دورية أكاديمية
Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β -Thalassemia Patients in Al-Ahsa Region, Saudi Arabia.
العنوان: | Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β -Thalassemia Patients in Al-Ahsa Region, Saudi Arabia. |
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المؤلفون: | Kuriri FA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra, Riyadh Province, Saudi Arabia., Ahmed A; Al-Ahsa Health Cluster, Al-Ahsa, Saudi Arabia., Alanazi F; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences-AlQurayaat, Jouf University, Sakaka, Saudi Arabia., Alhumud F; Al-Ahsa Health Cluster, Al-Ahsa, Saudi Arabia., Ageeli Hakami M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Al-Quwayiyah, Shaqra University, Riyadh, Saudi Arabia., Atiatalla Babiker Ahmed O; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra, Riyadh Province, Saudi Arabia. |
المصدر: | Anemia [Anemia] 2023 Apr 28; Vol. 2023, pp. 3239960. Date of Electronic Publication: 2023 Apr 28 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101536021 Publication Model: eCollection Cited Medium: Print ISSN: 2090-1267 (Print) Linking ISSN: 20901267 NLM ISO Abbreviation: Anemia Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Cairo : Hindawi Pub. Corp. |
مستخلص: | Introduction: The risk of developing transfusion-related complications, especially alloimmunization, is an ongoing concern for transfusion-dependent patients. It is important to determine the rate of alloimmunization and autoimmunization in Al-Ahsa Region, Saudi Arabia, where sickle cell disease (SCD) and thalassemia incidence rates are the highest in Saudi Arabia. Methods: A cross-sectional study was conducted to review the transfusion history of patients with SCD and thalassemia at the King Fahad Hospital (KFH) in Al-Ahsa, Saudi Arabia. 364 transfusion-dependent patients were included in this study. Results: Alloimmunization rates in patients with SCD and thalassemia were 16.7% and 11.97%, respectively, while autoimmunization rates in patients with SCD and thalassemia were 5.3% and 0.7%, respectively. The most frequent alloantibodies among the study participants were against Kell, Rh blood group systems. Conclusion: Blood transfusion-related alloimmunization and autoimmunization compromise the proper management of chronically transfused patients. Ideally, extended matched phenotyping should be implemented to prevent alloimmunization and reduce the risk of developing blood transfusion-related alloantibodies. Competing Interests: The authors declare that they have no conflicts of interest. (Copyright © 2023 Fahd A. Kuriri et al.) |
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تواريخ الأحداث: | Date Created: 20230508 Latest Revision: 20230509 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10162868 |
DOI: | 10.1155/2023/3239960 |
PMID: | 37152479 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2090-1267 |
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DOI: | 10.1155/2023/3239960 |