دورية أكاديمية
Prevalence of Renal Disease in Human Immunodeficiency Virus-Infected Children in Calabar, Nigeria.
| العنوان: | Prevalence of Renal Disease in Human Immunodeficiency Virus-Infected Children in Calabar, Nigeria. |
|---|---|
| المؤلفون: | Nsa EI; Department of Pediatrics, Faculty of Medicine, College of Medical Sciences, University of Calabar, Calabar, Nigeria., Uzomba CI; Department of Pediatrics, Faculty of Medicine, College of Medical Sciences, University of Calabar, Calabar, Nigeria., Etuk IS; Department of Pediatrics, Faculty of Medicine, College of Medical Sciences, University of Calabar, Calabar, Nigeria., Anah MU; Department of Pediatrics, Faculty of Medicine, College of Medical Sciences, University of Calabar, Calabar, Nigeria. |
| المصدر: | Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia [Saudi J Kidney Dis Transpl] 2022 Feb; Vol. 33 (Supplement), pp. S30-S38. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Country of Publication: Saudi Arabia NLM ID: 9436968 Publication Model: Print Cited Medium: Internet ISSN: 1319-2442 (Print) Linking ISSN: 13192442 NLM ISO Abbreviation: Saudi J Kidney Dis Transpl Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2007- : Mumbai : Medknow Original Publication: Riyadh : Saudi Center for Organ Transplantation, c1994- |
| مواضيع طبية MeSH: | HIV Infections*/complications , HIV Infections*/diagnosis , HIV Infections*/drug therapy , Kidney Diseases*/diagnosis , Kidney Diseases*/epidemiology, Child ; Humans ; Male ; Female ; HIV ; Creatinine ; Prevalence ; Nigeria/epidemiology ; Cross-Sectional Studies ; Proteinuria/epidemiology ; Albuminuria/diagnosis ; Albuminuria/epidemiology ; Albuminuria/urine ; Hospitals, Teaching ; Glomerular Filtration Rate ; Albumins |
| مستخلص: | Renal disease is increasingly being reported in human immunodeficiency virus (HIV)-infected children with or without antiretroviral drugs. This study was aimed at determining the prevalence of renal disease in HIV-infected children with or without treatment in Calabar, Nigeria. A descriptive cross-sectional study of 146 consecutive HIV-infected children seen at the pediatric HIV clinic of General Hospital Calabar and University of Calabar Teaching Hospital, aged six weeks to 15 years, was carried out from February 1 to September 30, 2015. Demographic and clinical data were obtained by interviewing parents and from medical records of each subject. Clinical examination, anthropometry (weight and height), and blood pressure were done on each child. Each child's urine was tested for persistent proteinuria using combi-10-urinalysis strips. All negative urine samples had urine albumin and urine creatinine determined using immunoturbidimetric assay and Jaffe kinetic reaction, respectively; hence, the urine albumin and urine creatinine ratio was calculated. The serum creatinine of each subject was estimated and used to calculate estimated glomerular filtration rate (eGFR) using Schwartz formula. Renal disease was defined by persistent proteinuria >+1 on dipstick or urine protein-creatinine ratio >0.2, decreased eGFR <60 mL/min/1.73 m 2 , and presence of microalbuminuria (urine albumin/creatinine ratio >30-300 mg/g). Data were analyzed using IBM SSPS Statistics version 20.0, and P ≤0.05 was statistically significant. A total of 146 children were recruited. Eighty-five (58.2%) were male and 61 (41.8%) were female giving a male:female ratio of 1:0.7. Fifty-three (36.3%) had renal disease, 48 (32.9%) had microalbuminuria, and five (3.4%) had persistent proteinuria. There was no significant association between renal disease and severe HIV disease (P >0.05), highly active antiretroviral therapy treatment (P >0.05), and duration of treatment (P >0.05). Renal disease is common in HIV-infected children with or without medication. Hence, they should be screened for renal disease at diagnosis and periodically. |
| المشرفين على المادة: | AYI8EX34EU (Creatinine) 0 (Albumins) |
| تواريخ الأحداث: | Date Created: 20230427 Date Completed: 20230428 Latest Revision: 20230428 |
| رمز التحديث: | 20240628 |
| DOI: | 10.4103/1319-2442.374380 |
| PMID: | 37102522 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1319-2442 |
|---|---|
| DOI: | 10.4103/1319-2442.374380 |