دورية أكاديمية
أعرض في EDS

Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages.

التفاصيل البيبلوغرافية
العنوان: Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages.
المؤلفون: Smimih K; Biological Engineering Laboratory, Faculty of Sciences and Techniques (FST), Sultan Moulay Slimane University, Beni Mellal 23000, Morocco.; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco., El-Mansoury B; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco., Saad FE; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco., Khanouchi M; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco., El Amine S; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco., Aimrane A; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco., Zouhairi N; Biological Engineering Laboratory, Faculty of Sciences and Techniques (FST), Sultan Moulay Slimane University, Beni Mellal 23000, Morocco., Ferssiwi A; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco., Bitar A; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco., Merzouki M; Biological Engineering Laboratory, Faculty of Sciences and Techniques (FST), Sultan Moulay Slimane University, Beni Mellal 23000, Morocco., El Hiba O; Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco.
المصدر: Neurology international [Neurol Int] 2023 Apr 19; Vol. 15 (2), pp. 580-594. Date of Electronic Publication: 2023 Apr 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551564 Publication Model: Electronic Cited Medium: Print ISSN: 2035-8385 (Print) Linking ISSN: 20358385 NLM ISO Abbreviation: Neurol Int Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2020- : Basel, Switzerland : MDPI
Original Publication: Pavia, Italy : PagePress
مستخلص: Prenatal alcohol exposure (PAE) refers to fetal exposure to alcohol during pregnancy through placental barrier transfer from maternal blood. The postnatal outcomes of PAE differ among exposed individuals and range from overt (serious) alcohol-related behavioral and neurophysiological impairments to covert (silenced) symptoms. The aims of the present investigation were to assess the postnatal neurobehavioral disturbances, particularly, motor coordination and sensory-motor function in mice with PAE. Female mice with positive vaginal plugs were divided into three groups: group 1: Et + Pyr: received two i.p injections of ethanol (1 g/kg) followed by pyrazole (100 mg/kg). Group 2: Pyr: received an i.p injection of pyrazole (100 mg/kg). Group 3: C: of saline controls received, in equal volume, saline solution (NaCl 0.9%). After birth, mice pups were weighed and subjected to behavioral tests for motor function screening using the motor ambulation test, cliff aversion, surface righting, and negative geotaxis, while at the adult stage, mice were subjected to the open field, rotarod, parallel bars, and static rods tests. Our data show an obvious decrement of body weight from the first post-natal day (P1) and continues over the adult stage. This was accompanied by an obvious impaired sensory-motor function which was maintained even at the adult stage with alteration of the locomotor and coordination abilities. The current data demonstrate the powerful neurotoxic effect of prenatal ethanol exposure on the sensory-motor and coordination functions, leading to suppose possible structural and/or functional neuronal disturbances, particularly the locomotor network.
References: Neuropediatrics. 1987 Aug;18(3):158-60. (PMID: 3683756)
Neurol Int. 2023 Jan 28;15(1):162-187. (PMID: 36810468)
Alcohol Clin Exp Res. 1998 May;22(3):685-96. (PMID: 9622451)
Behav Brain Res. 2000 Nov 15;116(1):99-110. (PMID: 11090889)
Eur J Neurosci. 2004 Nov;20(10):2822-6. (PMID: 15548226)
Neuropharmacology. 2017 Sep 1;123:368-384. (PMID: 28669901)
Teratology. 1989 Aug;40(2):113-26. (PMID: 2772847)
Hepatology. 1998 Dec;28(6):1561-5. (PMID: 9828220)
Neuropsychopharmacology. 2015 Mar;40(4):893-905. (PMID: 25284318)
J Vis Exp. 2013 May 29;(75):e2609. (PMID: 23748408)
BMJ. 1991 Jul 6;303(6793):22-6. (PMID: 1859950)
Neurol Int. 2021 Nov 10;13(4):594-607. (PMID: 34842811)
Hippocampus. 2000;10(1):94-110. (PMID: 10706221)
Horm Behav. 1997 Jun;31(3):197-211. (PMID: 9213134)
Alcohol. 2007 Jun;41(4):239-51. (PMID: 17630085)
Reprod Toxicol. 2014 Jul;46:31-9. (PMID: 24568797)
J Neurosci. 2010 Jun 16;30(24):8285-95. (PMID: 20554880)
Neurobehav Toxicol Teratol. 1982 Sep-Oct;4(5):505-13. (PMID: 7177300)
Pediatrics. 2016 Aug;138(2):. (PMID: 27464676)
Alcohol Clin Exp Res. 1998 Feb;22(1):252-8. (PMID: 9514315)
Dev Disabil Res Rev. 2009;15(3):209-17. (PMID: 19731391)
Alcohol Clin Exp Res. 2009 Jun;33(6):1001-11. (PMID: 19302087)
Pharmacol Biochem Behav. 2006 Oct;85(2):345-55. (PMID: 17049371)
Alcohol Clin Exp Res. 2010 Apr;34(4):633-45. (PMID: 20102562)
Neuropediatrics. 1991 May;22(2):59-64. (PMID: 1713311)
Neurotoxicol Teratol. 1994 May-Jun;16(3):283-9. (PMID: 7935262)
Alcohol Clin Exp Res. 1999 Apr;23(4):726-34. (PMID: 10235310)
Physiol Behav. 2008 Jul 5;94(4):540-4. (PMID: 18486160)
Nat Neurosci. 2020 Apr;23(4):533-543. (PMID: 32203497)
Acta Paediatr Scand Suppl. 1979;275:112-21. (PMID: 291283)
Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):3-18. (PMID: 12732219)
Alcohol Clin Exp Res. 1990 Oct;14(5):650-5. (PMID: 2264592)
Neurotoxicol Teratol. 1988 Mar-Apr;10(2):175-80. (PMID: 3398826)
JAMA. 2018 Feb 6;319(5):474-482. (PMID: 29411031)
Behav Brain Res. 2011 Oct 1;223(2):376-87. (PMID: 21601595)
Alcohol Clin Exp Res. 2003 Dec;27(12):2009-16. (PMID: 14691390)
PLoS One. 2014 Jun 30;9(6):e101482. (PMID: 24978807)
Acta Paediatr Scand. 1985 Jan;74(1):20-6. (PMID: 3984723)
Drug Metab Dispos. 1987 Sep-Oct;15(5):634-9. (PMID: 2891479)
JAMA Pediatr. 2017 Oct 1;171(10):948-956. (PMID: 28828483)
J Vis Exp. 2015 Feb 06;(96):e52434. (PMID: 25742564)
Pediatrics. 2015 Jan;135(1):e52-8. (PMID: 25535260)
Alcohol Clin Exp Res. 2016 Jan;40(1):122-33. (PMID: 26727530)
Alcohol Clin Exp Res. 2005 Nov;29(11):2053-62. (PMID: 16340464)
Front Cell Neurosci. 2015 Jan 12;8:450. (PMID: 25628535)
Can J Exp Psychol. 2007 Dec;61(4):328-44. (PMID: 18266509)
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9858-63. (PMID: 17535929)
J Vis Exp. 2016 Nov 3;(117):. (PMID: 27842358)
Alcohol Clin Exp Res. 2012 Mar;36(3):457-66. (PMID: 21933200)
J Chem Neuroanat. 2019 Dec;102:101686. (PMID: 31562917)
Alcohol Clin Exp Res. 2002 Nov;26(11):1752-8. (PMID: 12436066)
Exp Brain Res. 2005 Aug;165(2):167-78. (PMID: 15856205)
Neuroscience. 2009 Jun 30;161(2):427-40. (PMID: 19348874)
Curr Protoc Neurosci. 2001 Aug;Chapter 8:Unit 8.12. (PMID: 18428540)
Metab Brain Dis. 2016 Feb;31(1):93-107. (PMID: 26088184)
J Comp Neurol. 1995 Nov 13;362(2):283-92. (PMID: 8576439)
فهرسة مساهمة: Keywords: behavioral tests; mice; motor activity; motor coordination; prenatal alcohol exposure (PAE); pyrazole
تواريخ الأحداث: Date Created: 20230424 Latest Revision: 20230426
رمز التحديث: 20230502
مُعرف محوري في PubMed: PMC10123635
DOI: 10.3390/neurolint15020036
PMID: 37092508
قاعدة البيانات: MEDLINE
الوصف
تدمد:2035-8385
DOI:10.3390/neurolint15020036