دورية أكاديمية
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Paternal early life stress exerts intergenerational effects on male C57Bl/6J offspring risk-taking behaviors and predator scent-induced c-Fos expression.

التفاصيل البيبلوغرافية
العنوان: Paternal early life stress exerts intergenerational effects on male C57Bl/6J offspring risk-taking behaviors and predator scent-induced c-Fos expression.
المؤلفون: Thivisol UMCC; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.; Department of Anatomy and Physiology, University of Melbourne, VIC 3010, Australia., Ho P; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.; Department of Anatomy and Physiology, University of Melbourne, VIC 3010, Australia., Li B; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.; Department of Anatomy and Physiology, University of Melbourne, VIC 3010, Australia., Trompke M; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia., Hoffmann LB; Department of Anatomy and Physiology, University of Melbourne, VIC 3010, Australia.; The Florey Department of Neuroscience and Mental Health, University of Melbourne, VIC 3010, Australia., Hannan AJ; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.; Department of Anatomy and Physiology, University of Melbourne, VIC 3010, Australia., Pang TY; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.; Department of Anatomy and Physiology, University of Melbourne, VIC 3010, Australia.
المصدر: Neuronal signaling [Neuronal Signal] 2023 Apr 28; Vol. 7 (2), pp. NS20220097. Date of Electronic Publication: 2023 Apr 28 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Portland Press Limited on behalf of the Biochemical Society Country of Publication: England NLM ID: 101721079 Publication Model: eCollection Cited Medium: Internet ISSN: 2059-6553 (Electronic) Linking ISSN: 20596553 NLM ISO Abbreviation: Neuronal Signal Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Portland Press Limited on behalf of the Biochemical Society, [2017]-
مستخلص: Paternal preconceptional health factors, such as exposures to stress, diet and exercise, have been found to significantly influence offspring phenotypes in a range of animal models. Preclinical studies have provided evidence that paternal stress is associated with increased stress responsivity and anxiety-related traits, particularly in male offspring. It was previously reported that a paternal history of maternal separation (MS) led to male offspring (PatMS) displaying reduced cautious behavior during exploration of a novel environment. The neural basis for that absence of behavioral moderation is unclear. Here, we investigated the adaptive behavioral responses of control and PatMS male offspring in the predator odor risk-assessment task (PORT). PatMS mice failed to moderate their behaviors in the presence of a predator odor 2,4,5-trimethylthiazoline (TMT). c-Fos mapping revealed reduced cellular activation in fear-regulating brain regions of PatMS mice, such as in the cingulate cortex, dentate gyrus of the hippocampus and the basolateral amygdala. Expression of the paternally imprinted gene Grb10 (previously identified as a key molecular regulator of risk-taking behavior) was unaltered in PatMS mice. However, other paternal imprinted genes such as Igf2 and PEG3 were differentially expressed in PatMS mice. Overall, our study provides the first evidence of an intergenerational influence of preconceptional paternal stress exposure on offspring brain zunction relevant to risk-taking behavior, which is also independent of Grb10 gene expression.
(© 2023 The Author(s).)
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فهرسة مساهمة: Keywords: Paternal stress; TMT; innate fear; intergenerational inheritance; maternal separation; predator odor
تواريخ الأحداث: Date Created: 20230508 Latest Revision: 20230509
رمز التحديث: 20230509
مُعرف محوري في PubMed: PMC10154287
DOI: 10.1042/NS20220097
PMID: 37152245
قاعدة البيانات: MEDLINE
الوصف
تدمد:2059-6553
DOI:10.1042/NS20220097