دورية أكاديمية
Recent advances in understanding the impact of infection and inflammation on hematopoietic stem and progenitor cells.
| العنوان: | Recent advances in understanding the impact of infection and inflammation on hematopoietic stem and progenitor cells. |
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| المؤلفون: | Milsom MD; Division of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Institute of Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany., Essers MAG; Heidelberg Institute of Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany; Divison of Inflammatory Stress in Stem Cells, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: m.essers@dkfz.de. |
| المصدر: | Cells & development [Cells Dev] 2023 Jun; Vol. 174, pp. 203844. Date of Electronic Publication: 2023 Apr 24. |
| نوع المنشور: | Review; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101775611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2901 (Electronic) Linking ISSN: 26672901 NLM ISO Abbreviation: Cells Dev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2021]- |
| مواضيع طبية MeSH: | Hematopoiesis*/physiology , Hematopoietic Stem Cells*, Humans ; Cell Differentiation ; Cytokines ; Inflammation |
| مستخلص: | Just over one decade ago, it was discovered that hematopoietic stem cells (HSCs) could directly respond to inflammatory cytokines by mounting a proliferative response thought to mediate the emergency production of mature blood cells. In the intervening years, we have gained mechanistic insight into this so-called activation process and have started to learn such a response may come at a cost in terms of ultimately resulting in HSC exhaustion and hematologic dysfunction. In this review article, we report the progress we have made in understanding the interplay between infection, inflammation and HSCs during the funding period of the Collaborative Research Center 873 "Maintenance and Differentiation of Stem Cells in Development and Disease", and place this work within the context of recent output by others working within this field. Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aging; Clonal hematopoiesis; Hematopoietic stem cells; Infection; Inflammation |
| المشرفين على المادة: | 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20230426 Date Completed: 20230529 Latest Revision: 20230531 |
| رمز التحديث: | 20230531 |
| DOI: | 10.1016/j.cdev.2023.203844 |
| PMID: | 37100116 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2667-2901 |
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| DOI: | 10.1016/j.cdev.2023.203844 |