دورية أكاديمية

Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells.

التفاصيل البيبلوغرافية
العنوان: Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells.
المؤلفون: Arroz-Madeira S; Department of Oncology, University of Lausanne, Switzerland (S.A.M., T.V.P.).; Ludwig Institute for Cancer Research Lausanne, Switzerland (S.A.M., T.V.P.)., Bekkhus T; Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden (T.B., M.H.U.)., Ulvmar MH; Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden (T.B., M.H.U.)., Petrova TV; Department of Oncology, University of Lausanne, Switzerland (S.A.M., T.V.P.).; Ludwig Institute for Cancer Research Lausanne, Switzerland (S.A.M., T.V.P.).
المصدر: Circulation research [Circ Res] 2023 Apr 28; Vol. 132 (9), pp. 1203-1225. Date of Electronic Publication: 2023 Apr 27.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Baltimore, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Md. Grune & Stratton.
مواضيع طبية MeSH: Endothelial Cells* , Lymphatic Vessels*, Humans ; Peyer's Patches ; Lymph Nodes ; Lymphocytes ; Lymphoid Tissue
مستخلص: Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and compartmentalized niches. These niches are optimized to facilitate the encounter of naive lymphocytes with antigens and antigen-presenting cells, enabling optimal generation of adaptive immune responses. Lymphatic vessels of lymphoid organs are uniquely specialized to perform a staggering variety of tasks. These include antigen presentation, directing the trafficking of immune cells but also modulating immune cell activation and providing factors for their survival. Recent studies have provided insights into the molecular basis of such specialization, opening avenues for better understanding the mechanisms of immune-vascular interactions and their applications. Such knowledge is essential for designing better treatments for human diseases given the central role of the immune system in infection, aging, tissue regeneration and repair. In addition, principles established in studies of lymphoid organ lymphatic vessel functions and organization may be applied to guide our understanding of specialization of vascular beds in other organs.
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فهرسة مساهمة: Keywords: Peyer’s patches; immune response; lymph node; lymphatic endothelial cells; lymphatic system; lymphoid tissue; spleen
تواريخ الأحداث: Date Created: 20230427 Date Completed: 20230501 Latest Revision: 20230919
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10144364
DOI: 10.1161/CIRCRESAHA.123.322136
PMID: 37104555
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4571
DOI:10.1161/CIRCRESAHA.123.322136