دورية أكاديمية
أعرض في EDS

A functional SNP in miR-146a and genetic susceptibility to drug-resistant epilepsy.

التفاصيل البيبلوغرافية
العنوان: A functional SNP in miR-146a and genetic susceptibility to drug-resistant epilepsy.
المؤلفون: Abdel-Rasol HA; Clinical and Chemical Pathology Department, Faculty of Medicine, Fayoum University, Fayoum Governorate, Egypt., Abdel Ghaffar H; Pediatric Department, Faculty of Medicine, Fayoum University, Fayoum Governorate, Egypt., Mohamed MS; Clinical pathology department, Fayoum Fever hospital, Fayoum Governorate, Egypt., Jad RW; Medical laboratory technologis, Tiba University, Madina, Saudi Arabia., Abelaleem OO; Biochemistry and molecular biology Department, Faculty of Medicine, Fayoum University, Fayoum Governorate, Egypt., Abdelghaffar NK; Department of Clinical pathology, Faculty of Medicine, Fayoum University, Fayoum Governorate, Egypt.
المصدر: Neurological research [Neurol Res] 2023 Aug; Vol. 45 (8), pp. 765-772. Date of Electronic Publication: 2023 May 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 7905298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-1328 (Electronic) Linking ISSN: 01616412 NLM ISO Abbreviation: Neurol Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2016- : Abingdon : Taylor & Francis
Original Publication: New York, Crane, Russak.
مواضيع طبية MeSH: Drug Resistant Epilepsy*/drug therapy , Drug Resistant Epilepsy*/genetics , Epilepsy*/drug therapy , Epilepsy*/genetics , MicroRNAs*/genetics, Child ; Humans ; Case-Control Studies ; Genetic Predisposition to Disease/genetics ; Genotype ; Polymorphism, Single Nucleotide/genetics
مستخلص: Objectives: The study aimed to assess the relationship between the functional single nucleotide polymorphism (SNP) (rs57095329) of miR-146a, the progression of drug-resistant epilepsy (DRE), and the severity of the disease (seizure frequency) in a group of Egyptian children epilepsy patients.
Subjects and Methods: 110 Egyptian children were recruited and divided into two groups, the epilepsy patients ( n  = 60) and the healthy control children ( n  = 50). The patient's group was equally subdivided into two subgroups: drug-resistant and drug-responsive epilepsy patients. Genomic DNA samples from all participants were screened for the incidence of the rs57095329 SNP of the miR-146a gene by the Real-Time PCR.
Results: There was no statistical significance between epilepsy patients compared to controls    regarding the rs57095329 SNP genotypes and alleles. Contrarily, there was significant difference between the drug-resistant epilepsy and the drug-responsive cases ( P  < 0.05). The genotypes AG ( P  < 0.007, OR: 0.118, 95% CI (0.022-0.636)) and GG ( P  = 0.016, OR: 0.123, 95% CI (0.023-0.769)) were higher among the drug-resistant, while AA was higher among the drug-responsive patients. The alleles A and G were higher among all cases, with a statistically significant difference ( P  = 0.028, OR: 0.441, 95% CI (0.211-0.919)). A significant difference was reported in the dominant model (AA versus AG+GG) ( P  = 0.005, OR: 0.12395% CI (0.025-0.621)).
Conclusion: Therefore, miR-146a might be a potential therapeutic target for epilepsy treatment. The study was limited by the low number of young epileptic patients, the refusal of some parents to participate, and the incomplete medical history of some cases in the study, which forced their exclusion. More studies might be necessary to investigate other effective drugs to overcome the resistance issues induced by miR-146a rs57095329 polymorphisms.
فهرسة مساهمة: Keywords: Drug-resistant epilepsy; Pediatic Epilepsy; miR146a; rs57095329; single nucleotide polymorphism
المشرفين على المادة: 0 (MicroRNAs)
0 (MIRN146 microRNA, human)
تواريخ الأحداث: Date Created: 20230504 Date Completed: 20230731 Latest Revision: 20230731
رمز التحديث: 20231215
DOI: 10.1080/01616412.2023.2203617
PMID: 37142567
قاعدة البيانات: MEDLINE
الوصف
تدمد:1743-1328
DOI:10.1080/01616412.2023.2203617