تقرير
Concurrent chronic lymphocytic leukemia and primary hyperparathyroidism in a mule.
| العنوان: | Concurrent chronic lymphocytic leukemia and primary hyperparathyroidism in a mule. |
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| المؤلفون: | Townsend KS; Department of Veterinary Medicine and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA., Johnson PJ; Department of Veterinary Medicine and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA., Donnelly LL; Department of Veterinary Medicine and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA., LaCarrubba AM; Department of Veterinary Medicine and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA., Lattimer JC; Department of Veterinary Medicine and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA., Havis B; Department of Veterinary Medicine and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA., Springer NL; Department of Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, Tennessee, USA., Kim DY; Department of Veterinary Medicine and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA. |
| المصدر: | Journal of veterinary internal medicine [J Vet Intern Med] 2023 May-Jun; Vol. 37 (3), pp. 1250-1255. Date of Electronic Publication: 2023 Apr 28. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Periodicals Country of Publication: United States NLM ID: 8708660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-1676 (Electronic) Linking ISSN: 08916640 NLM ISO Abbreviation: J Vet Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010-> : Malden, MA : Wiley Periodicals Original Publication: Philadelphia : J.B. Lippincott Co., [c1987- |
| مواضيع طبية MeSH: | Leukemia, Lymphocytic, Chronic, B-Cell*/complications , Leukemia, Lymphocytic, Chronic, B-Cell*/diagnosis , Leukemia, Lymphocytic, Chronic, B-Cell*/veterinary , Hypercalcemia*/diagnosis , Hypercalcemia*/veterinary , Hyperparathyroidism, Primary*/diagnosis , Hyperparathyroidism, Primary*/veterinary , Lymphocytosis*/veterinary , Horse Diseases*/diagnosis, Male ; Horses ; Animals ; Equidae |
| مستخلص: | A 26-year-old mule gelding was evaluated for chronic weight loss and decreased appetite. The mule had been losing weight and intermittently hypophagic for approximately 7 months. Laboratory analysis of whole blood and plasma identified severe total hypercalcemia, marked hypophosphatemia, markedly increased parathyroid hormone concentration, and marked lymphocytosis. A sestimibi scan intended to identify parathyroid gland tissue was nondiagnostic. Results of flow cytometry and PCR for antigen receptor rearrangement (PARR) were consistent with a B cell lymphoproliferative disorder, likely chronic lymphocytic leukemia (CLL). Although not previously described concurrently, these conditions may sometimes arise together, complicating definition of the underlying mechanism for weight loss and hypercalcemia in aged equids. (© 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.) |
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| فهرسة مساهمة: | Keywords: endocrinopathy; equine; hypercalcemia; immunohistochemistry; neoplasia |
| تواريخ الأحداث: | Date Created: 20230429 Date Completed: 20230601 Latest Revision: 20230602 |
| رمز التحديث: | 20230602 |
| مُعرف محوري في PubMed: | PMC10229365 |
| DOI: | 10.1111/jvim.16714 |
| PMID: | 37118906 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1939-1676 |
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| DOI: | 10.1111/jvim.16714 |