دورية أكاديمية
أعرض في EDS

The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy.

التفاصيل البيبلوغرافية
العنوان: The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy.
المؤلفون: Pavitra E; NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea; 3D Convergence Center, Inha University, Incheon 22212, Republic of Korea., Kancharla J; Department of Bioscience and Biotechnology, Banasthali University, Vanasthali, Rajasthan 304022, India., Gupta VK; NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea., Prasad K; Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495009, Chhattisgarh, India., Sung JY; NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea., Kim J; NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea., Tej MB; Department of Health care informatics, Sacred Heart University, 5151Park Avenue, Fair fields, CT06825, USA., Choi R; 3D Convergence Center, Inha University, Incheon 22212, Republic of Korea; Department of Materials Science and Engineering, Inha University, Incheon 22212, Republic of Korea., Lee JH; 3D Convergence Center, Inha University, Incheon 22212, Republic of Korea; Department of Materials Science and Engineering, Inha University, Incheon 22212, Republic of Korea., Han YK; Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 04620, Republic of Korea., Raju GSR; Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 04620, Republic of Korea. Electronic address: gseetaramaraju7@dongguk.edu., Bhaskar L; Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495009, Chhattisgarh, India. Electronic address: lvksbhaskar@gmail.com., Huh YS; NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea. Electronic address: yunsuk.huh@inha.ac.kr.
المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Jul; Vol. 163, pp. 114822. Date of Electronic Publication: 2023 May 03.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
مواضيع طبية MeSH: NF-kappa B*/metabolism , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics, Female ; Humans ; Signal Transduction ; Oncogenes ; Cell Transformation, Neoplastic ; Cell Line, Tumor
مستخلص: Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
فهرسة مساهمة: Keywords: Angiogenesis; Apoptosis; Breast cancer; Chemoresistance; Metastasis; NF-κB
المشرفين على المادة: 0 (NF-kappa B)
تواريخ الأحداث: Date Created: 20230505 Date Completed: 20230529 Latest Revision: 20230529
رمز التحديث: 20240628
DOI: 10.1016/j.biopha.2023.114822
PMID: 37146418
قاعدة البيانات: MEDLINE
الوصف
تدمد:1950-6007
DOI:10.1016/j.biopha.2023.114822