دورية أكاديمية

Therapeutic vulnerabilities of cancer stem cells and effects of natural products.

التفاصيل البيبلوغرافية
العنوان: Therapeutic vulnerabilities of cancer stem cells and effects of natural products.
المؤلفون: Reisenauer KN; Department of Biology, Baylor University, Waco, TX, USA. Joseph_Taube@baylor.edu., Aroujo J; Department of Chemistry and Biochemistry, Baylor Univesrity, Waco, TX, USA., Tao Y; Department of Chemistry and Biochemistry, Baylor Univesrity, Waco, TX, USA., Ranganathan S; Department of Biology, Baylor University, Waco, TX, USA. Joseph_Taube@baylor.edu., Romo D; Department of Chemistry and Biochemistry, Baylor Univesrity, Waco, TX, USA., Taube JH; Department of Biology, Baylor University, Waco, TX, USA. Joseph_Taube@baylor.edu.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
المصدر: Natural product reports [Nat Prod Rep] 2023 Aug 16; Vol. 40 (8), pp. 1432-1456. Date of Electronic Publication: 2023 Aug 16.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 8502408 Publication Model: Electronic Cited Medium: Internet ISSN: 1460-4752 (Electronic) Linking ISSN: 02650568 NLM ISO Abbreviation: Nat Prod Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London, England] : Royal Society of Chemistry, c1984-
مواضيع طبية MeSH: Neoplasms*/drug therapy , Neoplasms*/pathology, Humans ; Neoplastic Stem Cells
مستخلص: Covering: 1995 to 2022Tumors possess both genetic and phenotypic heterogeneity leading to the survival of subpopulations post-treatment. The term cancer stem cells (CSCs) describes a subpopulation that is resistant to many types of chemotherapy and which also possess enhanced migratory and anchorage-independent growth capabilities. These cells are enriched in residual tumor material post-treatment and can serve as the seed for future tumor re-growth, at both primary and metastatic sites. Elimination of CSCs is a key goal in enhancing cancer treatment and may be aided by application of natural products in conjunction with conventional treatments. In this review, we highlight molecular features of CSCs and discuss synthesis, structure-activity relationships, derivatization, and effects of six natural products with anti-CSC activity.
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معلومات مُعتمدة: R15 GM146188 United States GM NIGMS NIH HHS; R35 GM134910 United States GM NIGMS NIH HHS
تواريخ الأحداث: Date Created: 20230427 Date Completed: 20230817 Latest Revision: 20240817
رمز التحديث: 20240817
مُعرف محوري في PubMed: PMC10524555
DOI: 10.1039/d3np00002h
PMID: 37103550
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-4752
DOI:10.1039/d3np00002h