دورية أكاديمية
Screening and diagnostic breast MRI: how do they impact surgical treatment? Insights from the MIPA study.
| العنوان: | Screening and diagnostic breast MRI: how do they impact surgical treatment? Insights from the MIPA study. |
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| المؤلفون: | Cozzi A; Unit of Radiology, IRCCS Policlinico San Donato, Via Rodolfo Morandi 30, 20097, San Donato Milanese, Italy., Di Leo G; Unit of Radiology, IRCCS Policlinico San Donato, Via Rodolfo Morandi 30, 20097, San Donato Milanese, Italy., Houssami N; The Daffodil Centre, Faculty of Medicine and Health, The University of Sydney (Joint Venture with Cancer Council NSW), Sydney, Australia., Gilbert FJ; Department of Radiology, School of Clinical Medicine, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Helbich TH; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Structural Preclinical Imaging, Medical University of Vienna, Vienna, Austria., Álvarez Benito M; Department of Radiology, Hospital Universitario Reina Sofía, Córdoba, Spain., Balleyguier C; Department of Radiology, Institut Gustave Roussy, Villejuif, France.; BioMaps (UMR1281), INSERM, CEA, CNRS, Université Paris-Saclay, Villejuif, France., Bazzocchi M; Institute of Radiology, Department of Medicine, Ospedale Universitario S. Maria della Misericordia, Università degli Studi di Udine, Udine, Italy., Bult P; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Calabrese M; Unit of Oncological and Breast Radiology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Camps Herrero J; Department of Radiology, Hospital Universitario de La Ribera, Alzira, Spain., Cartia F; Unit of Breast Imaging, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Cassano E; Breast Imaging Division, IEO, European Institute of Oncology IRCCS, Milan, Italy., Clauser P; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Structural Preclinical Imaging, Medical University of Vienna, Vienna, Austria., de Lima Docema MF; Department of Radiology, Hospital Sírio Libanês, São Paulo, Brazil., Depretto C; Unit of Breast Imaging, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Dominelli V; Breast Imaging Division, IEO, European Institute of Oncology IRCCS, Milan, Italy., Forrai G; Department of Radiology, MHEK Teaching Hospital, Semmelweis University, Budapest, Hungary., Girometti R; Institute of Radiology, Department of Medicine, Ospedale Universitario S. Maria della Misericordia, Università degli Studi di Udine, Udine, Italy., Harms SE; Breast Center of Northwest Arkansas, Fayetteville, AR, USA., Hilborne S; Department of Radiology, School of Clinical Medicine, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Ienzi R; Department of Radiology, Di.Bi.MED, Policlinico Universitario Paolo Giaccone, Università degli Studi di Palermo, Palermo, Italy., Lobbes MBI; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands., Losio C; Department of Breast Radiology, IRCCS Ospedale San Raffaele, Milan, Italy., Mann RM; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Montemezzi S; Department of Radiology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy., Obdeijn IM; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Ozcan UA; Unit of Radiology, Acıbadem Mehmet Ali Aydınlar University School of Medicine, İstanbul, Turkey., Pediconi F; Department of Radiological, Oncological and Pathological Sciences, Università degli Studi di Roma 'La Sapienza', Rome, Italy., Pinker K; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Structural Preclinical Imaging, Medical University of Vienna, Vienna, Austria.; Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Preibsch H; Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany., Raya Povedano JL; Department of Radiology, Hospital Universitario Reina Sofía, Córdoba, Spain., Rossi Saccarelli C; Department of Radiology, Hospital Sírio Libanês, São Paulo, Brazil., Sacchetto D; Kiwifarm S.r.l, La Morra, Italy.; Disaster Medicine Service 118, ASL CN1, Saluzzo, Italy.; CRIMEDIM, Research Center in Emergency and Disaster Medicine, Università degli Studi del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Scaperrotta GP; Unit of Breast Imaging, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Schlooz M; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., Szabó BK; Department of Radiology, Barking Havering and Redbridge University Hospitals NHS Trust, London, UK., Taylor DB; Medical School, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Australia.; Department of Radiology, Royal Perth Hospital, Perth, Australia., Ulus ÖS; Unit of Radiology, Acıbadem Mehmet Ali Aydınlar University School of Medicine, İstanbul, Turkey., Van Goethem M; Gynecological Oncology Unit, Department of Obstetrics and Gynecology, Department of Radiology, Multidisciplinary Breast Clinic, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium., Veltman J; Maatschap Radiologie Oost-Nederland, Oldenzaal, The Netherlands., Weigel S; Institute of Clinical Radiology and Reference Center for Mammography, University of Münster, Münster, Germany., Wenkel E; Department of Radiology, University Hospital of Erlangen, Erlangen, Germany., Zuiani C; Institute of Radiology, Department of Medicine, Ospedale Universitario S. Maria della Misericordia, Università degli Studi di Udine, Udine, Italy., Sardanelli F; Unit of Radiology, IRCCS Policlinico San Donato, Via Rodolfo Morandi 30, 20097, San Donato Milanese, Italy. francesco.sardanelli@unimi.it.; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy. francesco.sardanelli@unimi.it. |
| المصدر: | European radiology [Eur Radiol] 2023 Sep; Vol. 33 (9), pp. 6213-6225. Date of Electronic Publication: 2023 May 03. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1991- |
| مواضيع طبية MeSH: | Breast Neoplasms*/diagnostic imaging , Breast Neoplasms*/surgery, Female ; Humans ; Mastectomy ; Mastectomy, Segmental ; Breast ; Magnetic Resonance Imaging ; Preoperative Care |
| مستخلص: | Objectives: To report mastectomy and reoperation rates in women who had breast MRI for screening (S-MRI subgroup) or diagnostic (D-MRI subgroup) purposes, using multivariable analysis for investigating the role of MRI referral/nonreferral and other covariates in driving surgical outcomes. Methods: The MIPA observational study enrolled women aged 18-80 years with newly diagnosed breast cancer destined to have surgery as the primary treatment, in 27 centres worldwide. Mastectomy and reoperation rates were compared using non-parametric tests and multivariable analysis. Results: A total of 5828 patients entered analysis, 2763 (47.4%) did not undergo MRI (noMRI subgroup) and 3065 underwent MRI (52.6%); of the latter, 2441/3065 (79.7%) underwent MRI with preoperative intent (P-MRI subgroup), 510/3065 (16.6%) D-MRI, and 114/3065 S-MRI (3.7%). The reoperation rate was 10.5% for S-MRI, 8.2% for D-MRI, and 8.5% for P-MRI, while it was 11.7% for noMRI (p ≤ 0.023 for comparisons with D-MRI and P-MRI). The overall mastectomy rate (first-line mastectomy plus conversions from conserving surgery to mastectomy) was 39.5% for S-MRI, 36.2% for P-MRI, 24.1% for D-MRI, and 18.0% for noMRI. At multivariable analysis, using noMRI as reference, the odds ratios for overall mastectomy were 2.4 (p < 0.001) for S-MRI, 1.0 (p = 0.957) for D-MRI, and 1.9 (p < 0.001) for P-MRI. Conclusions: Patients from the D-MRI subgroup had the lowest overall mastectomy rate (24.1%) among MRI subgroups and the lowest reoperation rate (8.2%) together with P-MRI (8.5%). This analysis offers an insight into how the initial indication for MRI affects the subsequent surgical treatment of breast cancer. Key Points: • Of 3065 breast MRI examinations, 79.7% were performed with preoperative intent (P-MRI), 16.6% were diagnostic (D-MRI), and 3.7% were screening (S-MRI) examinations. • The D-MRI subgroup had the lowest mastectomy rate (24.1%) among MRI subgroups and the lowest reoperation rate (8.2%) together with P-MRI (8.5%). • The S-MRI subgroup had the highest mastectomy rate (39.5%) which aligns with higher-than-average risk in this subgroup, with a reoperation rate (10.5%) not significantly different to that of all other subgroups. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | P30 CA008748 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Breast neoplasms; Breast-conserving surgery; Magnetic resonance imaging; Mastectomy; Reoperation |
| تواريخ الأحداث: | Date Created: 20230503 Date Completed: 20230811 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC10415233 |
| DOI: | 10.1007/s00330-023-09600-5 |
| PMID: | 37138190 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-1084 |
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| DOI: | 10.1007/s00330-023-09600-5 |