دورية أكاديمية
Role of Long non Coding RNAs, NEAT1 and Lnc-DC Expression in Pediatric Immune Thrombocytopenic Purpura.
| العنوان: | Role of Long non Coding RNAs, NEAT1 and Lnc-DC Expression in Pediatric Immune Thrombocytopenic Purpura. |
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| المؤلفون: | Hamdy SM; Departments of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt., Ali MS; Departments of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt., Abd El-Hmid RG; Departments of Pediatrics, Faculty of Medicine, Fayoum University, Egypt., Abdelghaffar NK; Departments of Clinical pathology, Faculty of Medicine, Fayoum University, Egypt., Abdelaleem OO; Departments of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Egypt. |
| المصدر: | Reports of biochemistry & molecular biology [Rep Biochem Mol Biol] 2023 Jan; Vol. 11 (4), pp. 635-643. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Varastegan Institute for Medical Sciences Country of Publication: Iran NLM ID: 101637937 Publication Model: Print Cited Medium: Print ISSN: 2322-3480 (Print) Linking ISSN: 23223480 NLM ISO Abbreviation: Rep Biochem Mol Biol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Mashhad : Varastegan Institute for Medical Sciences, [2012]- |
| مستخلص: | Background: Pediatric immune thrombocytopenic purpura (ITP) is an autoimmune disease; whose etiology is unknown. lncRNAs are regulators of numerous actions, which participate in the development of autoimmune diseases. We evaluated the expression ofNEAT1 and Lnc-RNA in dendritic cell (Lnc-DC) in pediatric ITP. Methods: Sixty ITP patients and 60 healthy subjects were enrolled in the present study; Real-time PCR was performed to assess the expression levels of NEAT1 and Lnc-DC in sera of children with ITP as well as healthy children. Results: Both lncRNAs, NEAT1 and Lnc-DC were significantly upregulated in ITP patients in comparison to controls (p <0.0001 and P= 0.001 respectively). Furthermore, significant upregulation of the expression levels of NEAT1 and Lnc-DC were observed in the non-chronic compared with chronic ITP patients. Also, there was significant negative correlation between each of NEAT1 and Lnc-DC and platelet counts before treatment (r= -0.38; P= 0.003 and r= -0.461; P< 0.0001, respectively). Conclusions: serum lncRNAs, NEAT1 and Lnc-DC could be used as potential biomarkers in differentiating childhood ITP patients and healthy controls in addition to differentiating non-chronic from chronic ITP which may provide a theoretical basis for the mechanism and treatment of immune thrombocytopenia. Competing Interests: None. |
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| فهرسة مساهمة: | Keywords: ITP; Lnc-DC; NEAT1; Pediatric |
| تواريخ الأحداث: | Date Created: 20230503 Latest Revision: 20230508 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10149135 |
| DOI: | 10.52547/rbmb.11.4.635 |
| PMID: | 37131890 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2322-3480 |
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| DOI: | 10.52547/rbmb.11.4.635 |