دورية أكاديمية
Role of Long non Coding RNAs, NEAT1 and Lnc-DC Expression in Pediatric Immune Thrombocytopenic Purpura.
العنوان: | Role of Long non Coding RNAs, NEAT1 and Lnc-DC Expression in Pediatric Immune Thrombocytopenic Purpura. |
---|---|
المؤلفون: | Hamdy SM; Departments of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt., Ali MS; Departments of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt., Abd El-Hmid RG; Departments of Pediatrics, Faculty of Medicine, Fayoum University, Egypt., Abdelghaffar NK; Departments of Clinical pathology, Faculty of Medicine, Fayoum University, Egypt., Abdelaleem OO; Departments of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Egypt. |
المصدر: | Reports of biochemistry & molecular biology [Rep Biochem Mol Biol] 2023 Jan; Vol. 11 (4), pp. 635-643. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Varastegan Institute for Medical Sciences Country of Publication: Iran NLM ID: 101637937 Publication Model: Print Cited Medium: Print ISSN: 2322-3480 (Print) Linking ISSN: 23223480 NLM ISO Abbreviation: Rep Biochem Mol Biol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Mashhad : Varastegan Institute for Medical Sciences, [2012]- |
مستخلص: | Background: Pediatric immune thrombocytopenic purpura (ITP) is an autoimmune disease; whose etiology is unknown. lncRNAs are regulators of numerous actions, which participate in the development of autoimmune diseases. We evaluated the expression ofNEAT1 and Lnc-RNA in dendritic cell (Lnc-DC) in pediatric ITP. Methods: Sixty ITP patients and 60 healthy subjects were enrolled in the present study; Real-time PCR was performed to assess the expression levels of NEAT1 and Lnc-DC in sera of children with ITP as well as healthy children. Results: Both lncRNAs, NEAT1 and Lnc-DC were significantly upregulated in ITP patients in comparison to controls (p <0.0001 and P= 0.001 respectively). Furthermore, significant upregulation of the expression levels of NEAT1 and Lnc-DC were observed in the non-chronic compared with chronic ITP patients. Also, there was significant negative correlation between each of NEAT1 and Lnc-DC and platelet counts before treatment (r= -0.38; P= 0.003 and r= -0.461; P< 0.0001, respectively). Conclusions: serum lncRNAs, NEAT1 and Lnc-DC could be used as potential biomarkers in differentiating childhood ITP patients and healthy controls in addition to differentiating non-chronic from chronic ITP which may provide a theoretical basis for the mechanism and treatment of immune thrombocytopenia. Competing Interests: None. |
References: | Front Genet. 2020 Oct 16;11:571467. (PMID: 33193674) J Autoimmun. 2016 Dec;75:96-104. (PMID: 27481557) Adv Hematol. 2017;2017:7878605. (PMID: 29362564) Rep Biochem Mol Biol. 2022 Jan;10(4):614-621. (PMID: 35291607) J Immunol Res. 2020 Oct 15;2020:9236234. (PMID: 33123604) Blood Coagul Fibrinolysis. 2016 Apr;27(3):301-7. (PMID: 26484642) Clin Chem Lab Med. 2019 Nov 26;57(12):1808-1817. (PMID: 31465290) J Cell Physiol. 2019 Dec;234(12):22477-22484. (PMID: 31119756) Sci Rep. 2021 Oct 8;11(1):20014. (PMID: 34625583) Pediatr Neonatol. 2019 Aug;60(4):411-416. (PMID: 30470618) Acta Haematol. 2013;130(4):312-8. (PMID: 24008828) J Immunol Res. 2015;2015:272359. (PMID: 26199948) Genome Res. 2009 Mar;19(3):347-59. (PMID: 19106332) Hum Immunol. 2010 Jun;71(6):586-91. (PMID: 20153790) Int J Clin Exp Pathol. 2018 May 01;11(5):2419-2429. (PMID: 31938354) Blood. 2009 Mar 12;113(11):2386-93. (PMID: 19005182) Cell Physiol Biochem. 2018;48(2):618-632. (PMID: 30021206) Cell Mol Biol Lett. 2018 Sep 03;23:43. (PMID: 30202418) Thromb Res. 2013 Aug;132(2):196-201. (PMID: 23830211) Science. 2014 Apr 18;344(6181):310-3. (PMID: 24744378) J Biomed Mater Res A. 2019 Feb;107(2):468-475. (PMID: 30478988) Korean J Intern Med. 2020 Jul;35(4):970-978. (PMID: 32264655) Nat Rev Immunol. 2011 Apr;11(4):264-74. (PMID: 21436837) Rep Biochem Mol Biol. 2020 Jul;9(2):230-240. (PMID: 33178874) Exp Hematol. 2006 Jul;34(7):879-87. (PMID: 16797415) Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Dec;21(6):1513-6. (PMID: 24370039) Clin Exp Immunol. 2014 May;176(2):291-300. (PMID: 24460857) Noncoding RNA. 2019 Jul 12;5(3):. (PMID: 31336952) Sudan J Paediatr. 2012;12(1):27-39. (PMID: 27493327) IUBMB Life. 2020 Sep;72(9):1941-1950. (PMID: 32563217) Biosci Rep. 2019 Jan 15;39(1):. (PMID: 30514825) Oncotarget. 2015 Feb 28;6(6):4505-15. (PMID: 25714016) Gastroenterol Res Pract. 2017;2017:9529752. (PMID: 28194178) |
فهرسة مساهمة: | Keywords: ITP; Lnc-DC; NEAT1; Pediatric |
تواريخ الأحداث: | Date Created: 20230503 Latest Revision: 20230508 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10149135 |
DOI: | 10.52547/rbmb.11.4.635 |
PMID: | 37131890 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2322-3480 |
---|---|
DOI: | 10.52547/rbmb.11.4.635 |