دورية أكاديمية
Feasibility of clinical studies of chemical exchange saturation transfer magnetic resonance imaging of prostate cancer at 7 T.
| العنوان: | Feasibility of clinical studies of chemical exchange saturation transfer magnetic resonance imaging of prostate cancer at 7 T. |
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| المؤلفون: | Reesink DJ; Department of Oncological Urology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Arteaga de Castro CS; Department of Precision Imaging, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Van der Velden T; Department of Precision Imaging, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Van Vooren J; Department of Radiology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Oost P; Department of Urology, Tergooi Hospital Hilversum, Hilversum, The Netherlands., Jonges TGN; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands., Lam MGEH; Department of Radiology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., de Keizer B; Department of Radiology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Willemse PM; Department of Oncological Urology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Meijer RP; Department of Oncological Urology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Klomp DWJ; Department of Precision Imaging, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. |
| المصدر: | NMR in biomedicine [NMR Biomed] 2023 Oct; Vol. 36 (10), pp. e4958. Date of Electronic Publication: 2023 May 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8915233 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1492 (Electronic) Linking ISSN: 09523480 NLM ISO Abbreviation: NMR Biomed Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Chichester : Wiley Original Publication: London : Heyden & Son, 1988- |
| مواضيع طبية MeSH: | Creatine* , Prostatic Neoplasms*/diagnostic imaging, Male ; Humans ; Aged ; Feasibility Studies ; Magnetic Resonance Imaging/methods ; Protons ; Amides/chemistry ; Amines |
| مستخلص: | Chemical exchange saturation transfer (CEST) has been explored for differentiation between tumour and benign tissue in prostate cancer (PCa) patients. With ultrahigh field strengths such as 7-T, the increase of spectral resolution and sensitivity could allow for selective detection of amide proton transfer (APT) at 3.5 ppm and a group of compounds that resonate at 2 ppm (i.e., [poly]amines and/or creatine). The potential of 7-T multipool CEST analysis of the prostate and the detection of PCa was studied in patients with proven localised PCa who were scheduled to undergo robot-assisted radical prostatectomy (RARP). Twelve patients were prospectively included (mean age 68.0 years, mean serum prostate-specific antigen 7.8ng/mL). A total of 24 lesions larger than 2 mm were analysed. Used were 7-T T2-weighted (T2W) imaging and 48 spectral CEST points. Patients received 1.5-T/3-T prostate magnetic resonance imaging and galium-68-prostate-specific membrane antigen-positron emission tomography/computerised tomography to determine the location of the single-slice CEST. Based on the histopathological results after RARP, three regions of interest were drawn on the T2W images from a known malignant zone and benign zone in the central and peripheral zones. These areas were transposed to the CEST data, from which the APT and 2-ppm CEST were calculated. The statistical significance of the CEST between the central zone, the peripheral zone, and tumour was calculated using a Kruskal-Wallis test. The z-spectra showed that APT and even a distinct pool that resonated at 2 ppm were detectable. This study showed a difference trend in the APT levels, but no difference in the 2-ppm levels when tested between the central zone, the peripheral zone, and tumour (H(2) = 4.8, p = 0.093 and H(2) = 0.86, p = 0.651, respectively). Thus, to conclude, we could most likely detect APT and amines and/or creatine levels noninvasively in prostate using the CEST effect. At group level, CEST showed a higher level of APT in the peripheral versus the central zone; however, no differences of APT and 2-ppm levels were observed in tumours. (© 2023 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: 7 T; MRI; diagnostic accuracy; high field; prostate cancer |
| المشرفين على المادة: | MU72812GK0 (Creatine) 0 (Protons) 0 (Amides) 0 (Amines) |
| تواريخ الأحداث: | Date Created: 20230424 Date Completed: 20230915 Latest Revision: 20231003 |
| رمز التحديث: | 20231003 |
| DOI: | 10.1002/nbm.4958 |
| PMID: | 37094995 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-1492 |
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| DOI: | 10.1002/nbm.4958 |