دورية أكاديمية
Allergen exposure boosts peripheral Th9 responses in patients with local allergic rhinitis.
| العنوان: | Allergen exposure boosts peripheral Th9 responses in patients with local allergic rhinitis. |
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| المؤلفون: | Palomares F; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain., Testera-Montes A; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain.; Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain., Aranda CJ; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain., Alba-Linero C; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain.; Ophthalmology Unit, Hospital Clinico Virgen de la Victoria, Malaga, Spain.; School of Medicine, Universidad de Málaga (UMA), Málaga, Spain., Sáenz de Santa María-García R; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain.; Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain., Bentabol-Ramos G; Pulmonology Unit, Hospital Regional Universitario de Malaga, Malaga, Spain., Mayorga C; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain.; Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain., Torres MJ; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain.; Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain.; School of Medicine, Universidad de Málaga (UMA), Málaga, Spain., Rondon C; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain.; Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain., Eguiluz-Gracia I; Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma BIONAND. RETICS Asma, Reacciones Adversas y Alergicas (ARADyAL), and RICORS 'Enfermedades inflamatorias', Málaga, Spain.; Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain. |
| المصدر: | International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2023 Nov; Vol. 13 (11), pp. 2086-2091. Date of Electronic Publication: 2023 May 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published for ARS-AAOA by Wiley-Blackwell Country of Publication: United States NLM ID: 101550261 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-6984 (Electronic) Linking ISSN: 20426976 NLM ISO Abbreviation: Int Forum Allergy Rhinol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken : Published for ARS-AAOA by Wiley-Blackwell |
| مستخلص: | Key Points: Intranasal allergen exposure increases peripheral total Th2 and Th9 cells in patients with local allergic rhinitis (LAR). Peripheral T-cell response seems dominated by Th9 cells in patients with LAR, whereas Th2 responses prevail in patients with allergic rhinitis. Our results identify Th9 cells as potential therapeutic targets for patients with LAR. (© 2023 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.) |
| References: | Testera-Montes A, Palomares F, Jurado-Escobar R, et al. Sequential class switch recombination to IgE and allergen-induced accumulation of IgE(+) plasmablasts occur in the nasal mucosa of local allergic rhinitis patients. Allergy. 2022;77(9):2712-2724. Eguiluz-Gracia I, Bosco A, Dollner R, et al. Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects. J Allergy Clin Immunol. 2016;137(6):1872-1881e12. Auge J, Vent J, Agache I, et al. EAACI position paper on the standardization of nasal allergen challenges. Allergy. 2018;73(8):1597-1608. Gomez E, Fernandez TD, Dona I, et al. Initial immunological changes as predictors for house dust mite immunotherapy response. Clin Exp Allergy. 2015;45(10):1542-1553. Banfield G, Watanabe H, Scadding G, et al. CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses. Allergy. 2010;65(9):1126-1133. Bonvalet M, Moussu H, Wambre E, et al. Allergen-specific CD4+ T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy. Clin Exp Allergy. 2012;42(12):1745-1755. Kallinich T, Beier KC, Wahn U, Stock P, Hamelmann E. T-cell co-stimulatory molecules: their role in allergic immune reactions. Eur Respir J. 2007;29(6):1246-1255. Mikhak Z, Strassner JP, Luster AD. Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J Exp Med. 2013;210(9):1855-1869. Pilette C, Jacobson MR, Ratajczak C, et al. Aberrant dendritic cell function conditions Th2-cell polarization in allergic rhinitis. Allergy. 2013;68(3):312-321. |
| معلومات مُعتمدة: | PI20/01715 Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Science and Competitiveness; PI-0346-2016 Regional Ministry of Health of Andalucia through research projects; PI-0176-2018 Regional Ministry of Health of Andalucia through research projects; P20-00405 Regional Ministry of Education of Andalucia through research project; RH-0028-2021 Francisca Palomares holds a Senior Postdoctoral Program contract; CM20/00160 Almudena Testera-Montes a "Rio Hortega" contract; CD21/00034 Carlos Jose Aranda a "Sara Borrell" contract; CM21/00262 Carmen Alba-Linero a "Río Hortega" contract; JR19/00029 Ibon Eguiluz-Gracia a "Juan Rodes" contract; RC-0004-2021 Cristobalina Mayorga holds a "Nicolas Monardes" contract; RD16/0006/0001 Asma, ReaccionesAdversas y Alérgicas-ARADyAL; RD21/0002/0008 Redes de InvestigacionCooperativaOrientadas al ResultadoenSalud: EnfermedadesInflamatorias |
| فهرسة مساهمة: | Keywords: allergens; allergic rhinitis; biomarker; inhalation allergen challenge; rhinitis; therapeutics |
| تواريخ الأحداث: | Date Created: 20230508 Latest Revision: 20231023 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/alr.23175 |
| PMID: | 37150905 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2042-6984 |
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| DOI: | 10.1002/alr.23175 |