دورية أكاديمية
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A meta-analysis on the prevalence of resistance of Staphylococcus aureus to different antibiotics in Nigeria.

التفاصيل البيبلوغرافية
العنوان: A meta-analysis on the prevalence of resistance of Staphylococcus aureus to different antibiotics in Nigeria.
المؤلفون: Ezeh CK; Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria. ezechristian.kelechi@gmail.com., Eze CN; Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria., Dibua MEU; Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria., Emencheta SC; Department of Pharmaceutical Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria.
المصدر: Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2023 Apr 25; Vol. 12 (1), pp. 40. Date of Electronic Publication: 2023 Apr 25.
نوع المنشور: Meta-Analysis; Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101585411 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-2994 (Electronic) Linking ISSN: 20472994 NLM ISO Abbreviation: Antimicrob Resist Infect Control Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Methicillin-Resistant Staphylococcus aureus* , Staphylococcal Infections*/epidemiology , Staphylococcal Infections*/drug therapy, Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Staphylococcus aureus ; Vancomycin/pharmacology ; Prevalence ; Nigeria/epidemiology ; Chloramphenicol/pharmacology ; Chloramphenicol/therapeutic use ; Monobactams/pharmacology ; Monobactams/therapeutic use
مستخلص: Background: Rapid emergence of multidrug resistant Staphylococcus aureus has resulted to difficulty in treatment of infections caused by such strains. The aim of this meta-analysis study was to determine the pooled prevalence of resistance of S. aureus to different antibiotics in Nigeria.
Methods: Literature search for studies was done using Google scholar, PubMed, Science direct, and African Journal Online. The prevalence of S. aureus resistance to different antibiotics was evaluated using the meta-analysis proportion command in MedCalc software version 20.0 adopting a rand effect model. I 2 statistic and Egger test in MedCalc was used to evaluate the heterogeneity and the presence of publication bias among studies respectively.
Results: A total of 40, 682 studies were retrieved through the database search of which 98 studies met the study inclusion criteria. Prevalence of resistance of S. aureus to different antibiotics ranges from 13 to 82%. Results showed a very high degree of resistance to penicillin G (82% [95% confidence interval (CI) 61%, 0.96%]), cloxacillin (77% [95% CI 64%, 88%]), amoxacillin (74% [95% CI 66%, 81%]), cefuroxime (69% [95% CI 51%, 85%]), ampicillin (68% [95% CI 53%, 81%]). Moderately resistance to erythromycin (47% [95% CI 40%, 53%]), chloramphenicol (47% [95% CI 37%, 56%]), methicillin (46% [95% CI 37%, 56%]), ofloxacin (24% [95% CI 18%, 31%]) and rifampicin 24% [95% CI 6%, 48%]). Low resistance was observed in vancomycin 13% (95% CI 7%, 21%). For each individual meta-analysis, high heterogeneity was observed with I 2 range (79.36-98.60%) at p-values ≤ 0.01). Egger's tests for regression intercept in funnel plots indicated no evidence of publication bias.
Conclusion: This meta-analysis study established that S. aureus in Nigeria has developed resistance to commonly used antibiotics such as the beta-lactam class antibiotics, sulphonamides, tetracyclines, chloramphenicol, and vancomycin. Hence it is imperative to develop programs to promote rational use of antimicrobial agents, infection prevention and control to reduce the incidence of antimicrobial resistance.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Antibiotic resistance; Meta-analysis; Nigeria; Staphylococcus aureus
المشرفين على المادة: 0 (Anti-Bacterial Agents)
6Q205EH1VU (Vancomycin)
66974FR9Q1 (Chloramphenicol)
0 (Monobactams)
تواريخ الأحداث: Date Created: 20230425 Date Completed: 20230427 Latest Revision: 20230503
رمز التحديث: 20230503
مُعرف محوري في PubMed: PMC10127087
DOI: 10.1186/s13756-023-01243-x
PMID: 37098614
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-2994
DOI:10.1186/s13756-023-01243-x