دورية أكاديمية
أعرض في EDS

Physicochemical characterization and cancer cell antiproliferative effect of silver-doped magnesia nanoparticles.

التفاصيل البيبلوغرافية
العنوان: Physicochemical characterization and cancer cell antiproliferative effect of silver-doped magnesia nanoparticles.
المؤلفون: Al-Fahdawi MQ; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Aldoghachi AF; Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, Serdang, 43300, Malaysia.; Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Cheras, 43000, Malaysia., Alhassan FH; Department of Applied Chemistry and Technology, College of Science and Arts, Alkamel University of Jeddah, Jeddah, 21589, Saudi Arabia.; Department of Nanoscience and Nanotechnology, Africa City of Technology, Khartoum Bahari, Khartoum, Sudan., Al-Doghachi FAJ; Department of Chemistry, Faculty of Science, University of Basra, Basra, Iraq., Alshwyeh HA; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.; Basic & Applied Scientific Research Center, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia., Rasedee A; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.; Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Alnasser SM; Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Saudi Arabia., Al-Qubaisi MS; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Ibrahim WN; Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
المصدر: Heliyon [Heliyon] 2023 Apr 17; Vol. 9 (5), pp. e15560. Date of Electronic Publication: 2023 Apr 17 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Silver-doped magnesia nanoparticles (Ag/MgO) were synthesized using the precipitation method and characterized by various techniques such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), Brunner-Emmett-Teller (BET) surface area measurements, and dispersive X-ray spectroscopy (EDX). The morphology of Ag/MgO nanoparticles was determined by transmission and scanning electron microscopy, which revealed cuboidal shaped nanoparticles with sizes ranging from 31 to 68 nm and an average size of 43.5 ± 10.6 nm. The anticancer effects of Ag/MgO nanoparticles were evaluated on human colorectal (HT29) and lung adenocarcinoma (A549) cell lines, and their caspase-3, -8, and -9 activities, as well as Bcl-2, Bax, p53, cytochrome C protein expressions were estimated. Ag/MgO nanoparticles showed selective toxicity towards HT29 and A549 cells while remaining relatively innocuous towards the normal human colorectal, CCD-18Co, and lung, MRC-5 cells. The IC 50 values of Ag/MgO nanoparticles on the HT29 and A549 cells were found to be 90.2 ± 2.6 and 85.0 ± 3.5 μg/mL, respectively. The Ag/MgO nanoparticles upregulated caspase-3 and -9 activities, downregulated Bcl-2, upregulated Bax and p53 protein expressions in the cancer cells. The morphology of the Ag/MgO nanoparticle treated HT29 and A549 cells was typical of apoptosis, with cell detachment, shrinkage, and membrane blebbing. The results suggest that Ag/MgO nanoparticles induce apoptosis in cancer cells and exhibit potential as a promising anticancer agent.
Competing Interests: The authors declare no conflict of interest.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Authors.)
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فهرسة مساهمة: Keywords: A549 cell; Ag/MgO nanoparticles; Antiproliferative; Apoptosis; HT29 cell
تواريخ الأحداث: Date Created: 20230509 Latest Revision: 20230511
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10163622
DOI: 10.1016/j.heliyon.2023.e15560
PMID: 37159701
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2023.e15560