التفاصيل البيبلوغرافية
| العنوان: |
Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal. |
| المؤلفون: |
Schaffner SF, Badiane A, Khorgade A, Ndiop M, Gomis J, Wong W, Ndiaye YD, Diedhiou Y, Thwing J, Seck MC, Early A, Sy M, Deme A, Diallo MA, Sy N, Sene A, Ndiaye T, Sow D, Dieye B, Ndiaye IM, Gaye A, Ndiaye A, Battle KE, Proctor JL, Bever C, Fall FB, Diallo I, Gaye S, Sene D, Hartl DL, Wirth DF, MacInnis B, Ndiaye D, Volkman SK |
| المصدر: |
MedRxiv : the preprint server for health sciences [medRxiv] 2023 May 30. Date of Electronic Publication: 2023 May 30. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Parasite genetic surveillance has the potential to play an important role in malaria control. We describe here an analysis of data from the first year of an ongoing, nationwide program of genetic surveillance of Plasmodium falciparum parasites in Senegal, intended to provide actionable information for malaria control efforts. Looking for a good proxy for local malaria incidence, we found that the best predictor was the proportion of polygenomic infections (those with multiple genetically distinct parasites), although that relationship broke down in very low incidence settings (r = 0.77 overall). The proportion of closely related parasites in a site was more weakly correlated ( r = -0.44) with incidence while the local genetic diversity was uninformative. Study of related parasites indicated their potential for discriminating local transmission patterns: two nearby study areas had similarly high fractions of relatives, but one area was dominated by clones and the other by outcrossed relatives. Throughout the country, 58% of related parasites proved to belong to a single network of relatives, within which parasites were enriched for shared haplotypes at known and suspected drug resistance loci as well as at one novel locus, reflective of ongoing selection pressure. |
| التعليقات: |
Update in: Nat Commun. 2023 Nov 10;14(1):7268. (PMID: 37949851) |
| تواريخ الأحداث: |
Date Created: 20230503 Latest Revision: 20231120 |
| رمز التحديث: |
20240628 |
| مُعرف محوري في PubMed: |
PMC10153316 |
| DOI: |
10.1101/2023.04.11.23288401 |
| PMID: |
37131838 |
| قاعدة البيانات: |
MEDLINE |
