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The use of specific antihypertensive medication and skin cancer risk: A systematic review of the literature and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: The use of specific antihypertensive medication and skin cancer risk: A systematic review of the literature and meta-analysis.
المؤلفون: Heisel AGU; Department of Internal Medicine, Section of Nephrology, Amsterdam University Medical Centres, location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, The Netherlands., Vuurboom MD; Department of Internal Medicine, Section of Nephrology, Amsterdam University Medical Centres, location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, The Netherlands., Daams JG; Medical Library, Amsterdam University Centres, Amsterdam, the Netherlands., de Rie MA; Department of Dermatology, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Vogt L; Department of Internal Medicine, Section of Nephrology, Amsterdam University Medical Centres, location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, The Netherlands., van den Born BH; Department of Internal Medicine, section Vascular Medicine, Amsterdam University Medical Centres, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic syndromes, Amsterdam, The Netherlands., Olde Engberink RHG; Department of Internal Medicine, Section of Nephrology, Amsterdam University Medical Centres, location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, The Netherlands. Electronic address: r.h.oldeengberink@amsterdamumc.nl.
المصدر: Vascular pharmacology [Vascul Pharmacol] 2023 Jun; Vol. 150, pp. 107173. Date of Electronic Publication: 2023 Apr 20.
نوع المنشور: Systematic Review; Meta-Analysis; Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3649 (Electronic) Linking ISSN: 15371891 NLM ISO Abbreviation: Vascul Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier Science, c2002-
مواضيع طبية MeSH: Skin Neoplasms*/chemically induced , Skin Neoplasms*/epidemiology , Skin Neoplasms*/drug therapy , Melanoma*/chemically induced , Melanoma*/epidemiology , Melanoma*/drug therapy , Hypertension*/diagnosis , Hypertension*/drug therapy , Hypertension*/epidemiology, Humans ; Antihypertensive Agents/adverse effects ; Hydrochlorothiazide/adverse effects ; Diuretics/adverse effects
مستخلص: Background: The use of hydrochlorothiazide has recently been linked to skin cancer in observational studies. This may be explained by its photosensitizing properties, but photosensitivity has also been reported for other antihypertensive drugs. We conducted a systematic review and meta-analysis to compare skin cancer risk among antihypertensive drug classes and individual blood pressure lowering drugs.
Methods: We searched Medline, Embase, Cochrane and the Web of Science and included studies that investigated the association between antihypertensive medication exposure and non-melanoma skin cancer (NMSC) or cutaneous malignant melanoma (CMM). We combined the extracted odds ratios (OR) using a random effects model.
Results: We included 42 studies with a total of 16,670,045 subjects. Diuretics, in particular hydrochlorothiazide, were examined most frequently. Only 2 studies provided information about antihypertensive co-medication. Exposure to diuretics (OR 1.27 [1.09-1.47]) and calcium channel blockers (OR 1.06 [1.04-1.09]) was associated with an increased risk for NMSC. The increased risk for NMSC was only observed in case control studies and studies that did not correct for sun exposure, skin phototype or smoking. Studies that did correct for covariates as well as cohort studies did not show a significantly increased risk for NMSC. Egger's test revealed a significant publication bias for the subgroup of diuretics, hydrochlorothiazide and case-control studies concerning NMSC (p < 0.001).
Conclusion: The available studies investigating the potential skin cancer risk that is associated with antihypertensive medication have significant shortcomings. Also, a significant publication bias is present. We found no increased skin cancer risk when analyzing cohort studies or studies that corrected for important covariates. (PROSPERO (CRD42020138908)).
Competing Interests: Declaration of Competing Interest No conflicts of interest.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Antihypertensive; Hydrochlorothiazide; Hypertension; Skin; cancer
المشرفين على المادة: 0 (Antihypertensive Agents)
0J48LPH2TH (Hydrochlorothiazide)
0 (Diuretics)
تواريخ الأحداث: Date Created: 20230421 Date Completed: 20230607 Latest Revision: 20230620
رمز التحديث: 20231215
DOI: 10.1016/j.vph.2023.107173
PMID: 37084802
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-3649
DOI:10.1016/j.vph.2023.107173