دورية أكاديمية
أعرض في EDS

Assessing the sensitivity and specificity of phosphatidylethanol (PEth) cutoffs to identify alcohol exposed pregnancies.

التفاصيل البيبلوغرافية
العنوان: Assessing the sensitivity and specificity of phosphatidylethanol (PEth) cutoffs to identify alcohol exposed pregnancies.
المؤلفون: Hasken JM; University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, NC, United States., Marais AS; Stellenbosch University, Department of Psychiatry, Faculty of Medicine and Health Sciences, Tygerberg, South Africa., de Vries MM; Stellenbosch University, Department of Psychiatry, Faculty of Medicine and Health Sciences, Tygerberg, South Africa., Kalberg WO; Center on Alcohol, Substance Abuse, and Addictions, University of New Mexico, Albuquerque, NM, United States., Buckley D; Center on Alcohol, Substance Abuse, and Addictions, University of New Mexico, Albuquerque, NM, United States., Parry CDH; Stellenbosch University, Department of Psychiatry, Faculty of Medicine and Health Sciences, Tygerberg, South Africa.; Alcohol, Tobacco, and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa., Seedat S; Stellenbosch University, Department of Psychiatry, Faculty of Medicine and Health Sciences, Tygerberg, South Africa., May PA; University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, NC, United States.; Stellenbosch University, Department of Psychiatry, Faculty of Medicine and Health Sciences, Tygerberg, South Africa.; Center on Alcohol, Substance Abuse, and Addictions, University of New Mexico, Albuquerque, NM, United States.
المصدر: Current research in toxicology [Curr Res Toxicol] 2023 Apr 05; Vol. 4, pp. 100105. Date of Electronic Publication: 2023 Apr 05 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101771915 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-027X (Electronic) Linking ISSN: 2666027X NLM ISO Abbreviation: Curr Res Toxicol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2020]-
مستخلص: In the literature on alcohol use biomarkers, there has been debate as to what a valid and/or utilitarian cut off level should be for various research applications. In this manuscript, we assessed the sensitivity and specificity of multiple cutoff values for phosphatidylethanol (PEth) from bloodspots relative to self-report, the Alcohol Use Disorder Identification Test (AUDIT) scores, and another alcohol use biomarker ethyl glucuronide (EtG) from fingernails in a sample of 222 pregnant women in the Western Cape Province of South Africa. Receiver operating characteristic (ROC) curves were used to assess the area under the curve (AUC) and assess PEth cutoff values of ≥2, ≥4, ≥8, ≥14, and ≥20 nanograms per milliliter (ng/ml). The highest AUC value was attained when PEth was compared to an AUDIT score of 1 or more. Depending on the cutoff used to determine alcohol consumption, PEth identified 47%-70% of the individuals as alcohol-consuming while 62.6%-75.2% were identified by self-reported measures, and 35.6% were identified by EtG. In this sample, sensitivity and accuracy were highest at less stringent PEth cutoffs when compared to self-report, AUDIT score of 1 or more, 5 or more, 8 or more, and EtG ≥ 8 picograms per milligram (pg/mg). For research purposes, less stringent cutoffs, such as PEth ≥ 8 ng/ml, may be considered a valid, positive cutoff for identifying women who consume alcohol during pregnancy in this population. A cutoff of PEth ≥ 20 ng/ml may miss individuals who reported consuming alcohol (false negatives).
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Author(s).)
References: Addict Biol. 2010 Jan;15(1):88-95. (PMID: 20002024)
Pediatrics. 2016 Aug;138(2):. (PMID: 27464676)
Drug Alcohol Depend. 2017 Sep 1;178:80-86. (PMID: 28645063)
Alcohol Clin Exp Res. 2016 Aug;40(8):1779-87. (PMID: 27426424)
Pediatrics. 2002 May;109(5):815-25. (PMID: 11986441)
J Stud Alcohol. 1990 Jan;51(1):68-76. (PMID: 2299853)
Alcohol Clin Exp Res. 2020 Nov;44(11):2177-2186. (PMID: 32981101)
J Forensic Sci. 2018 Nov;63(6):1634-1640. (PMID: 30005144)
Drug Test Anal. 2011 Apr;3(4):195-200. (PMID: 21438164)
Alcohol Alcohol. 1998 Jul-Aug;33(4):424-30. (PMID: 9719403)
Int J Mol Sci. 2016 Mar 22;17(3):417. (PMID: 27011168)
Alcohol Clin Exp Res. 2017 Apr;41(4):857-862. (PMID: 28196282)
Alcohol Clin Exp Res. 2018 May;42(5):851-860. (PMID: 29505133)
BMC Pregnancy Childbirth. 2014 Apr 03;14:127. (PMID: 24708684)
Int J Legal Med. 2017 Jan;131(1):153-160. (PMID: 27596747)
Alcohol Clin Exp Res. 1988 Aug;12(4):506-11. (PMID: 3056071)
Adv Prev Med. 2014;2014:871427. (PMID: 24639899)
CMAJ. 2016 Feb 16;188(3):191-197. (PMID: 26668194)
Reprod Toxicol. 2018 Apr;77:25-32. (PMID: 29425712)
Alcohol Clin Exp Res. 2017 May;41(5):1004-1011. (PMID: 28294365)
Soc Sci Med. 2018 Oct;215:98-106. (PMID: 30219750)
Alcohol Clin Exp Res. 2012 Mar;36(3):417-24. (PMID: 22168178)
Ther Drug Monit. 2008 Apr;30(2):249-54. (PMID: 18367990)
Alcohol Clin Exp Res. 2009 Jun;33(6):970-6. (PMID: 19302090)
Afr J Psychiatry (Johannesbg). 2012 Sep;15(5):346-51. (PMID: 23044889)
Arch Dis Child. 2023 Jan;108(1):36-41. (PMID: 36288922)
Am J Obstet Gynecol. 2008 Apr;198(4):407.e1-5. (PMID: 18221928)
Eur J Obstet Gynecol Reprod Biol. 2017 Jun;213:45-52. (PMID: 28426943)
Addiction. 2014 Mar;109(3):425-31. (PMID: 24524319)
Int J Legal Med. 2016 Nov;130(6):1527-1533. (PMID: 27255372)
Alcohol Alcohol. 2019 May 1;54(3):251-257. (PMID: 30968936)
Ther Drug Monit. 2008 Apr;30(2):239-45. (PMID: 18367988)
Drug Test Anal. 2020 Aug;12(8):1102-1108. (PMID: 32309913)
Neurotoxicol Teratol. 2017 Nov;64:73-78. (PMID: 29079497)
J Anal Toxicol. 2023 Jan 24;46(9):e232-e238. (PMID: 36107736)
Alcohol Alcohol. 2009 Sep-Oct;44(5):464-7. (PMID: 19535495)
Alcohol. 2010 Nov-Dec;44(7-8):583-94. (PMID: 20036487)
BMJ. 2006 Mar 4;332(7540):511-7. (PMID: 16488896)
Alcohol Clin Exp Res. 2020 Jun;44(6):1292-1299. (PMID: 32441809)
J Anal Toxicol. 2021 Nov 9;45(9):950-956. (PMID: 33024993)
Alcohol Alcohol. 2001 May-Jun;36(3):243-8. (PMID: 11373262)
Alcohol Clin Exp Res. 2014 Apr;38(4):1078-85. (PMID: 24511895)
فهرسة مساهمة: Keywords: Alcohol use; Alcohol use biomarkers; Ethyl glucuronide (EtG); Phosphatidylethanol (PEth); Pregnancy; Self-reported alcohol use
تواريخ الأحداث: Date Created: 20230427 Latest Revision: 20230428
رمز التحديث: 20230428
مُعرف محوري في PubMed: PMC10123138
DOI: 10.1016/j.crtox.2023.100105
PMID: 37102125
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-027X
DOI:10.1016/j.crtox.2023.100105