دورية أكاديمية
أعرض في EDS

Response of terminal Schwann cells following volumetric muscle loss injury.

التفاصيل البيبلوغرافية
العنوان: Response of terminal Schwann cells following volumetric muscle loss injury.
المؤلفون: Hoffman DB; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States of America., Basten AM; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States of America., Sorensen JR; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States of America., Raymond-Pope CJ; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States of America., Lillquist TJ; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States of America., Call JA; Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, United States of America., Corona BT; School of Medicine, Wake Forest University, Winston-Salem, NC 27101, United States of America., Greising SM; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States of America. Electronic address: grei0064@umn.edu.
المصدر: Experimental neurology [Exp Neurol] 2023 Jul; Vol. 365, pp. 114431. Date of Electronic Publication: 2023 May 02.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE
أسماء مطبوعة: Publication: Orlando Fl : Academic Press
Original Publication: New York.
مواضيع طبية MeSH: Neurodegenerative Diseases*/metabolism, Rats ; Animals ; Male ; Rats, Inbred Lew ; Neuromuscular Junction/metabolism ; Schwann Cells/metabolism ; Muscle, Skeletal/metabolism
مستخلص: An often-overlooked component of traumatic skeletal muscle injuries is the impact on the nervous system and resultant innervation of the affected muscles. Recent work in a rodent model of volumetric muscle loss (VML) injury demonstrated a progressive, secondary loss of neuromuscular junction (NMJ) innervation, supporting a role of NMJ dysregulation in chronic functional deficits. Terminal Schwann cells (tSCs) are known to be vital for the maintenance of NMJ structure and function, in addition to guiding repair and regeneration after injury. However, the tSC response to a traumatic muscle injury such as VML is not known. Thus, a study was conducted to investigate the effect of VML on tSC morphological characteristics and neurotrophic signaling proteins in adult male Lewis rats that underwent VML injury to the tibialis anterior muscle using a temporal design with outcome assessments at 3, 7, 14, 21, and 48 days post-injury. The following salient observations were made; first, although there is a loss of innervation over time, the number of tSCs per NMJ increases, significantly so at 48 days post-injury compared to control. The degree of NMJ fragmentation was positively correlated with tSC number after injury. Moreover, neurotrophic factors such as NRG1 and BDNF are elevated after injury through at least 48 days. These results were unanticipated and in contrast to neurodegenerative disease models, in which there is a reduction in tSC number that precedes denervation. However, we found that while there are more tSCs per NMJ after injury, they cover a significantly smaller percent of the post-synaptic endplate area compared to control. These findings support a sustained increase in neurotrophic activity and tSC number after VML, which is a maladaptive response occurring in parallel to other aspects of the VML injury, such as over-accumulation of collagen and aberrant inflammatory signaling.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 AR078903 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: Denervation; Musculoskeletal trauma; Neuromuscular junction; Neurotrophic factors
تواريخ الأحداث: Date Created: 20230504 Date Completed: 20230522 Latest Revision: 20240702
رمز التحديث: 20240702
مُعرف محوري في PubMed: PMC10227691
DOI: 10.1016/j.expneurol.2023.114431
PMID: 37142114
قاعدة البيانات: MEDLINE
الوصف
تدمد:1090-2430
DOI:10.1016/j.expneurol.2023.114431