دورية أكاديمية
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents.
| العنوان: | Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents. |
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| المؤلفون: | Sahu B; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, G.T Road, Moga, Punjab 142001, India., Bhatia R; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, G.T Road, Moga, Punjab 142001, India., Kaur D; Department of Pharmacology, ISF College of Pharmacy, Ghal Kalan, G.T Road, Moga, Punjab 142001, India., Choudhary D; Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401 Punjab, India., Rawat R; School of Health Sciences & Technology, UPES University, Dehradun 248007, India., Sharma S; Department of Biotechnology, Bennett University, Greater Noida 201310, India., Kumar B; Department of Pharmaceutical Sciences, HNB Garhwal University, Chauras Campus, Srinagar, Garhwal, Uttarakhand 246174, India; Department of Chemistry, Graphic Era (Deemed to be University), Dehradun, Uttarakhand 248002, India. Electronic address: bhupinderkumar25@gmail.com. |
| المصدر: | Bioorganic chemistry [Bioorg Chem] 2023 Jul; Vol. 136, pp. 106544. Date of Electronic Publication: 2023 Apr 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| مواضيع طبية MeSH: | Monoamine Oxidase Inhibitors*/chemistry , Neuroblastoma*, Humans ; Molecular Docking Simulation ; Structure-Activity Relationship ; Antidepressive Agents/chemistry ; Monoamine Oxidase/metabolism ; Piperazine/pharmacology ; Molecular Structure |
| مستخلص: | Piperazine derivatives have been of great interest to medicinal chemists in the development of antidepressant drugs due to their distinct molecular and structural features along with their pharmacological profile. In this study, we have designed and synthesized a series of 10 compounds of piperazine clubbed oxadiazole derivatives (5a-j) and screened for their MAO inhibitory activity. Compound 5f and 5 g were found to be the most potent MAO-A inhibitors of the series with IC Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antidepressant activity; Antioxidant; Benzylpiperazine; FST and TST; MAO inhibitors; Phenylpiperazine |
| المشرفين على المادة: | 0 (Monoamine Oxidase Inhibitors) 0 (Antidepressive Agents) EC 1.4.3.4 (Monoamine Oxidase) 1RTM4PAL0V (Piperazine) |
| تواريخ الأحداث: | Date Created: 20230428 Date Completed: 20230529 Latest Revision: 20230531 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bioorg.2023.106544 |
| PMID: | 37116324 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2023.106544 |