دورية أكاديمية
أعرض في EDS

Upregulation of IL-33, CCL2, and CXCL16 levels in Brazilian pregnant women infected by Toxoplasma gondii.

التفاصيل البيبلوغرافية
العنوان: Upregulation of IL-33, CCL2, and CXCL16 levels in Brazilian pregnant women infected by Toxoplasma gondii.
المؤلفون: Santos PVD; Immunobiology Laboratory of Inflammation, Department of Biological Sciences/ ICEB, Federal University Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Health and Nutrition, Federal University Ouro Preto, Ouro Preto, MG, Brazil., Toledo DNM; Immunobiology Laboratory of Inflammation, Department of Biological Sciences/ ICEB, Federal University Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Health and Nutrition, Federal University Ouro Preto, Ouro Preto, MG, Brazil., Guimarães NS; Graduate Program in Health and Nutrition, Federal University Ouro Preto, Ouro Preto, MG, Brazil., Perucci LO; Immunobiology Laboratory of Inflammation, Department of Biological Sciences/ ICEB, Federal University Ouro Preto, Ouro Preto, MG, Brazil., Andrade-Neto VF; Laboratory of Malaria Biology and Toxoplasmosis, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Talvani A; Immunobiology Laboratory of Inflammation, Department of Biological Sciences/ ICEB, Federal University Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Health and Nutrition, Federal University Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Health Sciences, Infectology and Tropical Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: talvani@ufop.edu.br.
المصدر: Acta tropica [Acta Trop] 2023 Jul; Vol. 243, pp. 106931. Date of Electronic Publication: 2023 Apr 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Basel.
مواضيع طبية MeSH: Toxoplasma* , Toxoplasmosis*/epidemiology, Female ; Pregnancy ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Interleukin-17 ; Pregnant Women ; Up-Regulation ; Interleukin-33 ; Brazil/epidemiology ; Antibodies, Protozoan ; Seroepidemiologic Studies ; Immunoglobulin M ; Chemokine CXCL16 ; Chemokine CCL2
مستخلص: Congenital toxoplasmosis can cause neurological and eye damage, behavioral alterations, or death in fetuses or babies born to Toxoplasma gondii-infected women. Several pieces of evidence suggest that socioeconomic, environmental, and inflammatory patterns linked to the maternal immune response partly drive the pathogenesis of this disease. However, immunoregulation induced by T. gondii infection during gestation is not completely understood. The aim of this study was to assess the association between T. gondii seropositivity and concentrations of plasma markers (CCL2, CXCL16, IL-17, and IL-33) in Brazilian pregnant women. Inflammatory markers were measured by immunoassays in the plasma of 131 pregnant women (13 to 46 years old). The prevalence of T. gondii infections was 45.8% (n = 60) in this population. The concentrations of CCL2, CXCL16, and IL-33 were higher in T. gondii-seropositive than in seronegative pregnant women, while the opposite was observed for IL-17 levels. In IgG+ women, a strong correlation between IL-17 and IL-33 (r = 0.7508, p = 0.0001) and a moderate correlation between CXCL16/IL-17 (r = 0.7319, p = 0.0001) and CXCL16/CCL2 (r = 0.3519, p = 0.0098) was observed. In uninfected women, a strong correlation was found between IL-17 and CXCL16 (r = 0.6779, p = 0.0001) but moderate between IL-17 and IL-33 (r = 0.4820, p = 0.0001). In summary, our data suggest that plasma upregulation of CCL2, CXCL16, and IL-33 might exert a potential protective role in the mother/fetus/parasite axis and, in addition, multiparous women are more likely to be infected with T. gondii than primiparous women.
Competing Interests: Declaration of Competing Interest The authors declare this research was conducted without conflicts of interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: CCL2; CXCL16; IL-33; Pregnant women; Toxoplasma gondii
المشرفين على المادة: 0 (Interleukin-17)
0 (Interleukin-33)
0 (Antibodies, Protozoan)
0 (Immunoglobulin M)
0 (CXCL16 protein, human)
0 (Chemokine CXCL16)
0 (CCL2 protein, human)
0 (Chemokine CCL2)
تواريخ الأحداث: Date Created: 20230422 Date Completed: 20230529 Latest Revision: 20230529
رمز التحديث: 20231215
DOI: 10.1016/j.actatropica.2023.106931
PMID: 37086937
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6254
DOI:10.1016/j.actatropica.2023.106931