دورية أكاديمية
Clinical Characteristics and Outcomes among Vaccinated and Unvaccinated Patients with Cardiovascular Disease Who Were Hospitalized for COVID-19 in Brazil: Retrospective Cohort.
| العنوان: | Clinical Characteristics and Outcomes among Vaccinated and Unvaccinated Patients with Cardiovascular Disease Who Were Hospitalized for COVID-19 in Brazil: Retrospective Cohort. |
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| المؤلفون: | Sardinha DM; Programa de Pós-Graduação em Biologia Parasitária na Amazônia, Universidade do Estado do Pará and Instituto Evandro Chagas (PPGBPA/UEPA/IEC), Belém 66087-670, Pará, Brazil.; Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde, Instituto Evandro Chagas (PPGEVS/IEC), Ananindeua 67030-000, Pará, Brazil.; Laboratório de Geoprocessamento do Instituto Evandro Chagas (LABGEO/IEC), Ananindeua 67030-000, Pará, Brazil.; Seção de Bacteriologia e Micologia, Laboratório de Biologia Molecular, Instituto Evandro Chagas (SABMI/LABMOL/IEC), Ananindeua 67030-000, Pará, Brazil., Ferreira ALDS; Programa de Pós-Graduação em Biologia Parasitária na Amazônia, Universidade do Estado do Pará and Instituto Evandro Chagas (PPGBPA/UEPA/IEC), Belém 66087-670, Pará, Brazil.; Seção de Bacteriologia e Micologia, Laboratório de Biologia Molecular, Instituto Evandro Chagas (SABMI/LABMOL/IEC), Ananindeua 67030-000, Pará, Brazil., Guimarães RJPSE; Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde, Instituto Evandro Chagas (PPGEVS/IEC), Ananindeua 67030-000, Pará, Brazil.; Laboratório de Geoprocessamento do Instituto Evandro Chagas (LABGEO/IEC), Ananindeua 67030-000, Pará, Brazil., Lima KVB; Programa de Pós-Graduação em Biologia Parasitária na Amazônia, Universidade do Estado do Pará and Instituto Evandro Chagas (PPGBPA/UEPA/IEC), Belém 66087-670, Pará, Brazil.; Seção de Bacteriologia e Micologia, Laboratório de Biologia Molecular, Instituto Evandro Chagas (SABMI/LABMOL/IEC), Ananindeua 67030-000, Pará, Brazil., Lima LNGC; Programa de Pós-Graduação em Biologia Parasitária na Amazônia, Universidade do Estado do Pará and Instituto Evandro Chagas (PPGBPA/UEPA/IEC), Belém 66087-670, Pará, Brazil.; Seção de Bacteriologia e Micologia, Laboratório de Biologia Molecular, Instituto Evandro Chagas (SABMI/LABMOL/IEC), Ananindeua 67030-000, Pará, Brazil. |
| المصدر: | Vaccines [Vaccines (Basel)] 2023 Apr 18; Vol. 11 (4). Date of Electronic Publication: 2023 Apr 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG |
| مستخلص: | Introduction: COVID-19 in Brazil has already caused, and it still causes, several impacts on health, economy, and education. The risk factors for death involved those with cardiovascular diseases (CVD), which were prioritized for the vaccination of COVID-19. Objective: To investigate the clinical characteristics and outcomes between vaccinated and unvaccinated patients with cardiovascular diseases hospitalized for COVID-19 in Brazil in the year 2022. Methods: A retrospective cohort was analyzed from the year 2022, with cases being hospitalized by COVID-19 being drawn from SIVEP-GRIPE surveillance. We compared clinical characteristics, comorbidities, and outcomes between CVD carriers and non-carriers, and we also compared vaccinated with two doses vs. those that are unvaccinated in CVD carriers. We performed chi-square, odds ratio, logistic regression, and survival analysis. Results: We included, in the cohort, 112,459 hospital inpatients. An amount of 71,661 (63.72%) of the hospitalized patients had CVD. Regarding deaths, 37,888 (33.69%) died. Regarding vaccination against COVID-19, 20,855 (18.54%) people were not vaccinated with any dose among those with CVD. Death p - < 0.001 (OR 1.307-CI 1.235-1.383) and fever p - < 0.001 (OR 1.156-CI 1.098-1.218) were associated with the unvaccinated CVD carriers, and diarrhea p -0.015 (OR 1.116-CI 1.022-1.218), dyspnea p -0.022 (OR 1.074-CI 1.011-1.142), and respiratory distress p -0.021 (OR 1.070-CI 1.011-1.134) were also recorded. Those patients who possessed predictors of death, including invasive ventilation ( p - < 0.001 (OR 8.816-CI 8.313-9.350)), were admitted to the ICU p - < 0.001 (OR 1.754-CI 1.684-1.827), and some had respiratory distress p - < 0.001 (OR 1.367-CI 1.312-1.423), dyspnea p < 0.001 (OR 1.341-CI 1.284-1.400), O Conclusions: We highlight the predictors of death for those unvaccinated against COVID-19 in this research, and we evidenced the benefits of the COVID-19 vaccine in reducing deaths in hospitalized CVD patients. |
| References: | Arq Bras Cardiol. 2022 Jan;118(1):115-373. (PMID: 35195219) Heart. 2020 Dec;106(24):1898-1905. (PMID: 33060261) Cardiol J. 2021;28(3):360-368. (PMID: 33843043) MMWR Morb Mortal Wkly Rep. 2022 Apr 15;71(15):549-555. (PMID: 35421077) Aging Clin Exp Res. 2020 Sep;32(9):1869-1878. (PMID: 32734576) Int J Infect Dis. 2021 Jun;107:300-310. (PMID: 33444752) N Engl J Med. 2022 Mar 10;386(10):933-941. (PMID: 35020982) Med J Armed Forces India. 2021 Jul;77:S278-S282. (PMID: 34334894) Sci Rep. 2021 Feb 19;11(1):4263. (PMID: 33608563) Heart. 2020 Aug;106(15):1142-1147. (PMID: 32461330) PLoS One. 2021 Jul 15;16(7):e0254635. (PMID: 34264974) J Infect. 2022 Apr;84(4):e22-e24. (PMID: 35122775) Clin Infect Dis. 2021 Dec 16;73(12):2257-2264. (PMID: 33515252) Rev Bras Epidemiol. 2020 Apr 22;23:e200032. (PMID: 32321004) Am J Emerg Med. 2021 Aug;46:382-391. (PMID: 33268238) EClinicalMedicine. 2021 Aug;38:101036. (PMID: 34308302) Circ Heart Fail. 2021 Sep;14(9):e008354. (PMID: 34517720) Nat Med. 2022 Jul;28(7):1476-1485. (PMID: 35538260) Sci Rep. 2022 Nov 2;12(1):18472. (PMID: 36323818) MMWR Morb Mortal Wkly Rep. 2021 Aug 27;70(34):1156-1162. (PMID: 34437524) N Engl J Med. 2021 Sep 23;385(13):1172-1183. (PMID: 34192426) Rev Panam Salud Publica. 2020 Apr 10;44:e32. (PMID: 32284708) Eur Heart J. 2022 Mar 14;43(11):1104-1120. (PMID: 34734634) Am J Med. 2023 Feb 19;:. (PMID: 36809811) J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104949. (PMID: 32410807) Eur Respir J. 2020 Jun 11;55(6):. (PMID: 32341104) Cardiovasc Res. 2023 Feb 09;:. (PMID: 36756815) Cad Saude Publica. 2022 May 16;38(5):PT192321. (PMID: 35584432) Hum Vaccin Immunother. 2022 Dec 31;18(1):2027160. (PMID: 35113777) Arq Bras Cardiol. 2021 Mar;116(3):371-380. (PMID: 33566937) PLoS One. 2021 Mar 18;16(3):e0248580. (PMID: 33735272) Epidemiol Serv Saude. 2021 Dec 15;30(4):e2021957. (PMID: 34932771) Cad Saude Publica. 2021 Jan 11;37(1):e00344620. (PMID: 33440416) J Clin Epidemiol. 2015 Dec;68(12):1463-71. (PMID: 26112433) Eur Heart J Qual Care Clin Outcomes. 2021 Mar 15;7(2):172-180. (PMID: 33107909) Hypertens Res. 2020 Jul;43(7):729-730. (PMID: 32355222) Cardiovasc Res. 2022 Jul 27;118(10):2329-2338. (PMID: 35732274) Cad Saude Publica. 2021 Sep 22;37(9):e00056521. (PMID: 34586160) Eur Heart J. 2020 May 14;41(19):1821-1829. (PMID: 32383763) Arq Bras Cardiol. 2021 Feb;116(2):213-218. (PMID: 33656067) Cad Saude Publica. 2021 Feb 05;37(1):e00259120. (PMID: 33566992) Front Cardiovasc Med. 2020 Oct 09;7:585866. (PMID: 33195473) Clin Microbiol Infect. 2021 Nov;27(11):1652-1657. (PMID: 34245907) Int J Environ Res Public Health. 2018 Mar 12;15(3):. (PMID: 29534534) BMJ. 2022 Jun 15;377:o1431. (PMID: 35705219) PLoS One. 2020 Aug 14;15(8):e0237131. (PMID: 32797054) Nat Med. 2022 Apr;28(4):831-837. (PMID: 35045566) Lancet. 2022 Jan 1;399(10319):25-35. (PMID: 34942103) Nat Rev Cardiol. 2020 Sep;17(9):543-558. (PMID: 32690910) Curr Probl Cardiol. 2020 Aug;45(8):100617. (PMID: 32402515) Am J Emerg Med. 2021 Aug;46:204-211. (PMID: 33071085) Infection. 2022 Jun;50(3):747-752. (PMID: 34984646) |
| معلومات مُعتمدة: | 1 United States CX CSRD VA |
| فهرسة مساهمة: | Keywords: COVID-19; COVID-19 vaccine; cardiovascular disease; hospitalized; risk factors; unvaccinated |
| تواريخ الأحداث: | Date Created: 20230428 Latest Revision: 20230501 |
| رمز التحديث: | 20230501 |
| مُعرف محوري في PubMed: | PMC10146801 |
| DOI: | 10.3390/vaccines11040861 |
| PMID: | 37112773 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2076-393X |
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| DOI: | 10.3390/vaccines11040861 |