دورية أكاديمية
أعرض في EDS

A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial.

التفاصيل البيبلوغرافية
العنوان: A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial.
المؤلفون: Haskey N; Department of Biology, Irving K Barber Faculty of Science, University of British Columbia-Okanagan, Kelowna, BC, Canada., Estaki M; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Ye J; Diabetes Center, University of California San Francisco, San Francisco, CA, USA., Shim RK; Department of Public Health Sciences, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Singh S; Division of Gastroenterology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Dieleman LA; Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada., Jacobson K; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition and British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Gibson DL; Department of Biology, Irving K Barber Faculty of Science, University of British Columbia-Okanagan, Kelowna, BC, Canada.; Department of Medicine, Faculty of Medicine, University of British Columbia, BC, Canada.
المصدر: Journal of Crohn's & colitis [J Crohns Colitis] 2023 Nov 08; Vol. 17 (10), pp. 1569-1578.
نوع المنشور: Randomized Controlled Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Oxford : Oxford University Press
Original Publication: Amsterdam : Elsevier Science
مواضيع طبية MeSH: Colitis, Ulcerative*/drug therapy , Diet, Mediterranean*, Adult ; Humans ; Female ; Middle Aged ; Male ; Prospective Studies ; RNA, Ribosomal, 16S ; Canada ; Inflammation ; Feces/chemistry ; Butyric Acid ; Leukocyte L1 Antigen Complex/analysis
مستخلص: Background and Aims: Dietary patterns are important in managing ulcerative colitis [UC], given their influence on gut microbiome-host symbiosis and inflammation. We investigated whether the Mediterranean Diet Pattern [MDP] vs the Canadian Habitual Diet Pattern [CHD] would affect disease activity, inflammation, and the gut microbiome in patients with quiescent UC.
Methods: We performed a prospective, randomised, controlled trial in adults [65% female; median age 47 years] with quiescent UC in an outpatient setting from 2017 to 2021. Participants were randomised to an MDP [n = 15] or CHD [n = 13] for 12 weeks. Disease activity [Simple Clinical Colitis Activity Index] and faecal calprotectin [FC] were measured at baseline and week 12. Stool samples were analysed by 16S rRNA gene amplicon sequencing.
Results: The diet was well tolerated by the MDP group. At week 12, 75% [9/12] of participants in the CHD had an FC >100 μg/g, vs 20% [3/15] of participants in the MDP group. The MDP group had higher levels of total faecal short chain fatty acids [SCFAs] [p = 0.01], acetic acid [p = 0.03], and butyric acid [p = 0.03] compared with the CHD. Furthermore, the MDP induced alterations in microbial species associated with a protective role in colitis [Alistipes finegoldii and Flavonifractor plautii], as well as the production of SCFAs [Ruminococcus bromii].
Conclusions: An MDP induces gut microbiome alterations associated with the maintenance of clinical remission and reduced FC in patients with quiescent UC. The data support that the MDP is a sustainable diet pattern that could be recommended as a maintenance diet and adjunctive therapy for UC patients in clinical remission. ClinicalTrials.gov no: NCT0305371.
(© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.)
التعليقات: Comment in: J Crohns Colitis. 2023 Jun 23;:. (PMID: 37350629)
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معلومات مُعتمدة: Canada CAPMC CIHR
فهرسة مساهمة: Keywords: Mediterranean diet; inflammation; microbiome; ulcerative colitis
المشرفين على المادة: 0 (RNA, Ribosomal, 16S)
107-92-6 (Butyric Acid)
0 (Leukocyte L1 Antigen Complex)
تواريخ الأحداث: Date Created: 20230424 Date Completed: 20231113 Latest Revision: 20231113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10637046
DOI: 10.1093/ecco-jcc/jjad073
PMID: 37095601
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-4479
DOI:10.1093/ecco-jcc/jjad073