دورية أكاديمية
OPTN/SRTR 2021 Annual Data Report: Liver.
| العنوان: | OPTN/SRTR 2021 Annual Data Report: Liver. |
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| المؤلفون: | Kwong AJ; Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA., Ebel NH; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, CA., Kim WR; Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN., Lake JR; Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN., Smith JM; Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Pediatrics, University of Washington, Seattle, WA., Schladt DP; Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN., Schnellinger EM; Organ Procurement and Transplantation Network, United Network for Organ Sharing, Richmond, VA., Handarova D; Organ Procurement and Transplantation Network, United Network for Organ Sharing, Richmond, VA., Weiss S; Organ Procurement and Transplantation Network, United Network for Organ Sharing, Richmond, VA., Cafarella M; Organ Procurement and Transplantation Network, United Network for Organ Sharing, Richmond, VA., Snyder JJ; Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN; Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN., Israni AK; Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN; Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN., Kasiske BL; Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN. |
| المصدر: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2023 Feb; Vol. 23 (2 Suppl 1), pp. S178-S263. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Original Publication: Copenhagen : Munksgaard International Publishers, 2001- |
| مواضيع طبية MeSH: | Liver Transplantation* , Tissue and Organ Procurement* , COVID-19*/epidemiology , Liver Diseases, Alcoholic* , Liver Neoplasms*, Adult ; Child ; Humans ; United States/epidemiology ; Living Donors ; Pandemics ; Graft Survival ; Tissue Donors ; Waiting Lists |
| مستخلص: | In 2021, liver transplant volume continued to grow, with a record 9,234 transplants performed in the United States, 8,665 (93.8%) from deceased donors and 569 (6.2%) from living donors. There were 8,733 (94.6%) adult and 501 (5.4%) pediatric liver transplant recipients. An increase in the number of deceased donor livers corresponded to an increase in the overall transplant rate and shorter waiting times, although still 10.0% of livers that were recovered were not transplanted. Alcohol-associated liver disease was the leading indication for both waitlist registration and liver transplant in adults, outpacing nonalcoholic steatohepatitis, while biliary atresia remained the leading indication for children. Related to allocation policy changes implemented in 2019, the proportion of liver transplants performed for hepatocellular carcinoma has decreased. Among adult candidates listed for liver transplant in 2020, 37.7% received a deceased donor liver transplant within 3 months, 43.8% within 6 months, and 53.3% within 1 year. Pretransplant mortality improved for children following implementation of acuity circle-based distribution. Short-term graft and patient survival outcomes up to 1 year worsened for adult deceased and living donor liver transplant recipients, which is a reversal of previous trends and coincided with the onset of the COVID-19 pandemic in early 2020. Longer-term outcomes among adult deceased donor liver transplant recipients were unaffected, with overall posttransplant mortality rates of 13.3% at 3 years, 18.6% at 5 years, and 35.9% at 10 years. Pretransplant mortality improved for children following implementation of acuity circle-based distribution and prioritization of pediatric donors to pediatric recipients in 2020. Pediatric living donor recipients had superior graft and patient survival outcomes compared with deceased donor recipients at all time points. (Copyright © 2023. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: Liver transplant; allocation; distribution; waiting list |
| تواريخ الأحداث: | Date Created: 20230503 Date Completed: 20230504 Latest Revision: 20230505 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ajt.2023.02.006 |
| PMID: | 37132348 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1600-6143 |
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| DOI: | 10.1016/j.ajt.2023.02.006 |