دورية أكاديمية
Polyvinyl Alcohol Nanofibers Blends as Drug Delivery System in Tissue Regeneration.
| العنوان: | Polyvinyl Alcohol Nanofibers Blends as Drug Delivery System in Tissue Regeneration. |
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| المؤلفون: | Barros Araújo CB; Pharmaceutical Sciences Postgraduate Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande, 58429-600, Paraíba, Brazil., da Silva Soares IL; Pharmaceutical Sciences Postgraduate Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande, 58429-600, Paraíba, Brazil.; Research Center in Pharmaceutical Sciences, UNIFACISA University Center, Manoel Cardoso Palhano, Campina Grande, 58408-326, Paraíba, Brazil., da Silva Lima DP; Pharmaceutical Sciences Postgraduate Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande, 58429-600, Paraíba, Brazil., Barros RM; Pharmaceutical Sciences Postgraduate Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande, 58429-600, Paraíba, Brazil., de Lima Damasceno BPG; Pharmaceutical Sciences Postgraduate Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande, 58429-600, Paraíba, Brazil., Oshiro-Junior JA; Pharmaceutical Sciences Postgraduate Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande, 58429-600, Paraíba, Brazil.; Research Center in Pharmaceutical Sciences, UNIFACISA University Center, Manoel Cardoso Palhano, Campina Grande, 58408-326, Paraíba, Brazil. |
| المصدر: | Current pharmaceutical design [Curr Pharm Des] 2023 Jun 06; Vol. 29 (15), pp. 1149-1162. |
| نوع المنشور: | Review; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9602487 Publication Model: Print Cited Medium: Internet ISSN: 1873-4286 (Electronic) Linking ISSN: 13816128 NLM ISO Abbreviation: Curr Pharm Des Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, c1995- |
| مواضيع طبية MeSH: | Polyvinyl Alcohol*/chemistry , Nanofibers*, Humans ; Tissue Engineering/methods ; Drug Delivery Systems ; Polymers ; Cell Proliferation ; Tissue Scaffolds |
| مستخلص: | Nanofibers have shown promising clinical results in the process of tissue regeneration since they provide a similar structure to the extracellular matrix of different tissues, high surface-to-volume ratio and porosity, flexibility, and gas permeation, offering topographical features that stimulate cell adhesion and proliferation. Electrospinning is one of the most used techniques for manufacturing nanomaterials due to its simplicity and low cost. In this review, we highlight the use of nanofibers produced with polyvinyl alcohol and polymeric associations (PVA/blends) as a matrix for release capable of modifying the pharmacokinetic profile of different active ingredients in the regeneration of connective, epithelial, muscular, and nervous tissues. Articles were selected by three independent reviewers by analyzing the databases, such as Web of Science, PubMed, Science Direct, and Google Scholar (last 10 years). Descriptors used were "nanofibers", "poly (vinyl alcohol)", "muscle tissue", "connective tissue", "epithelial tissue", and "neural tissue engineering". The guiding question was: How do different compositions of polyvinyl alcohol polymeric nanofibers modify the pharmacokinetics of active ingredients in different tissue regeneration processes? The results demonstrated the versatility of the production of PVA nanofibers by solution blow technique with different actives (lipo/hydrophilic) and with pore sizes varying between 60 and 450 nm depending on the polymers used in the mixture, which influences the drug release that can be controlled for hours or days. The tissue regeneration showed better cellular organization and greater cell proliferation compared to the treatment with the control group, regardless of the tissue analyzed. We highlight that, among all blends, the combinations PVA/PCL and PVA/CS showed good compatibility and slow degradation, indicating their use in prolonged times of biodegradation, thus benefiting tissue regeneration in bone and cartilage connective tissues, acting as a physical barrier that results in guided regeneration, and preventing the invasion of cells from other tissues with increased proliferation rate. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| معلومات مُعتمدة: | Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| فهرسة مساهمة: | Keywords: Nanotechnology; drug delivery; electrospinning; nanomedicine; polymers; scaffolds |
| المشرفين على المادة: | 9002-89-5 (Polyvinyl Alcohol) 0 (Polymers) |
| تواريخ الأحداث: | Date Created: 20230509 Date Completed: 20230612 Latest Revision: 20240408 |
| رمز التحديث: | 20240409 |
| DOI: | 10.2174/1381612829666230508144912 |
| PMID: | 37157221 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-4286 |
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| DOI: | 10.2174/1381612829666230508144912 |