دورية أكاديمية
ChemBeads-Enabled Photoredox High-Throughput Experimentation Platform to Improve C(sp 2 )-C(sp 3 ) Decarboxylative Couplings.
| العنوان: | ChemBeads-Enabled Photoredox High-Throughput Experimentation Platform to Improve C(sp 2 )-C(sp 3 ) Decarboxylative Couplings. |
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| المؤلفون: | Gesmundo NJ; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Tu NP; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Sarris KA; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wang Y; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States. |
| المصدر: | ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Mar 16; Vol. 14 (4), pp. 521-529. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مستخلص: | Enthusiasm surrounding nickel/photoredox C(sp 2 )-C(sp 3 ) cross-couplings is very high; however, these methods are sometimes challenged by complex drug-like substrates in discovery chemistry. In our hands this has been especially true of the decarboxylative coupling, which has lagged behind other photoredox couplings in internal adoption and success. Herein, the development of a photoredox high-throughput experimentation platform to optimize challenging C(sp 2 )-C(sp 3 ) decarboxylative couplings is described. Chemical-coated glass beads (ChemBeads) and a novel parallel bead dispenser are used to expedite the high-throughput experimentation process and identify improved coupling conditions. In this report, photoredox high-throughput experimentation is utilized to dramatically improve low-yielding decarboxylative C(sp 2 )-C(sp 3 ) couplings, and libraries, using conditions not previously identified in the literature. Competing Interests: The authors declare no competing financial interest. (© 2023 American Chemical Society.) |
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| تواريخ الأحداث: | Date Created: 20230420 Latest Revision: 20240414 |
| رمز التحديث: | 20240414 |
| مُعرف محوري في PubMed: | PMC10108395 |
| DOI: | 10.1021/acsmedchemlett.2c00538 |
| PMID: | 37077401 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1948-5875 |
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| DOI: | 10.1021/acsmedchemlett.2c00538 |