دورية أكاديمية
A systematic review and multilevel meta-analysis of the prenatal and early life stress effects on rodent microglia, astrocyte, and oligodendrocyte density and morphology.
| العنوان: | A systematic review and multilevel meta-analysis of the prenatal and early life stress effects on rodent microglia, astrocyte, and oligodendrocyte density and morphology. |
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| المؤلفون: | Orso R; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy., Creutzberg KC; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy., Lumertz FS; School of Medicine, Developmental Cognitive Neuroscience Lab, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga 6681, Building 12A, 90619-900 Porto Alegre, Brazil., Kestering-Ferreira E; School of Medicine, Developmental Cognitive Neuroscience Lab, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga 6681, Building 12A, 90619-900 Porto Alegre, Brazil., Stocchero BA; School of Medicine, Developmental Cognitive Neuroscience Lab, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga 6681, Building 12A, 90619-900 Porto Alegre, Brazil; Psychology Program, Federal University of Health Sciences of Porto Alegre, Rua Sarmento Leite 245, 90050-170 Porto Alegre, Brazil., Perrone MK; School of Medicine, Developmental Cognitive Neuroscience Lab, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga 6681, Building 12A, 90619-900 Porto Alegre, Brazil., Begni V; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy., Grassi-Oliveira R; Translational Neuropsychiatry Unit, Aarhus University, Entrance A, Palle Juul-Jenses Blvd. 11, 6th floor, 8200 Aarhus, Denmark., Riva MA; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy; Biological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy. Electronic address: m.riva@unimi.it., Viola TW; School of Medicine, Developmental Cognitive Neuroscience Lab, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga 6681, Building 12A, 90619-900 Porto Alegre, Brazil. Electronic address: thiago.wendt@pucrs.br. |
| المصدر: | Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2023 Jul; Vol. 150, pp. 105202. Date of Electronic Publication: 2023 Apr 26. |
| نوع المنشور: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: United States NLM ID: 7806090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7528 (Electronic) Linking ISSN: 01497634 NLM ISO Abbreviation: Neurosci Biobehav Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Pergamon Press Original Publication: Fayetteville, N. Y., ANKHO International Inc. |
| مواضيع طبية MeSH: | Astrocytes* , Stress, Psychological*, Animals ; Female ; Pregnancy ; Microglia ; Oligodendroglia ; Rodentia |
| مستخلص: | Exposure to stress during early development may lead to altered neurobiological functions, thus increasing the risk for psychiatric illnesses later in life. One potential mechanism associated with those outcomes is the disruption of glial density and morphology, despite results from rodent studies have been conflicting. To address that we performed a systematic review and meta-analysis of rodent studies that investigated the effects of prenatal stress (PNS) and early life stress (ELS) on microglia, astrocyte, and oligodendrocyte density and morphology within the offspring. Our meta-analysis demonstrates that animals exposed to PNS or ELS showed significant increase in microglia density, as well as decreased oligodendrocyte density. Moreover, ELS exposure induced an increase in microglia soma size. However, we were unable to identify significant effects on astrocytes. Meta-regression indicated that experimental stress protocol, sex, age, and type of tissue analyzed are important covariates that impact those results. Importantly, PNS microglia showed higher estimates in young animals, while the ELS effects were stronger in adult animals. This set of data reinforces that alterations in glial cells could play a role in stress-induced dysfunctions throughout development. Competing Interests: Conflict of interest M.A.R. has received compensation as speaker/consultant from Angelini, Lundbeck, Otzuka and Sumitomo Pharma, and he has received research grants from Sumitomo Pharma. All the other authors declare no financial interests or potential conflicts of interest. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Astrocyte; Early life stress; Glia; Microglia; Oligodendrocyte; Prenatal stress |
| تواريخ الأحداث: | Date Created: 20230428 Date Completed: 20230613 Latest Revision: 20230613 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.neubiorev.2023.105202 |
| PMID: | 37116770 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-7528 |
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| DOI: | 10.1016/j.neubiorev.2023.105202 |