تقرير
Rare Pseudo-Chediak-Higashi Inclusions in Therapy-Related Acute Myeloid Leukemia with Myelodysplasia-Related Changes.
| العنوان: | Rare Pseudo-Chediak-Higashi Inclusions in Therapy-Related Acute Myeloid Leukemia with Myelodysplasia-Related Changes. |
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| المؤلفون: | Fan Y, Jiang L, Wang N, Liu X, Zhang L |
| المصدر: | Clinical laboratory [Clin Lab] 2023 May 01; Vol. 69 (5). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Clinical Laboratory Publications Country of Publication: Germany NLM ID: 9705611 Publication Model: Print Cited Medium: Internet ISSN: 1433-6510 (Print) Linking ISSN: 14336510 NLM ISO Abbreviation: Clin Lab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2010- : Mainz : Clinical Laboratory Publications Original Publication: Heidelberg : Verlag Klinisches Labor, [1997- |
| مواضيع طبية MeSH: | Leukemia, Myeloid, Acute*/diagnosis , Chediak-Higashi Syndrome*/diagnosis , Chediak-Higashi Syndrome*/pathology , Myelodysplastic Syndromes*/diagnosis , Myelodysplastic Syndromes*/pathology, Humans ; Cytoplasmic Granules/pathology ; Granulocytes ; Inclusion Bodies/pathology |
| مستخلص: | Background: Defined as rare large azurophilic cytoplasmic inclusions, Pseudo-Chediak-Higashi granules mimic those in granulocytes cytoplasm of Chediak-Higashi syndrome. Rare cases of hematopoietic and lymphoid tissues tumors showed Pseudo-Chediak-Higashi inclusions in cytoplasm, some of which presented with unusual morphological characteristics. Methods: Herein, we report the first case, in which rare pseudo-Chediak-Higashi inclusions were observed in therapy-related acute myeloid leukemia with myelodysplasia-related changes (t-AML-MRC). Results: The rare pseudo-Chediak-Higashi inclusions may be positive for Sudan black, and some scholars think that these rare inclusions are a kind of dysgranulopoiesis. Conclusions: The case highlights the significance of an integrated diagnostic work-up, with an interesting effect for morphology. |
| تواريخ الأحداث: | Date Created: 20230505 Date Completed: 20230508 Latest Revision: 20230508 |
| رمز التحديث: | 20230508 |
| DOI: | 10.7754/Clin.Lab.2022.220910 |
| PMID: | 37145084 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1433-6510 |
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| DOI: | 10.7754/Clin.Lab.2022.220910 |