دورية أكاديمية
أعرض في EDS

Triterpene and Steroids from Ludwigia abyssinica A. Rich (Onagraceae) Displayed Antimicrobial Activities and Synergistic Effects with Conventional Antibiotics.

التفاصيل البيبلوغرافية
العنوان: Triterpene and Steroids from Ludwigia abyssinica A. Rich (Onagraceae) Displayed Antimicrobial Activities and Synergistic Effects with Conventional Antibiotics.
المؤلفون: Meli Sonkoue A; Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Kengne IC; Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Tamekou Lacmata S; Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Jouogo Ngnokam CD; Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Djamalladine Djamalladine M; Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Voutquenne-Nazabadioko L; Groupe Isolement et Structure, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, Bat. 18 B.P. 1039, 51687 Reims Cedex 2, Reims, France., Ngnokam D; Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Tamokou JD; Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2023 Apr 10; Vol. 2023, pp. 2975909. Date of Electronic Publication: 2023 Apr 10 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: Difficulties encountered in treating drug-resistant pathogens have created a need for new therapies. Synergistic combinations of antibiotics are considered as ideal strategies in combating clinical and multidrug-resistant (MDR) infections. In this study, the antimicrobial activities of triterpenes and steroids from Ludwigia abyssinica A. Rich (Onagraceae) and their combined effects with antibiotics were assessed. The associations between plant constituents and antibiotics were evaluated by determining their fractional inhibitory concentrations (FICs). Sitost-5-en-3 β -ol formiate ( 1 ), 5 α ,6 β -dihydroxysitosterol ( 2 ), and maslinic acid ( 3 ) were isolated from the L. abyssinica ethyl acetate (EtOAc) extract. The EtOAc extract, compounds 1, 2, and 3 (MIC = 16-128  µ g/mL) would be the best antibacterial and antifungal agents. The antimicrobial activities of amoxicillin were relatively weak against MDR Escherichia coli and Shigella flexneri and significant against Staphylococcus aureus ATCC 25923. However, when used in association with plant constituents, it displayed an interesting synergistic effect. Among plant components-antibiotic combinations, the EtOAc extract and compound 1 (steroid) showed a synergistic effect with amoxicillin/fluconazole against all the tested microorganisms whereas the association of compound 3 (triterpenoid) and amoxicillin/fluconazole displayed an additive effect against Shigella flexneri and Escherichia coli and a synergistic effect on Staphylococcus aureus , Cryptococcus neoformans , Candida tropicalis , and Candida albicans ATCC 10231. Overall, the results of the present study demonstrated antibacterial and antifungal activities of extracts and compounds isolated from L. abyssinica. The findings of the current study also showed that the potency of antibiotics was improved when screened in combination with L. abyssinica components, supporting the drug combination strategy to combat antimicrobial resistance.
Competing Interests: The authors declare that there are no conflicts of interest with regard to the publication of this article.
(Copyright © 2023 Arlette Meli Sonkoue et al.)
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تواريخ الأحداث: Latest Revision: 20230421
رمز التحديث: 20230421
مُعرف محوري في PubMed: PMC10110380
DOI: 10.1155/2023/2975909
PMID: 37078065
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2023/2975909