دورية أكاديمية
أعرض في EDS

Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β -Thalassemia Patients in Al-Ahsa Region, Saudi Arabia.

التفاصيل البيبلوغرافية
العنوان: Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β -Thalassemia Patients in Al-Ahsa Region, Saudi Arabia.
المؤلفون: Kuriri FA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra, Riyadh Province, Saudi Arabia., Ahmed A; Al-Ahsa Health Cluster, Al-Ahsa, Saudi Arabia., Alanazi F; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences-AlQurayaat, Jouf University, Sakaka, Saudi Arabia., Alhumud F; Al-Ahsa Health Cluster, Al-Ahsa, Saudi Arabia., Ageeli Hakami M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Al-Quwayiyah, Shaqra University, Riyadh, Saudi Arabia., Atiatalla Babiker Ahmed O; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra, Riyadh Province, Saudi Arabia.
المصدر: Anemia [Anemia] 2023 Apr 28; Vol. 2023, pp. 3239960. Date of Electronic Publication: 2023 Apr 28 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101536021 Publication Model: eCollection Cited Medium: Print ISSN: 2090-1267 (Print) Linking ISSN: 20901267 NLM ISO Abbreviation: Anemia Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cairo : Hindawi Pub. Corp.
مستخلص: Introduction: The risk of developing transfusion-related complications, especially alloimmunization, is an ongoing concern for transfusion-dependent patients. It is important to determine the rate of alloimmunization and autoimmunization in Al-Ahsa Region, Saudi Arabia, where sickle cell disease (SCD) and thalassemia incidence rates are the highest in Saudi Arabia.
Methods: A cross-sectional study was conducted to review the transfusion history of patients with SCD and thalassemia at the King Fahad Hospital (KFH) in Al-Ahsa, Saudi Arabia. 364 transfusion-dependent patients were included in this study.
Results: Alloimmunization rates in patients with SCD and thalassemia were 16.7% and 11.97%, respectively, while autoimmunization rates in patients with SCD and thalassemia were 5.3% and 0.7%, respectively. The most frequent alloantibodies among the study participants were against Kell, Rh blood group systems.
Conclusion: Blood transfusion-related alloimmunization and autoimmunization compromise the proper management of chronically transfused patients. Ideally, extended matched phenotyping should be implemented to prevent alloimmunization and reduce the risk of developing blood transfusion-related alloantibodies.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Fahd A. Kuriri et al.)
References: Genet Med. 2007 Jun;9(6):372-7. (PMID: 17575503)
Blood. 2019 Apr 25;133(17):1821-1830. (PMID: 30808636)
J Blood Med. 2019 Aug 20;10:283-289. (PMID: 31692490)
Clin Lab. 2021 Jan 1;67(1):. (PMID: 33491438)
Clin Lab. 2021 Feb 1;67(2):. (PMID: 33616335)
Clin Lab. 2021 Oct 1;67(10):. (PMID: 34655200)
Saudi Med J. 2008 Oct;29(10):1480-3. (PMID: 18946577)
Hemoglobin. 2009;33 Suppl 1:S28-36. (PMID: 20001630)
Vox Sang. 2022 Apr;117(4):580-586. (PMID: 34725840)
Mediterr J Hematol Infect Dis. 2017 Feb 15;9(1):e2017013. (PMID: 28293401)
Int J Gen Med. 2022 Apr 15;15:4093-4100. (PMID: 35450032)
East Mediterr Health J. 2007 Sep-Oct;13(5):1181-9. (PMID: 18290412)
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):625-631. (PMID: 27913538)
Lancet. 2013 May 25;381(9880):1845-54. (PMID: 23706801)
Blood. 2008 Oct 1;112(7):2617-26. (PMID: 18809775)
Int J Gen Med. 2021 Dec 03;14:9315-9319. (PMID: 34887679)
Transfus Med Rev. 2014 Jul;28(3):137-44. (PMID: 24928468)
Transfus Apher Sci. 2015 Aug;53(1):52-7. (PMID: 25817267)
Med Clin North Am. 2017 Mar;101(2):431-447. (PMID: 28189180)
Transfusion. 2009 Aug;49(8):1649-54. (PMID: 19453992)
Asian J Transfus Sci. 2014 Jul;8(2):84-8. (PMID: 25161344)
Crit Care Med. 2003 Dec;31(12 Suppl):S678-86. (PMID: 14724466)
تواريخ الأحداث: Date Created: 20230508 Latest Revision: 20230509
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10162868
DOI: 10.1155/2023/3239960
PMID: 37152479
قاعدة البيانات: MEDLINE
الوصف
تدمد:2090-1267
DOI:10.1155/2023/3239960