دورية أكاديمية
أعرض في EDS

The thalamus in psychosis spectrum disorder.

التفاصيل البيبلوغرافية
العنوان: The thalamus in psychosis spectrum disorder.
المؤلفون: Anticevic A; School of Medicine, Yale University, New Haven, CT, United States., Halassa MM; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.
المصدر: Frontiers in neuroscience [Front Neurosci] 2023 Apr 13; Vol. 17, pp. 1163600. Date of Electronic Publication: 2023 Apr 13 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Psychosis spectrum disorder (PSD) affects 1% of the world population and results in a lifetime of chronic disability, causing devastating personal and economic consequences. Developing new treatments for PSD remains a challenge, particularly those that target its core cognitive deficits. A key barrier to progress is the tenuous link between the basic neurobiological understanding of PSD and its clinical phenomenology. In this perspective, we focus on a key opportunity that combines innovations in non-invasive human neuroimaging with basic insights into thalamic regulation of functional cortical connectivity. The thalamus is an evolutionary conserved region that forms forebrain-wide functional loops critical for the transmission of external inputs as well as the construction and update of internal models. We discuss our perspective across four lines of evidence: First, we articulate how PSD symptomatology may arise from a faulty network organization at the macroscopic circuit level with the thalamus playing a central coordinating role. Second, we discuss how recent animal work has mechanistically clarified the properties of thalamic circuits relevant to regulating cortical dynamics and cognitive function more generally. Third, we present human neuroimaging evidence in support of thalamic alterations in PSD, and propose that a similar "thalamocortical dysconnectivity" seen in pharmacological imaging (under ketamine, LSD and THC) in healthy individuals may link this circuit phenotype to the common set of symptoms in idiopathic and drug-induced psychosis. Lastly, we synthesize animal and human work, and lay out a translational path for biomarker and therapeutic development.
Competing Interests: AA was a member of the technology advisory board for Neumora Therapeutics, Inc. AA was a co-founder, board member, and a scientific advisor for Manifest Technologies, Inc. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Anticevic and Halassa.)
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فهرسة مساهمة: Keywords: cognition; computation; functional connectivity; mediodorsal nucleus; pharmacology; psychosis; thalamus
تواريخ الأحداث: Date Created: 20230501 Latest Revision: 20230502
رمز التحديث: 20230502
مُعرف محوري في PubMed: PMC10133512
DOI: 10.3389/fnins.2023.1163600
PMID: 37123374
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-4548
DOI:10.3389/fnins.2023.1163600