دورية أكاديمية
Model-Based Analysis of Pathway Recruitment During Subthalamic Deep Brain Stimulation.
| العنوان: | Model-Based Analysis of Pathway Recruitment During Subthalamic Deep Brain Stimulation. |
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| المؤلفون: | Bower KL; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Noecker AM; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Frankemolle-Gilbert AM; Department of Biomedical Engineering, Duke University, Durham, NC, USA., McIntyre CC; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Neurosurgery, Duke University, Durham, NC, USA. Electronic address: cameron.mcintyre@duke.edu. |
| المصدر: | Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2024 Apr; Vol. 27 (3), pp. 455-463. Date of Electronic Publication: 2023 Apr 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9804159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1403 (Electronic) Linking ISSN: 10947159 NLM ISO Abbreviation: Neuromodulation Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [New York] : Elsevier Original Publication: Malden, MA : Blackwell Science, c1998- |
| مواضيع طبية MeSH: | Deep Brain Stimulation* , Parkinson Disease*/therapy , Subthalamic Nucleus*/physiology, Humans ; Axons ; Electrodes |
| مستخلص: | Background: Subthalamic deep brain stimulation (DBS) is an established clinical therapy, but an anatomically clear definition of the underlying neural target(s) of the stimulation remains elusive. Patient-specific models of DBS are commonly used tools in the search for stimulation targets, and recent iterations of those models are focused on characterizing the brain connections that are activated by DBS. Objective: The goal of this study was to quantify axonal pathway activation in the subthalamic region from DBS at different electrode locations and stimulation settings. Materials and Methods: We used an anatomically and electrically detailed computational model of subthalamic DBS to generate recruitment curves for eight different axonal pathways of interest, at three generalized DBS electrode locations in the subthalamic nucleus (STN) (ie, central STN, dorsal STN, posterior STN). These simulations were performed with three levels of DBS electrode localization uncertainty (ie, 0.5 mm, 1.0 mm, 1.5 mm). Results: The recruitment curves highlight the diversity of pathways that are theoretically activated with subthalamic DBS, in addition to the dependence of the stimulation location and parameter settings on the pathway activation estimates. The three generalized DBS locations exhibited distinct pathway recruitment curve profiles, suggesting that each stimulation location would have a different effect on network activity patterns. We also found that the use of anodic stimuli could help limit activation of the internal capsule relative to other pathways. However, incorporating realistic levels of DBS electrode localization uncertainty in the models substantially limits their predictive capabilities. Conclusions: Subtle differences in stimulation location and/or parameter settings can impact the collection of pathways that are activated during subthalamic DBS. Competing Interests: Conflict of Interest Cameron C. McIntyre is a paid consultant for Boston Scientific Neuromodulation, receives royalties from Hologram Consultants, Neuros Medical, and Qr8 Health, and is a shareholder in the following companies: Hologram Consultants, Surgical Information Sciences, BrainDynamics, CereGate, Autonomic Technologies, Cardionomic, and Enspire DBS. Angela M. Noecker is a paid consultant for Hologram Consultants. Kelsey L. Bower is an employee for CereGate and completed an internship with Boston Scientific. Anneke M. Frankemolle-Gilbert reported no conflict of interest. (Copyright © 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | F31 NS098696 United States NS NINDS NIH HHS; R01 NS105690 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: Axons; Parkinson’s disease; electrode; subthalamic nucleus |
| تواريخ الأحداث: | Date Created: 20230425 Date Completed: 20240405 Latest Revision: 20240405 |
| رمز التحديث: | 20240405 |
| مُعرف محوري في PubMed: | PMC10598236 |
| DOI: | 10.1016/j.neurom.2023.02.084 |
| PMID: | 37097269 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1525-1403 |
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| DOI: | 10.1016/j.neurom.2023.02.084 |