دورية أكاديمية
Clinical Characteristics Associated with Musculoskeletal Extracutaneous Manifestations in Pediatric and Adult Morphea: A Prospective, Cohort Study.
| العنوان: | Clinical Characteristics Associated with Musculoskeletal Extracutaneous Manifestations in Pediatric and Adult Morphea: A Prospective, Cohort Study. |
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| المؤلفون: | Chen HW; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Walker AM; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Stein AB; Pediatric Dermatology Research Alliance, Portland, Oregon, USA., Chen SL; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Schollaert-Fitch KL; Division of Rheumatology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Torok KS; Division of Rheumatology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Jacobe HT; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: Heidi.Jacobe@UTSouthwestern.edu. |
| المصدر: | The Journal of investigative dermatology [J Invest Dermatol] 2023 Oct; Vol. 143 (10), pp. 1955-1963.e3. Date of Electronic Publication: 2023 May 02. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Scleroderma, Localized* , Autoimmune Diseases*, Humans ; Child ; Adult ; Cohort Studies ; Prospective Studies ; Cross-Sectional Studies |
| مستخلص: | Morphea is an autoimmune condition of the skin associated with functional sequelae resulting from musculoskeletal involvement. Systematic investigation of risk for musculoskeletal involvement is limited, particularly in adults. This knowledge gap impairs patient care because practitioners are unable to risk stratify patients. To address this gap, we determined the frequency, distribution, and type of musculoskeletal (MSK) extracutaneous manifestations affecting joint and bone with overlying morphea lesions using cross-sectional analysis of 1,058 participants enrolled in two prospective cohort registries (Morphea in Children and Adults Cohort [n = 750] and National Registry for Childhood Onset Scleroderma [n = 308]). Additional analysis included the identification of clinical features associated with MSK extracutaneous manifestations. MSK extracutaneous manifestations occurred in 274 of 1,058 participants (26% overall, 32% pediatric, and 21% adults). Children had a limited range of motion of larger joints (i.e., knees/hips/shoulders), whereas the involvement of smaller joints (i.e., toes/temporomandibular joint) was more common in adults. Multivariable logistic regression showed that deep tissue involvement had the strongest association with musculoskeletal features, with a lack of deep tissue involvement having a negative predictive value of 90% for MSK extracutaneous manifestations. Our results underscore the need to evaluate MSK involvement in adult and pediatric patients and the utility of using depth of involvement in addition to anatomic distribution to risk stratify patients. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | R01 AR073516 United States AR NIAMS NIH HHS; R01 AR078560 United States AR NIAMS NIH HHS; TL1 TR001104 United States TR NCATS NIH HHS; UL1 TR000451 United States TR NCATS NIH HHS |
| تواريخ الأحداث: | Date Created: 20230504 Date Completed: 20230925 Latest Revision: 20230927 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jid.2023.04.010 |
| PMID: | 37142185 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1523-1747 |
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| DOI: | 10.1016/j.jid.2023.04.010 |