دورية أكاديمية
أعرض في EDS

Chronic troponin elevation assessed by myocardial T1 mapping in patients with stable coronary artery disease.

التفاصيل البيبلوغرافية
العنوان: Chronic troponin elevation assessed by myocardial T1 mapping in patients with stable coronary artery disease.
المؤلفون: Segre CAW; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., de Lemos JA; Division of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Assunção Junior AN; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Nomura CH; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Favarato D; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Strunz CMC; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Villa AV; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Parga Filho JR; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Rezende PC; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Hueb W; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Ramires JAF; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Kalil Filho R; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil., Serrano Junior CV; Heart Institute (InCor) University of São Paulo Clinics Hospital, Sao Paulo, Brazil.
المصدر: Medicine [Medicine (Baltimore)] 2023 Apr 21; Vol. 102 (16), pp. e33548.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Coronary Artery Disease*/diagnosis , Coronary Artery Disease*/pathology, Humans ; Contrast Media ; Troponin I ; Magnetic Resonance Imaging, Cine ; Gadolinium ; Myocardium/pathology ; Fibrosis ; Ventricular Function, Left ; Predictive Value of Tests
مستخلص: Background: Cardiac troponin detected with sensitive assays can be chronically elevated, in the absence of unstable coronary syndromes. In patients with chronic coronary artery disease, clinically silent ischemic episodes may cause chronic troponin release. T1 mapping is a cardiovascular magnetic resonance technique useful in quantitative cardiac tissue characterization. We selected patients with anatomically and functionally normal hearts to investigate associations between chronic troponin release and myocardial tissue characteristics assessed by T1 mapping.
Methods: We investigated the relationship between cardiac troponin I concentrations and cardiovascular magnetic resonance T1 mapping parameters in patients with stable coronary artery disease enrolled in MASS V study before elective revascularization. Participants had no previous myocardial infarction, negative late gadolinium enhancement, normal left ventricular function, chamber dimensions and wall thickness.
Results: A total of 56 patients were analyzed in troponin tertiles: nativeT1 and extracellular volume (ECV) values (expressed as means ± standard deviations) increased across tertiles: nativeT1 (1006 ± 27 ms vs 1016 ± 27 ms vs 1034 ± 37 ms, ptrend = 0.006) and ECV (22 ± 3% vs 23 ± 1.9% vs 25 ± 3%, ptrend = 0.007). Cardiac troponin I concentrations correlated with native T1(R = 0.33, P = .012) and ECV (R = 0.3, P = .025), and were independently associated with nativeT1 (P = .049) and ventricular mass index (P = .041) in multivariable analysis.
Conclusion: In patients with chronic coronary artery disease and structurally normal hearts, troponin I concentrations correlated with T1 mapping parameters, suggesting that diffuse edema or fibrosis scattered in normal myocardium might be associated with chronic troponin release.
Competing Interests: The authors have no funding and conflicts of interest to disclose.
(Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
References: Aw TC, Huang WT, Le TT, et al. High-sensitivitycardiac troponinsin cardio-healthy subjects: a cardiovascular magnetic resonance imaging study. Sci Rep. 2018;8:15409.
Apple FS, Ler R, Murakami MM. Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population. Clin Chem. 2012;58:1574–81.
Segre CA, Hueb W, Garcia RM, et al. Troponin in diabetic patients with and without chronic coronary artery disease. BMC Cardiovasc Disord. 2015;15:72.
Omland T, de Lemos JA, Sabatine MS, et al. A sensitive cardiac troponin T assay in stable coronary artery disease. N Engl J Med. 2009;361:2538–47.
Omland T, Pfeffer MA, Solomon SD, et al. Prognostic value of cardiac troponin I measured with a highly sensitive assay in patients with stable coronary artery disease. J Am Coll Cardiol. 2013;61:1240–9.
Giannitsis E, Spanuth E, Horsch A, et al. High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide predict mortality in stable coronary artery disease: results from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Clin Chem Lab Med. 2013;51:2019–28.
Kociol RD, Pang PS, Gheorghiade M, et al. Troponin elevation in heart failure prevalence, mechanisms, and clinical implications. J Am Coll Cardiol. 2010;56:1071–8.
Frencken JF, van Baal L, Kappen TH, et al. Myocardial injury in critically ill patients with community-acquired pneumonia. a cohort study. Ann Am Thorac Soc. 2019;16:606–12.
Korosoglou G, Lehrke S, Mueller D, et al. Determinants of troponin release in patients with stable coronary artery disease: insights from CT angiography characteristics of atherosclerotic plaque. Heart. 2011;97:823–31.
Adam RD, Shambrook J, Flett AS. The prognostic role of tissue characterisation using cardiovascular magnetic resonance in heart failure. Card Fail Rev. 2017;3:86–96.
Mewton N, Liu CY, Croisille P, et al. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol. 2011;57:891–903.
Fernandes JL, Rochitte CE. T1 mapping: technique and applications. Magn Reson Imaging Clin N Am. 2015;23:25–34.
Messroghli DR, Moon JC, Ferreira VM, et al. Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: a consensus statement by the society for cardiovascular magnetic resonance (SCMR) endorsed by the European association for cardiovascular imaging (EACVI). J Cardiovasc Magn Reson. 2017;19:75.
Puntmann VO, Peker E, Chandrashekhar Y, et al. T1 mapping in characterizing myocardial disease: a comprehensive review. Circ Res. 2016;119:277–99.
Haaf P, Garg P, Messroghli DR, et al. Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: a comprehensive review. J Cardiovasc Magn Reson. 2016;18:89.
Ugander M, Oki AJ, Hsu LY, et al. Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur Heart J. 2012;33:1268–78.
Puntmann VO, Carr-White G, Jabbour A, et al. Native T1 and ECV of noninfarcted myocardium and outcome in patients with coronary artery disease. J Am Coll Cardiol. 2018;71:766–78.
Shanmuganathan M, Masi A, Burrage MK, et al. Acute response in the noninfarcted myocardium predicts long-term major adverse cardiac events after STEMI. JACC Cardiovasc Imag. 2023;16:46–59.
Hueb W, Gersh BJ, Rezende PC, et al. Hypotheses, rationale, design, and methods for prognostic evaluation of cardiac biomarker elevation after percutaneous and surgical revascularization in the absence of manifest myocardial infarction. A comparative analysis of biomarkers and cardiac magnetic resonance. The MASS-V Trial. BMC Cardiovasc Disord. 2012;12:65.
Wong TC, Piehler KM, Kang IA, et al. Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission. Eur Heart J. 2014;35:657–64.
Apple FS. A new season for cardiac troponin assays: it’s time to keep a scorecard. Clin Chem. 2009;55:1303–6.
Neilan TG, Coelho-Filho OR, Shah RV, et al. Myocardial extracellular volume fraction from T1 measurements in healthy volunteers and mice: relationship to aging and cardiac dimensions. JACC Cardiovasc Imag. 2013;6:672–83.
Kawel-Boehm N, Maceira A, Valsangiacomo-Buechel ER, et al. Normal values for cardiovascular magnetic resonance in adults and children. J Cardiovasc Magn Reson. 2015;17:29.
Messroghli DR, Walters K, Plein S, et al. Myocardial T1 mapping: application to patients with acute and chronic myocardial infarction. Magn Reson Med. 2007;58:34–40.
Yang EY, Khan MA, Graviss EA, et al. Relationship of extracellular volume assessed on cardiac magnetic resonance and serum cardiac troponins and natriuretic peptides with heart failure outcomes. Sci Rep. 2019;9:20168.
Chen S, Huang L, Zhang Q, et al. T2-weighted cardiac magnetic resonance image and myocardial biomarker in hypertrophic cardiomyopathy. Medicine (Baltim). 2020;99:e20134e20134.
Seliger SL, Hong SN, Christenson RH, et al. High-sensitive cardiac troponin t as an early biochemical signature for clinical and subclinical heart failure: MESA (multi-ethnic study of atherosclerosis). Circulation. 2017;135:1494–505.
Yan I, Borschel CS, Neumann JT, et al. High-sensitivity cardiac troponin i levels and prediction of heart failure: results from the BiomarCaRE consortium. JACC Heart Fail. 2020;8:401–11.
Ellims AH, Iles LM, Ling LH, et al. Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction. J Cardiovascular Magnetic Resonance. 2012;14:76.
Ng AC, Auger D, Delgado V, et al. Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T (1) mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study. Circ Cardiovasc Imag. 2012;5:51–9.
Melki D, Lugnegard J, Alfredsson J, et al. Implications of introducing high-sensitivity cardiac troponin T into clinical practice: data from the SWEDEHEART registry. J Am Coll Cardiol. 2015;65:1655–64.
Hallen J, Johansen OE, Birkeland KI, et al. Determinants and prognostic implications of cardiac troponin T measured by a sensitive assay in type 2 diabetes mellitus. Cardiovasc Diabetol. 2010;9:52.
Everett BM, Cook NR, Magnone MC, et al. Sensitive cardiac troponin T assay and the risk of incident cardiovascular disease in women with and without diabetes mellitus: the women’s health study. Circulation. 2011;123:2811–8.
Cimaglia P, Dalla Paola L, Carone A, et al. High-sensitivity cardiac troponin predicts major cardiovascular events in diabetic patients with critical limb ischemia and foot lesions. Front Cardiovasc Med. 2021;8:595701.
Laakso M. Heart in diabetes: a microvascular disease. Diabetes Care. 2011;34 Suppl 2(Suppl 2):S145–149.
Siciliano M, Mettimano M, Dondolini-Poli A, et al. Troponin I serum concentration: a new marker of left ventricular hypertrophy in patients with essential hypertension. Ital Heart J. 2000;1:532–5.
Salerno M, Kramer CM. Advances in parametric mapping with CMR imaging. JACC. Cardiovascular Imag. 2013;6:806–22.
Liu CY, Liu YC, Wu C, et al. Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (multi-ethnic study of atherosclerosis). J Am Coll Cardiol. 2013;62:1280–7.
Wong TC, Piehler K, Meier CG, et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation. 2012;126:1206–16.
Fontana M, White SK, Banypersad SM, et al. Comparison of T1 mapping techniques for ECV quantification. Histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR. J Cardiovasc Magn Reson. 2012;14:88.
Perea RJ, Ortiz-Perez JT, Sole M, et al. T1 mapping: characterisation of myocardial interstitial space. Insights Imag. 2015;6:189–202.
المشرفين على المادة: 0 (Contrast Media)
0 (Troponin I)
AU0V1LM3JT (Gadolinium)
تواريخ الأحداث: Date Created: 20230421 Date Completed: 20230425 Latest Revision: 20230916
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10118361
DOI: 10.1097/MD.0000000000033548
PMID: 37083772
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5964
DOI:10.1097/MD.0000000000033548