دورية أكاديمية
أعرض في EDS

Comparison of oxidative stress markers in the saliva, gingival crevicular fluid, and serum samples of pregnant women with gestational diabetes and healthy pregnant women.

التفاصيل البيبلوغرافية
العنوان: Comparison of oxidative stress markers in the saliva, gingival crevicular fluid, and serum samples of pregnant women with gestational diabetes and healthy pregnant women.
المؤلفون: Şimşek OK; Faculty of Dentistry, Periodontology Department, Istanbul University, Istanbul, Turkey., Baser U; Faculty of Dentistry, Periodontology Department, Istanbul University, Istanbul, Turkey., Özgünler Ö; Faculty of Dentistry, Periodontology Department, Istanbul University, Istanbul, Turkey., Demirci O; Perinatology Clinic, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Istanbul, Turkey., Aydin AF; Faculty of Medicine, Department of Medical Biochemistry, Istanbul University, Istanbul, Turkey., Kucukgergin C; Faculty of Medicine, Department of Medical Biochemistry, Istanbul University, Istanbul, Turkey., Yalcin F; Faculty of Dentistry, Periodontology Department, Istanbul University, Istanbul, Turkey.
المصدر: Journal of periodontal research [J Periodontal Res] 2023 Aug; Vol. 58 (4), pp. 745-754. Date of Electronic Publication: 2023 May 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0055107 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0765 (Electronic) Linking ISSN: 00223484 NLM ISO Abbreviation: J Periodontal Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Malden, MA : Wiley-Blackwell
Original Publication: Copenhagen : Munksgaard International Publishers
مواضيع طبية MeSH: Diabetes, Gestational* , Periodontal Diseases*, Humans ; Female ; Pregnancy ; Pregnant Women ; Gingival Crevicular Fluid/chemistry ; Saliva/chemistry ; Oxidative Stress ; Antioxidants/analysis ; Oxidants
مستخلص: Background and Objective: To compare oxidative stress (OS) markers in the saliva, gingival crevicular fluid (GCF), and serum samples of pregnant women with gestational diabetes (GDM) and healthy pregnant women and to investigate the association between periodontal health/diseases and OS and GDM.
Method: Eighty women with GDM and 80 healthy pregnant women were included in the study. Medical and clinical anamnesis was obtained from all the pregnant women included in the study, and their plaque index (PI), gingival index (GI), bleeding on probing (BoP), probing pocket depth (PPD), and clinical attachment level (CAL) measurements were performed. GCF, saliva, and serum samples were collected for the measurements of the local and systemic total antioxidant status (TAS) and total oxidant status (TOS).
Results: Clinical periodontal parameters were found to be significantly higher in the GDM group compared to the control group. The serum and saliva TAS, TOS, and TAS/TOS values were significantly lower in the GDM group than in the control group. In the analysis of the GCF samples, the mean TAS and TAS/TOS values were significantly lower and the TOS value was significantly higher in the GDM group than in the control group. The multivariate reduced model indicated that gravidity, salivary TAS/TOS, and GCF TAS were significant independent variables in the development of GDM (p < .05).
Conclusion: Our results indicated that the OS of serum, saliva, and GCF samples increased in patients with GDM compared to healthy pregnant women. The role of local OS parameters in GDM may be associated with elevated clinical periodontal parameters.
(© 2023 John Wiley & Sons Ltd.)
References: Xiong X, Saunders LD, Wang FL, Demianczuk NN. Gestational diabetes mellitus: prevalence, risk factors, maternal and infant outcomes. Int J Gynecol Obstet. 2001;75(3):221-228. doi:10.1016/s0020-7292(01)00496-9.
American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care. 2017 Jan;40(Suppl 1):S11-S24. doi:10.2337/dc17-S005.
Gestational diabetes mellitus. Diabetes Care. 2003;26(suppl_1):s103-s105. doi:10.2337/diacare.26.2007.s103.
Schneider S, Hoeft B, Freerksen N, et al. Neonatal complications and risk factors among women with gestational diabetes mellitus. Acta Obstet Gynecol Scand. 2010;90(3):231-237. doi:10.1111/j.1600-0412.2010.01040.x.
Ferrara A, Weiss NS, Hedderson MM, et al. Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia, and hyperbilirubinaemia. Diabetologia. 2006;50(2):298-306. doi:10.1007/s00125-006-0517-8.
Ornoy A. Growth and neuro-development of children born to diabetic mothers and to mothers with gestational diabetes. Textbook of Diabetes and Pregnancy. Taylor Francis; 2008:371-378. doi:10.3109/9781439802007.049.
Xiong X, Elkind-Hirsch KE, Vastardis S, Delarosa RL, Pridjian G, Buekens P. Periodontal disease is associated with gestational diabetes mellitus: a case-control study. J Periodontol. 2009;80(11):1742-1749. doi:10.1902/jop.2009.090250.
Bi WG, Emami E, Luo ZC, Santamaria C, Wei SQ. Effect of periodontal treatment in pregnancy on perinatal outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2021 Oct;34(19):3259-3268. doi:10.1080/14767058.2019.1678142.
Armitage GC. Bi-directional relationship between pregnancy and periodontal disease. Periodontol 2000. 2012;61(1):160-176. doi:10.1111/j.1600-0757.2011.00396.x.
Graves DT, Ding Z, Yang Y. The impact of diabetes on periodontal diseases. Periodontol 2000. 2019;82(1):214-224. doi:10.1111/prd.12318.
D'Aiuto F, Orlandi M, Gunsolley JC. Evidence that periodontal treatment improves biomarkers and CVD outcomes. J Clin Periodontol. 2013;40:S85-S105. doi:10.1111/jcpe.12061.
Demmer RT, Trinquart L, Zuk A, et al. The influence of anti-infective periodontal treatment on C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. PLoS One. 2013;8(10):e77441. doi:10.1371/journal.pone.0077441.
Teeuw WJ, Slot DE, Susanto H, et al. Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. J Clin Periodontol. 2013;41(1):70-79. doi:10.1111/jcpe.12171.
Sanz M, Ceriello A, Buysschaert M, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. Diabetes Res Clin Pract. 2018;137:231-241. doi:10.1016/j.diabres.2017.12.001.
Bunpeng N, Boriboonhirunsarn D, Boriboonhirunsarn C, Sawangpanyangkura T, Tansriratanawong K. Association between gestational diabetes mellitus and periodontitis via the effect of reactive oxygen species in peripheral blood cells. J Periodontol. 2022;93(5):758-769. doi:10.1002/JPER.21-0455.
Serefhanoglu K, Taskin A, Turan H, Timurkaynak FE, Arslan H, Erel O. Evaluation of oxidative status in patients with brucellosis. Braz J Infect Dis. 2009;13(4):249-251. doi:10.1590/s1413-86702009000400001.
Chapple IL, Brock GR, Milward MR, Ling N, Matthews JB. Compromised GCF total antioxidant capacity in periodontitis: cause or effect? J Clin Periodontol. 2007;34(2):103-110. doi:10.1111/j.1600-051x.2006.01029.x.
Allen E, Matthews J, O'Connor R, O'Halloran D, Chapple I. Periodontitis and type 2 diabetes: is oxidative stress the mechanistic link? Scott Med J. 2009;54(2):41-47. doi:10.1258/rsmsmj.54.2.41.
Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000. 2007;43(1):160-232. doi:10.1111/j.1600-0757.2006.00178.x.
Allen EM, Matthews JB, O'Halloran DJ, Griffiths HR, Chapple IL. Oxidative and inflammatory status in type 2 diabetes patients with periodontitis. J Clin Periodontol. 2011;38(10):894-901. doi:10.1111/j.1600-051x.2011.01764.x.
Tonetti MS, Van Dyke TE. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the joint EFP/AAPWorkshop on periodontitis and systemic diseases. J Periodontol. 2013;84(4-s):S24-S29. doi:10.1902/jop.2013.1340019.
Bullon P, Roman-Malo L, Marin-Aguilar F, et al. Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement. Pharmacol Res. 2015;91:1-8. doi:10.1016/j.phrs.2014.10.007.
Patil VS. Chronic periodontitis in type 2 diabetes mellitus: oxidative stress as a common factor in periodontal tissue injury. J Clin Diagn Res. 2016;10:BC12v. doi:10.7860/jcdr/2016/17350.7542.
Gogeneni H, Buduneli N, Ceyhan-Öztürk B, et al. Increased infection with key periodontal pathogens during gestational diabetes mellitus. J Clin Periodontol. 2015 Jun;42(6):506-512. doi:10.1111/jcpe.12418.
Akalın FA, Baltacıoğlu E, Alver A, Karabulut E. Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival Crevicular fluid in pregnant women with chronic periodontitis. J Periodontol. 2009;80:457-467. doi:10.1902/jop.2009.080218.
Silness J, Löe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964;22(1):121-135. doi:10.3109/00016356408993968.
Löe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontol Scand. 1963;21(6):533-551. doi:10.3109/00016356309011240.
Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J. 1975;25(4):229-235.
Chapple ILC, Mealey BL, van Dyke TE, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89(Suppl 1):S74-S84. doi:10.1002/JPER.17-0719.
Rüdin HJ, Overdiek HF, Rateitschak KH. Correlation between sulcus fluid rate and clinical and histological inflammation of the marginal gingiva. Helv Odontol Acta. 1970;14(1):21-26.
Shukla GK, Garg A, Bhatia N, et al. Significance of free radicals in chronic tonsillitis. Boll Chim Farm. 2000;139(2):103-105.
Gentric G, Maillet V, Paradis V, et al. Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. J Clin Invest. 2015;125:981-992. doi:10.1172/JCI73957.
Pisoschi AM, Pop A. The role of antioxidants in the chemistry of oxidative stress: a review. Eur J Med Chem. 2015;97:55-74. doi:10.1016/j.ejmech.2015.04.040.
Chapple IL, Brock G, Eftimiadi C, Matthews JB. Glutathione in gingival crevicular fluid and its relation to local antioxidant capacity in periodontal health and disease. Mol Pathol. 2002;55:367-373. doi:10.1136/mp.55.6.367.
Akalin FA, Baltacioglu E, Alver A, Karabulut E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol. 2007;34:558-565. doi:10.1111/j.1600-051X.2007.01091.x.
Canakci V, Yildirim A, Canakci CF, Eltas A, Cicek Y, Canakci H. Total antioxidant capacity and antioxidant enzymes in serum, saliva, and gingival crevicular fluid of preeclamptic women with and without periodontal disease. J Periodontol. 2007;78(8):1602-1611. doi:10.1902/jop.2007.060469.
Canakci CF, Cicek Y, Yildirim A, Sezer U, Canakci V. Increased levels of 8-hydroxydeoxyguanosine and malondialdehyde and its relationship with antioxidant enzymes in saliva of periodontitis patients. Eur J Dent. 2009;3(2):100-106. doi:10.1055/s-0039-1697415.
Pendyala G, Thomas B, Kumari S. The challenge of antioxidants to free radicals in periodontitis. J Indian Soc Periodontol. 2008;12:79-83. doi:10.4103/0972-124X.44100.
Žilinskas J, Kubilius R, Žekonis G, Žekonis J. Total antioxidant capacity of venous blood, blood plasma, and serum of patients with periodontitis, and the effect of Traumeel s on these characteristics. Medicina. 2011;47(4):27. doi:10.3390/medicina47040027.
Sczepanik F, Grossi M, Casati M, et al. Periodontitis is an inflammatory disease of oxidative stress: we should treat it that way. Periodontol 2000. 2020;84(1):45-68. doi:10.1111/prd.12342.
Bagis N, Bostanci HS. The relationship between gestational diabetes mellitus and periodontal health: a case-control study. Int J Exp Dent Sci. 2013;2(2):71-75. doi:10.5005/jp-journals-10029-1044.
Ruiz DR, Romito GA, Dib SA. Periodontal disease in gestational and type 1 diabetes mellitus pregnant women. Oral Dis. 2011;17(5):515-521. doi:10.1111/j.1601-0825.2011.01805.x.
Kumar A, Sharma DS, Verma M, et al. Association between periodontal disease and gestational diabetes mellitus-a prospective cohort study. J Clin Periodontol. 2018;45(8):920-931. doi:10.1111/jcpe.12902.
Abariga SA, Whitcomb BW. Periodontitis and gestational diabetes mellitus: a systematic review and meta-analysis of observational studies. BMC Pregnancy Childbirth. 2016;16(1):344. doi:10.1186/s12884-016-1145-z.
Esteves Lima RP, Cyrino RM, de Carvalho Dutra B, et al. Association between periodontitis and gestational diabetes mellitus: systematic review and meta-analysis. J Periodontol. 2016;87(1):48-57. doi:10.1902/jop.2015.150311.
Esteves Lıma RP, Cota LO, Sılva TA, Cortellı SC, Cortellı JR, Costa FO. Periodontitis and type 2 diabetes among women with previous gestational diabetes: epidemiological and immunological aspects in a follow-up of three years. J Appl Oral Sci. 2017;25(2):130-139. doi:10.1590/1678-77572016-0367.
Xie Y, Xiong X, Elkind-Hirsch KE, et al. Change of periodontal disease status during and after pregnancy. J Periodontol. 2013;84(6):725-731. doi:10.1902/jop.2012.120235.
Sudharshana Murthy KA, Bhandiwada A, Chandan SL, Gowda SL, Sindhusree G. Evaluation of oxidative stress and proinflammatory cytokines in gestational diabetes mellitus and their correlation with pregnancy outcome. Indian J Endocrinol Metab. 2018;22(1):79. doi:10.4103/ijem.ijem_232_16.
Rueangdetnarong H, Sekararithi R, Jaiwongkam T, et al. Comparisons of the oxidative stress biomarkers levels in gestational diabetes mellitus (GDM) and non-GDM among Thai population: cohort study. Endocr Connect. 2018;7(5):681-687. doi:10.1530/ec-18-0093.
Usluoğullari B, Usluogullari CA, Balkan F, Orkmez M. Role of serum levels of Irisin and oxidative stress markers in pregnant women with and without gestational diabetes. Gynecol Endocrinol. 2017;33(5):405-407. doi:10.1080/09513590.2017.1284789.
González-Jaranay M, Téllez L, Roa-López A, Gómez-Moreno G, Moreu G. Periodontal status during pregnancy and postpartum. PLoS One. 2017;12(5):e0178234. doi:10.1371/journal.pone.0178234.
Petitt DJ, Bennett PH, Knowler WC, Baird HR, Aleck KA. Gestational diabetes mellitus and impaired glucose tolerance during pregnancy. Long-term effects on obesity and glucose tolerance in the offspring. Diabetes. 1985;34(Suppl 2):119-122. doi:10.2337/diab.34.2.s119.
معلومات مُعتمدة: TDH-2019-33677 Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi
فهرسة مساهمة: Keywords: gestational diabetes; gingivitis; oxidative stress; periodontal diseases; periodontitis; risk factors; systemic diseases
المشرفين على المادة: 0 (Antioxidants)
0 (Oxidants)
تواريخ الأحداث: Date Created: 20230508 Date Completed: 20230706 Latest Revision: 20230706
رمز التحديث: 20231215
DOI: 10.1111/jre.13132
PMID: 37154237
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0765
DOI:10.1111/jre.13132