دورية أكاديمية
A Genomic Perspective on the Near-term Impact of Doxycycline Post-exposure Prophylaxis on Neisseria gonorrhoeae Antimicrobial Resistance.
| العنوان: | A Genomic Perspective on the Near-term Impact of Doxycycline Post-exposure Prophylaxis on Neisseria gonorrhoeae Antimicrobial Resistance. |
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| المؤلفون: | Mortimer TD; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Grad YH; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Sep 11; Vol. 77 (5), pp. 788-791. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Neisseria gonorrhoeae*/genetics , Gonorrhea*/epidemiology , Gonorrhea*/prevention & control , Gonorrhea*/drug therapy, Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Doxycycline/pharmacology ; Doxycycline/therapeutic use ; Post-Exposure Prophylaxis ; Microbial Sensitivity Tests ; Drug Resistance, Bacterial/genetics ; Genomics ; Tetracycline/pharmacology |
| مستخلص: | Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for tetracycline resistance may influence prevalence of multi-drug resistant strains. Using genomic and antimicrobial susceptibility data from N. gonorrhoeae, we assessed the near-term impact of doxycycline PEP on N. gonorrhoeae resistance. Competing Interests: Potential conflicts of interest. Y. H. G. has received consulting fees from GSK and serves on the advisory board for Day Zero Diagnostics. Y. H. G. also reports grants or contracts from Wellcome Trust and Smith Family Foundation. T. D. M. reports no potential conflicts. Both authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| التعليقات: | Update of: medRxiv. 2023 Mar 17;:. (PMID: 36993406) |
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| معلومات مُعتمدة: | R01 AI132606 United States AI NIAID NIH HHS; R01 AI153521 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) N12000U13O (Doxycycline) F8VB5M810T (Tetracycline) |
| تواريخ الأحداث: | Date Created: 20230504 Date Completed: 20230913 Latest Revision: 20240505 |
| رمز التحديث: | 20240505 |
| مُعرف محوري في PubMed: | PMC10495131 |
| DOI: | 10.1093/cid/ciad279 |
| PMID: | 37138444 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciad279 |