دورية أكاديمية
أعرض في EDS

Chronic corticosterone exposure evokes itch hypersensitivity and sexual dysfunction in male rats: Relationship between the two distinct gastrin-releasing peptide systems in the spinal cord.

التفاصيل البيبلوغرافية
العنوان: Chronic corticosterone exposure evokes itch hypersensitivity and sexual dysfunction in male rats: Relationship between the two distinct gastrin-releasing peptide systems in the spinal cord.
المؤلفون: Takanami K; Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi, Okayama 701-4303, Japan; Mouse Genomics Resources Laboratory, National Institute of Genetics, Yata, Mishima, Shizuoka 411-8540, Japan; Department of Environmental Health, Faculty of Human Life and Environmental Sciences, Nara Women's University, Kitauoya Nishimachi, Nara 630-8506, Japan. Electronic address: takanami@cc.nara-wu.ac.jp., Morishita M; Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi, Okayama 701-4303, Japan., Sakamoto T; Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi, Okayama 701-4303, Japan., Sakamoto H; Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi, Okayama 701-4303, Japan.
المصدر: General and comparative endocrinology [Gen Comp Endocrinol] 2023 Aug 01; Vol. 339, pp. 114289. Date of Electronic Publication: 2023 Apr 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0370735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6840 (Electronic) Linking ISSN: 00166480 NLM ISO Abbreviation: Gen Comp Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Academic Press
Original Publication: New York.
مواضيع طبية MeSH: Corticosterone*/metabolism , Pruritus*/metabolism, Humans ; Rats ; Male ; Animals ; Gastrin-Releasing Peptide/genetics ; Gastrin-Releasing Peptide/metabolism ; Spinal Cord ; RNA, Messenger/metabolism
مستخلص: In today's society, people are subjected to many social stressors, and excessive chronic stress causes functional disruption of the neuroendocrine system and many diseases. Although the exacerbation of atopic dermatitis with symptoms of itching and erectile dysfunction is induced by chronic stress, the details of the mechanisms are unknown. Here, we examined the effects of chronic stress on itch sensation and male sexual function at the behavioral and molecular levels, focusing on two distinct gastrin-releasing peptide (GRP) systems that independently regulate itch transmission, i.e., the somatosensory GRP system, and male sexual function, i.e., the lumbosacral autonomic GRP system, in the spinal cord. In a rat model of chronic stress induced by chronic corticosterone (CORT) administration, we observed increased plasma CORT concentrations, decreased body weight, and increased anxiety-like behavior, similar to that observed in humans. Chronic CORT exposure induced hypersensitivity to itch and increased the Grp mRNA level in the spinal somatosensory system, but there was no change in pain or tactile sensitivity. Antagonists of the somatosensory GRP receptor, an itch-specific mediator, suppressed itch hypersensitivity induced by chronic CORT exposure. In contrast, chronic CORT exposure decreased male sexual behavior, ejaculated semen volume, vesicular gland weight, and plasma testosterone levels. However, there were no effects on the expression of Grp mRNA or protein in the lumbosacral autonomic GRP system, which regulates male sexual function. In summary, chronic stress model rats showed itch hypersensitivity and impaired sexual function in males, and the involvement of the spinal GRP systems was apparent in itch hypersensitivity.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Chronic stress; Corticosterone treatment; Gastrin-releasing peptide; Gastrin-releasing peptide receptor; Itch; Male sexual function; Spinal cord
المشرفين على المادة: 80043-53-4 (Gastrin-Releasing Peptide)
W980KJ009P (Corticosterone)
0 (RNA, Messenger)
تواريخ الأحداث: Date Created: 20230424 Date Completed: 20230605 Latest Revision: 20230607
رمز التحديث: 20230608
DOI: 10.1016/j.ygcen.2023.114289
PMID: 37094615
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-6840
DOI:10.1016/j.ygcen.2023.114289