دورية أكاديمية
Passive heat stress induces mitochondrial adaptations in skeletal muscle.
| العنوان: | Passive heat stress induces mitochondrial adaptations in skeletal muscle. |
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| المؤلفون: | Marchant ED; Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, USA., Nelson WB; Exercise Sciences, Brigham Young University, Provo, UT, USA., Hyldahl RD; Exercise Sciences, Brigham Young University, Provo, UT, USA., Gifford JR; Exercise Sciences, Brigham Young University, Provo, UT, USA., Hancock CR; Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, USA. |
| المصدر: | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2023; Vol. 40 (1), pp. 2205066. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8508395 Publication Model: Print Cited Medium: Internet ISSN: 1464-5157 (Electronic) Linking ISSN: 02656736 NLM ISO Abbreviation: Int J Hyperthermia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London ; Philadelphia : Taylor & Francis, c1985- |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*, Humans ; Mitochondria/metabolism ; Muscle, Skeletal/physiology ; Mitochondria, Muscle/metabolism ; Heat-Shock Response |
| مستخلص: | The mitochondria are central to skeletal muscle metabolic health. Impaired mitochondrial function is associated with various muscle pathologies, including insulin resistance and muscle atrophy. As a result, continuous efforts are made to find ways to improve mitochondrial health in the context of disuse and disease. While exercise is known to cause robust improvements in mitochondrial health, not all individuals are able to exercise. This creates a need for alternate interventions which elicit some of the same benefits as exercise. Passive heating (i.e., application of heat in the absence of muscle contractions) is one potential intervention which has been shown to increase mitochondrial enzyme content and activity, and to improve mitochondrial respiration. Associated with increases in mitochondrial content and/or function, passive heating can also improve insulin sensitivity in the context of type II diabetes and preserve muscle mass in the face of limb disuse. This area of research remains in its infancy, with many questions yet to be answered about how to maximize the benefits of passive heating and elucidate the mechanisms by which heat stress affects muscle mitochondria. |
| فهرسة مساهمة: | Keywords: HSP; Heat; atrophy; chaperones; heat shock response (i.e.; hypoxia; metabolism; microenvironment; mitochondria; pH; perfusion effects; physiological effects of hyperthermia (i.e.,; redox); skeletal muscle; thermal; thermotolerance) |
| تواريخ الأحداث: | Date Created: 20230427 Date Completed: 20230501 Latest Revision: 20230510 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/02656736.2023.2205066 |
| PMID: | 37106474 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1464-5157 |
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| DOI: | 10.1080/02656736.2023.2205066 |