دورية أكاديمية
أعرض في EDS

Piezo1 opposes age-associated cortical bone loss.

التفاصيل البيبلوغرافية
العنوان: Piezo1 opposes age-associated cortical bone loss.
المؤلفون: Li X; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Zhang C; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Bowman HH; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Stambough JB; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Stronach BM; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Mears SC; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Barnes LC; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Ambrogini E; Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Xiong J; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
المصدر: Aging cell [Aging Cell] 2023 Jun; Vol. 22 (6), pp. e13846. Date of Electronic Publication: 2023 May 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Pub., c2002-
مواضيع طبية MeSH: Bone Diseases, Metabolic* , Mechanotransduction, Cellular*, Aged ; Animals ; Humans ; Mice ; Bone and Bones/metabolism ; Cortical Bone/metabolism ; Ion Channels/genetics ; Ion Channels/metabolism ; Osteoblasts/metabolism ; Osteoclasts/metabolism
مستخلص: As we age, our bones undergo a process of loss, often accompanied by muscle weakness and reduced physical activity. This is exacerbated by decreased responsiveness to mechanical stimulation in aged skeleton, leading to the hypothesis that decreased mechanical stimulation plays an important role in age-related bone loss. Piezo1, a mechanosensitive ion channel, is critical for bone homeostasis and mechanotransduction. Here, we observed a decrease in Piezo1 expression with age in both murine and human cortical bone. Furthermore, loss of Piezo1 in osteoblasts and osteocytes resulted in an increase in age-associated cortical bone loss compared to control mice. The loss of cortical bone was due to an expansion of the endosteal perimeter resulting from increased endocortical resorption. In addition, expression of Tnfrsf11b, encoding anti-osteoclastogenic protein OPG, decreases with Piezo1 in vitro and in vivo in bone cells, suggesting that Piezo1 suppresses osteoclast formation by promoting Tnfrsf11b expression. Our results highlight the importance of Piezo1-mediated mechanical signaling in protecting against age-associated cortical bone loss by inhibiting bone resorption in mice.
(© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: P20 GM125503 United States GM NIGMS NIH HHS; R01 AR076979 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: Piezo1; age-associated bone loss; endocortical bone resorption; mechanical stimulation
المشرفين على المادة: 0 (Ion Channels)
0 (Piezo1 protein, mouse)
0 (PIEZO1 protein, human)
تواريخ الأحداث: Date Created: 20230506 Date Completed: 20230618 Latest Revision: 20230627
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10265162
DOI: 10.1111/acel.13846
PMID: 37147884
قاعدة البيانات: MEDLINE
الوصف
تدمد:1474-9726
DOI:10.1111/acel.13846