التفاصيل البيبلوغرافية
| العنوان: |
Dietary protein shapes the profile and repertoire of intestinal CD4 + T cells. |
| المؤلفون: |
Lockhart A, Reed A, de Castro TR, Herman C, Canesso MCC, Mucida D |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 13. Date of Electronic Publication: 2023 Apr 13. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4 + T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4 + T cells. Independent of the microbiota, dietary proteins contributed to accumulation and clonal selection of antigen-experienced CD4 + T cells at the intestinal epithelium, imprinting a tissue specialized transcriptional program including cytotoxic genes on both conventional and regulatory CD4 + T cells (Tregs). This steady state CD4 + T cell response to food was disrupted by inflammatory challenge, and protection against food allergy in this context was associated with Treg clonal expansion and decreased pro-inflammatory gene expression. Finally, we identified both steady state epithelium-adapted CD4 + T cells and tolerance-induced Tregs that recognize dietary antigens, suggesting that both cell types may be critical for preventing inappropriate immune responses to food. |
| التعليقات: |
Update in: J Exp Med. 2023 Aug 7;220(8):. (PMID: 37191720) |
| تواريخ الأحداث: |
Date Created: 20230424 Latest Revision: 20230614 |
| رمز التحديث: |
20231215 |
| مُعرف محوري في PubMed: |
PMC10120666 |
| DOI: |
10.1101/2023.04.11.536475 |
| PMID: |
37090529 |
| قاعدة البيانات: |
MEDLINE |
