores were quantified from a probabilistic skeleton of the WM tracts in the mean diffusivity (MD) image using a combination of fractional anisotropy (FA) and the FSL Tract-Based Spatial Statistics (TBSS) algorithm (www.psmd-marker.com). Within CAA cohort, standardized z-scores of processing speed, executive functioning and memory were obtained.
Results: The mean of age and sex were similar between CAA patients (69.6 ± 7.3, 59.3% male) and HCs (70.6 ± 8.5, 56.5% male) ( p = 0.581 and p = 0.814). PSMD was higher in the CAA group [(4.13 ± 0.94) × 10 -4 mm 2 /s] compared to HCs [(3.28 ± 0.51) × 10 -4 mm 2 /s] ( p < 0.001). In a linear regression model corrected for relevant variables, diagnosis of CAA was independently associated with increased PSMD compared to HCs ( ß = 0.45, 95% CI 0.13-0.76, p = 0.006). Within CAA cohort, higher PSMD was associated with lower scores in processing speed ( p < 0.001), executive functioning ( p = 0.004), and memory (0.047). Finally, PSMD outperformed all other MRI markers of CAA by explaining most of the variance in models predicting lower scores in each cognitive domain.
Discussion: Peak Width of Skeletonized Mean Diffusivity is increased in CAA, and it is associated with worse cognitive scores supporting the view that disruption of white matter has a significant role in cognitive impairment in CAA. As a robust marker, PSMD can be used in clinical trials or practice.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Horn, Gokcal, Becker, Das, Schwab, Zanon Zotin, Goldstein, Rosand, Viswanathan, Polimeni, Duering, Greenberg and Gurol.)
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معلومات مُعتمدة: K23 NS083711 United States NS NINDS NIH HHS; R01 NS114526 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: cerebral amyloid angiopathy (CAA); cerebral small vessel disease; cognitive functions; diffusion-weighted imaging; peak width of skeletonized mean diffusivity (PSMD)
تواريخ الأحداث: Date Created: 20230420 Latest Revision: 20240308
رمز التحديث: 20240308
مُعرف محوري في PubMed: PMC10106761
DOI: 10.3389/fnins.2023.1141007
PMID: 37077322
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-4548
DOI:10.3389/fnins.2023.1141007