دورية أكاديمية
أعرض في EDS

Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways.

التفاصيل البيبلوغرافية
العنوان: Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways.
المؤلفون: Li C; Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China.; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China., Tao L; Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China., Guan G; Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China.; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China., Guan Z; Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China., Perry AM; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, 95343, USA.; Quantitative and Systems Biology Graduate Program, University of California, Merced, Merced, CA, 95343, USA., Hu T; Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China., Bing J; Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China., Xu M; Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China., Nobile CJ; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California, Merced, Merced, CA, 95343, USA., Huang G; Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China. huanggh@fudan.edu.cn.; Shanghai Engineering Research Center of Industrial Microorganisms, Shanghai, 200438, China. huanggh@fudan.edu.cn.; Shanghai Huashen Institute of Microbes and Infections, Shanghai, 200052, China. huanggh@fudan.edu.cn.
المصدر: Science China. Life sciences [Sci China Life Sci] 2023 Aug; Vol. 66 (8), pp. 1915-1929. Date of Electronic Publication: 2023 Apr 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Beijing : Science China Press, co-published with Springer
مواضيع طبية MeSH: Candida albicans*/genetics , Fungal Proteins*/genetics , Fungal Proteins*/metabolism, Humans ; Trehalose/metabolism ; Humidity ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology ; Reproduction/physiology
مستخلص: Sexual reproduction is prevalent in eukaryotic organisms and plays a critical role in the evolution of new traits and in the generation of genetic diversity. Environmental factors often have a direct impact on the occurrence and frequency of sexual reproduction in fungi. The regulatory effects of atmospheric relative humidity (RH) on sexual reproduction and pathogenesis in plant fungal pathogens and in soil fungi have been extensively investigated. However, the knowledge of how RH regulates the lifecycles of human fungal pathogens is limited. In this study, we report that low atmospheric RH promotes the development of mating projections and same-sex (homothallic) mating in the human fungal pathogen Candida albicans. Low RH causes water loss in C. albicans cells, which results in osmotic stress and the generation of intracellular reactive oxygen species (ROS) and trehalose. The water transporting aquaporin Aqy1, and the G-protein coupled receptor Gpr1 function as cell surface sensors of changes in atmospheric humidity. Perturbation of the trehalose metabolic pathway by inactivating trehalose synthase or trehalase promotes same-sex mating in C. albicans by increasing osmotic or ROS stresses, respectively. Intracellular trehalose and ROS signal the Hog1-osmotic and Hsf1-Hsp90 signaling pathways to regulate the mating response. We, therefore, propose that the cell surface sensors Aqy1 and Gpr1, intracellular trehalose and ROS, and the Hog1-osmotic and Hsf1-Hsp90 signaling pathways function coordinately to regulate sexual mating in response to low atmospheric RH conditions in C. albicans.
(© 2023. Science China Press.)
References: Elife. 2016 Apr 19;5:. (PMID: 27090086)
J Fungi (Basel). 2021 Feb 12;7(2):. (PMID: 33673296)
Curr Biol. 2009 Feb 24;19(4):330-4. (PMID: 19200725)
Genetics. 2019 Jan;211(1):277-288. (PMID: 30463870)
Antimicrob Agents Chemother. 2017 Jul 25;61(8):. (PMID: 28507115)
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14970-5. (PMID: 14645702)
Microbiol Spectr. 2017 Jun;5(3):. (PMID: 28597825)
PLoS One. 2014 Apr 15;9(4):e94049. (PMID: 24736409)
PLoS Biol. 2019 Mar 13;17(3):e2006966. (PMID: 30865631)
Mol Biol Cell. 2006 Feb;17(2):1018-32. (PMID: 16339080)
Plant Dis. 2005 Jun;89(6):624-630. (PMID: 30795388)
Protein Sci. 2009 Jan;18(1):24-36. (PMID: 19177348)
Emerg Infect Dis. 2007 May;13(5):747-50. (PMID: 17553256)
Curr Biol. 2012 Aug 21;22(16):R620-2. (PMID: 22917504)
PLoS Genet. 2014 Oct 16;10(10):e1004737. (PMID: 25329547)
Anal Biochem. 1995 Jun 10;228(1):143-9. (PMID: 8572270)
Curr Biol. 2018 May 21;28(10):R619-R634. (PMID: 29787730)
Appl Environ Microbiol. 2015 Oct 16;82(1):184-91. (PMID: 26475114)
FEMS Microbiol Rev. 2000 Oct;24(4):469-86. (PMID: 10978547)
Biol Cell. 2010 Jan;103(1):35-54. (PMID: 21143194)
Biochim Biophys Acta. 1993 Mar 21;1156(3):263-6. (PMID: 8461315)
Mol Cell. 1998 Apr;1(5):639-48. (PMID: 9660948)
Mikrobiologiia. 2014 May-Jun;83(3):271-83. (PMID: 25844437)
Arch Microbiol. 2000 Oct;174(4):217-24. (PMID: 11081789)
Glycobiology. 2003 Apr;13(4):17R-27R. (PMID: 12626396)
Antonie Van Leeuwenhoek. 1990 Oct;58(3):209-17. (PMID: 2256682)
Front Microbiol. 2018 Mar 21;9:503. (PMID: 29619017)
J Bacteriol. 1987 Jan;169(1):189-97. (PMID: 3539914)
PLoS Pathog. 2021 Mar 31;17(3):e1009138. (PMID: 33788904)
Diagn Microbiol Infect Dis. 2004 Jan;48(1):33-7. (PMID: 14761719)
PLoS Genet. 2012;8(3):e1002562. (PMID: 22438817)
Mol Biol Cell. 2009 Jul;20(14):3178-91. (PMID: 19458191)
Clin Microbiol Infect. 2014 Jun;20 Suppl 6:5-10. (PMID: 24506442)
Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12813-8. (PMID: 16905649)
Proc Natl Acad Sci U S A. 2015 May 12;112(19):6122-7. (PMID: 25918381)
Trends Genet. 2012 May;28(5):197-203. (PMID: 22364928)
Mol Biol Cell. 2009 Nov;20(22):4845-55. (PMID: 19759180)
Genetics. 2017 Nov;207(3):1195-1211. (PMID: 28912344)
J Bacteriol. 1987 Dec;169(12):5579-88. (PMID: 3316187)
J Bacteriol. 1980 Sep;143(3):1384-94. (PMID: 6997270)
Nature. 2009 Aug 13;460(7257):890-3. (PMID: 19675652)
PLoS Genet. 2016 Jun 24;12(6):e1006142. (PMID: 27341673)
Plant Dis. 2010 Dec;94(12):1417-1424. (PMID: 30743380)
Clin Infect Dis. 2013 May;56(9):1273-9. (PMID: 23386634)
J Infect Dis. 2020 Mar 16;221(Suppl 2):S139-S147. (PMID: 32176789)
Appl Environ Microbiol. 1984 Feb;47(2):390-4. (PMID: 6538774)
J Clin Med. 2022 Jan 24;11(3):. (PMID: 35160026)
mBio. 2011 Jul 26;2(4):. (PMID: 21791579)
mBio. 2016 Apr 26;7(2):e00465-16. (PMID: 27118591)
Mycoses. 2021 Aug;64(8):890-908. (PMID: 33665915)
Eukaryot Cell. 2005 Feb;4(2):298-309. (PMID: 15701792)
Annu Rev Genet. 2011;45:405-30. (PMID: 21942368)
Clin Microbiol Infect. 2004 Mar;10 Suppl 1:11-23. (PMID: 14748799)
Cell. 2002 Aug 9;110(3):293-302. (PMID: 12176317)
J Bacteriol. 1998 Aug;180(15):3809-15. (PMID: 9683476)
Graefes Arch Clin Exp Ophthalmol. 2020 Aug;258(8):1745-1755. (PMID: 32358645)
FEMS Yeast Res. 2019 May 1;19(3):. (PMID: 31076749)
Science. 1998 Sep 25;281(5385):1986-90. (PMID: 9748151)
Fungal Biol. 2019 Oct;123(10):763-772. (PMID: 31542193)
J Biol Chem. 2012 Oct 26;287(44):36873-82. (PMID: 22952228)
Gene. 2004 Oct 27;341:119-27. (PMID: 15474295)
معلومات مُعتمدة: R35 GM124594 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Candida albicans; atmospheric relative humidity; osmotic stress; same-sex mating; sexual reproduction; trehalose metabolism
المشرفين على المادة: 0 (Fungal Proteins)
B8WCK70T7I (Trehalose)
0 (Reactive Oxygen Species)
تواريخ الأحداث: Date Created: 20230428 Date Completed: 20230817 Latest Revision: 20231110
رمز التحديث: 20231110
مُعرف محوري في PubMed: PMC10631464
DOI: 10.1007/s11427-023-2309-1
PMID: 37118508
قاعدة البيانات: MEDLINE
الوصف
تدمد:1869-1889
DOI:10.1007/s11427-023-2309-1