دورية أكاديمية
أعرض في EDS

Liquid Biopsies Poorly miRror Renal Ischemia-Reperfusion Injury.

التفاصيل البيبلوغرافية
العنوان: Liquid Biopsies Poorly miRror Renal Ischemia-Reperfusion Injury.
المؤلفون: Williams AC; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Singh V; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Liu P; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Kriegel AJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
المصدر: Non-coding RNA [Noncoding RNA] 2023 Apr 01; Vol. 9 (2). Date of Electronic Publication: 2023 Apr 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101652294 Publication Model: Electronic Cited Medium: Internet ISSN: 2311-553X (Electronic) Linking ISSN: 2311553X NLM ISO Abbreviation: Noncoding RNA Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2015]-
مستخلص: Acute kidney injury (AKI) is the rapid reduction in renal function. It is often difficult to detect at an early stage. Biofluid microRNAs (miRs) have been proposed as novel biomarkers due to their regulatory role in renal pathophysiology. The goal of this study was to determine the overlap in AKI miRNA profiles in the renal cortex, urine, and plasma samples collected from a rat model of ischemia-reperfusion (IR)-induced AKI. Bilateral renal ischemia was induced by clamping the renal pedicles for 30 min, followed by reperfusion. Urine was then collected over 24 h, followed by terminal blood and tissue collection for small RNA profiling. Differentially expressed (IR vs. sham) miRs within the urine and renal cortex sample types demonstrated a strong correlation in normalized abundance regardless of injury (IR and sham: R 2 = 0.8710 and 0.9716, respectively). Relatively few miRs were differentially expressed in multiple samples. Further, there were no differentially expressed miRs with clinically relevant sequence conservation common between renal cortex and urine samples. This project highlights the need for a comprehensive analysis of potential miR biomarkers, including analysis of pathological tissues and biofluids, with the goal of identifying the cellular origin of altered miRs. Analysis at earlier timepoints is needed to further evaluate clinical potential.
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فهرسة مساهمة: Keywords: liquid biopsy; microRNAs; renal ischemia
تواريخ الأحداث: Date Created: 20230427 Latest Revision: 20230501
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10141369
DOI: 10.3390/ncrna9020024
PMID: 37104006
قاعدة البيانات: MEDLINE
الوصف
تدمد:2311-553X
DOI:10.3390/ncrna9020024