دورية أكاديمية
Trogocytosis and cross-dressing in antigen presentation.
| العنوان: | Trogocytosis and cross-dressing in antigen presentation. |
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| المؤلفون: | Schriek P; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia., Villadangos JA; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia. Electronic address: j.villadangos@unimelb.edu.au. |
| المصدر: | Current opinion in immunology [Curr Opin Immunol] 2023 Aug; Vol. 83, pp. 102331. Date of Electronic Publication: 2023 May 04. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8900118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0372 (Electronic) Linking ISSN: 09527915 NLM ISO Abbreviation: Curr Opin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : London : Elsevier Original Publication: Philadelphia, PA, USA : Current Science, c1988- |
| مواضيع طبية MeSH: | Antigen Presentation* , Trogocytosis*, Humans ; Antigen-Presenting Cells ; Histocompatibility Antigens ; Bandages ; Histocompatibility Antigens Class II |
| مستخلص: | Antigen (Ag)-presenting cells capture or synthesize Ags that are processed into peptides bound and displayed on the plasma membrane by major histocompatibility complex (MHC) molecules. Here, we review a mechanism that enables cells to present Ag-loaded MHC molecules that they have not produced themselves, namely trogocytosis. During trogocytosis, a cell acquires fragments from another living cell without, in most cases, affecting the viability of the donor cell. The trogocytic cell can incorporate into its own plasma membrane (becoming cross-dressed) proteins acquired from the donor cell, including intact Ag and MHC molecules. Trogocytosis and cross-dressing expand the immunological functions that immune and nonimmune cells are able to carry out, with both beneficial and deleterious consequences. Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interests. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Histocompatibility Antigens) 0 (Histocompatibility Antigens Class II) |
| تواريخ الأحداث: | Date Created: 20230506 Date Completed: 20230807 Latest Revision: 20230807 |
| رمز التحديث: | 20230807 |
| DOI: | 10.1016/j.coi.2023.102331 |
| PMID: | 37148582 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-0372 |
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| DOI: | 10.1016/j.coi.2023.102331 |